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Surface Activity and Mechanism of Action of Antiarrhythmic Drugs

V. V. Zakusov ; Institute of Pharmacology, Academy of Medical Sciences Moscow, USSR, Institute of Cardiology, Yerevan, Armenia
N. T. Pryanishnikova ; Institute of Pharmacology, Academy of Medical Sciences Moscow, USSR, Institute of Cardiology, Yerevan, Armenia
V. M. Samvelyan ; Institute of Pharmacology, Academy of Medical Sciences Moscow, USSR, Institute of Cardiology, Yerevan, Armenia

Puni tekst: engleski, pdf (5 MB) str. 171-181 preuzimanja: 144* citiraj
APA 6th Edition
Zakusov, V.V., Pryanishnikova, N.T. i Samvelyan, V.M. (1979). Surface Activity and Mechanism of Action of Antiarrhythmic Drugs. Croatica Chemica Acta, 52 (2), 171-181. Preuzeto s https://hrcak.srce.hr/195905
MLA 8th Edition
Zakusov, V. V., et al. "Surface Activity and Mechanism of Action of Antiarrhythmic Drugs." Croatica Chemica Acta, vol. 52, br. 2, 1979, str. 171-181. https://hrcak.srce.hr/195905. Citirano 06.03.2021.
Chicago 17th Edition
Zakusov, V. V., N. T. Pryanishnikova i V. M. Samvelyan. "Surface Activity and Mechanism of Action of Antiarrhythmic Drugs." Croatica Chemica Acta 52, br. 2 (1979): 171-181. https://hrcak.srce.hr/195905
Harvard
Zakusov, V.V., Pryanishnikova, N.T., i Samvelyan, V.M. (1979). 'Surface Activity and Mechanism of Action of Antiarrhythmic Drugs', Croatica Chemica Acta, 52(2), str. 171-181. Preuzeto s: https://hrcak.srce.hr/195905 (Datum pristupa: 06.03.2021.)
Vancouver
Zakusov VV, Pryanishnikova NT, Samvelyan VM. Surface Activity and Mechanism of Action of Antiarrhythmic Drugs. Croatica Chemica Acta [Internet]. 1979 [pristupljeno 06.03.2021.];52(2):171-181. Dostupno na: https://hrcak.srce.hr/195905
IEEE
V.V. Zakusov, N.T. Pryanishnikova i V.M. Samvelyan, "Surface Activity and Mechanism of Action of Antiarrhythmic Drugs", Croatica Chemica Acta, vol.52, br. 2, str. 171-181, 1979. [Online]. Dostupno na: https://hrcak.srce.hr/195905. [Citirano: 06.03.2021.]

Sažetak
Surface active substances are widely used in medicine, among
them the drugs capable of adsorption in efficient concentrations at
various interface points. The relationship between the pharmacological
action of a ntiarrhythmic drugs and their surface activity and
influence on the lipid-containing interfaces (bimolecular layers of
phosphatidylcholine) have been studied. It has been revealed that
diphisopronyle (diethylaminopropyl ether a-isopropyloxydiphenylacetic
acid, hydrochloride), fubromegane (1-methyl-3-diethylaminopropyl
ether 5-bromofurane-2-carboxylic acid, iodomethylate), methamicile
(~-diethylaminopropyl ether benzyl acid, hydrochloride),
propranolole (l-isopropylamino-3 (oxynaphtyl-1)--propanol-2, hydrochloride),
chinidine (chinidine sulphate), novocainamide (~-diethylaminoethyl-
amid p-aminobenzoic acid, hydrochloride), novocaine
(~ -diethylaminoethyl ether p-aminobenzoic acid, hydrochloride), xylocaine
(N,N-diethylamino-2,6-dimethylacethanilide, hydrochloride),
trimecaine (N,N-diethylamino-2,4,6-trimethylacethanilide, hydrochloride)
possess surface activity. Parallelism between the physiological
action and interfacial activity of antiarrhythmic drugs has
been established. Antiarrhythmics increase the electric conductance
of lecithine bilayers. There exists a symbate dependence between
the effect of drugs on the permeability of a bimolecular lecithin
membrane and . their pharmacological activity. These results are
essential a) for understanding the mode of action of antiarrhythmic
agents and b) discovering new drugs which possess the required
properties.

Hrčak ID: 195905

URI
https://hrcak.srce.hr/195905

Posjeta: 203 *