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Acta Pharmaceutica, Vol. 68 No. 3, 2018.

Kratko priopćenje
https://doi.org/10.2478/acph-2018-0027

Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats

BLANDINA BERNAL-MORALES   ORCID icon orcid.org/0000-0001-5370-4157 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
GABRIEL GUILLÉN-RUIZ   ORCID icon orcid.org/0000-0003-4428-4706 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
JONATHAN CUETO-ESCOBEDO   ORCID icon orcid.org/0000-0003-1465-012X ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
JUAN FRANCISCO RODRÍGUEZ-LANDA   ORCID icon orcid.org/0000-0001-5837-103X ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México
CARLOS M. CONTRERAS   ORCID icon orcid.org/0000-0002-8471-8989 ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, México; Unidad Periférica Xalapa, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Neuroetología, Universidad Vera

Puni tekst: engleski, pdf (387 KB) str. 381-388 preuzimanja: 89* citiraj
APA 6th Edition
BERNAL-MORALES, B., GUILLÉN-RUIZ, G., CUETO-ESCOBEDO, J., RODRÍGUEZ-LANDA, J.F. i CONTRERAS, C.M. (2018). Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats. Acta Pharmaceutica, 68 (3), 381-388. https://doi.org/10.2478/acph-2018-0027
MLA 8th Edition
BERNAL-MORALES, BLANDINA, et al. "Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats." Acta Pharmaceutica, vol. 68, br. 3, 2018, str. 381-388. https://doi.org/10.2478/acph-2018-0027. Citirano 19.05.2019.
Chicago 17th Edition
BERNAL-MORALES, BLANDINA, GABRIEL GUILLÉN-RUIZ, JONATHAN CUETO-ESCOBEDO, JUAN FRANCISCO RODRÍGUEZ-LANDA i CARLOS M. CONTRERAS. "Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats." Acta Pharmaceutica 68, br. 3 (2018): 381-388. https://doi.org/10.2478/acph-2018-0027
Harvard
BERNAL-MORALES, B., et al. (2018). 'Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats', Acta Pharmaceutica, 68(3), str. 381-388. doi: https://doi.org/10.2478/acph-2018-0027
Vancouver
BERNAL-MORALES B, GUILLÉN-RUIZ G, CUETO-ESCOBEDO J, RODRÍGUEZ-LANDA JF, CONTRERAS CM. Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats. Acta Pharm. [Internet]. 2018 [pristupljeno 19.05.2019.];68(3):381-388. doi: https://doi.org/10.2478/acph-2018-0027
IEEE
B. BERNAL-MORALES, G. GUILLÉN-RUIZ, J. CUETO-ESCOBEDO, J.F. RODRÍGUEZ-LANDA i C.M. CONTRERAS, "Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats", Acta Pharmaceutica, vol.68, br. 3, str. 381-388, 2018. [Online]. doi: https://doi.org/10.2478/acph-2018-0027

Sažetak
The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited an increase in anxiety-like behavior in the elevated plus maze (EPM) and open field test (OFT) compared to the non-stressed group. Diazepam (1 h before the tests) reduced anxiety-like behavior in rats forced to swim compared to the vehicle stressed group. The dose-response curve for diazepam indicated that the 0.5 mg kg–1 dose (1 h before the EPM and OFT) was the minimum effective dose in reducing anxiety-like behavior without altering locomotor activity in weaning rats. These results indicate that weaning rats can develop anxiety-like behavior after a brief, single session of stress, and that rats at this age are seemingly more sensitive to diazepam than adult rats, which may be taken into account for clinical applications.

Ključne riječi
anxiety; diazepam; weaning rats; elevated plus maze; forced swim; open field test

Hrčak ID: 196040

URI
https://hrcak.srce.hr/196040

Posjeta: 154 *