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Review article
https://doi.org/10.5599/admet.532

Block relevance (BR) analysis and polarity descriptors in property-based drug design

Giuseppe Ermondi ; Molecular Biotechnology and Health Sciences Dept., Università degli Studi di Torino, via Quarello 15, 10135 Torino, Italy
Giulia Caron ; Molecular Biotechnology and Health Sciences Dept., Università degli Studi di Torino, via Quarello 15, 10135 Torino, Italy

Fulltext: english, pdf (1 MB) pages 215-224 downloads: 224* cite
APA 6th Edition
Ermondi, G. & Caron, G. (2018). Block relevance (BR) analysis and polarity descriptors in property-based drug design. ADMET and DMPK, 6 (3), 215-224. https://doi.org/10.5599/admet.532
MLA 8th Edition
Ermondi, Giuseppe and Giulia Caron. "Block relevance (BR) analysis and polarity descriptors in property-based drug design." ADMET and DMPK, vol. 6, no. 3, 2018, pp. 215-224. https://doi.org/10.5599/admet.532. Accessed 28 Mar. 2020.
Chicago 17th Edition
Ermondi, Giuseppe and Giulia Caron. "Block relevance (BR) analysis and polarity descriptors in property-based drug design." ADMET and DMPK 6, no. 3 (2018): 215-224. https://doi.org/10.5599/admet.532
Harvard
Ermondi, G., and Caron, G. (2018). 'Block relevance (BR) analysis and polarity descriptors in property-based drug design', ADMET and DMPK, 6(3), pp. 215-224. https://doi.org/10.5599/admet.532
Vancouver
Ermondi G, Caron G. Block relevance (BR) analysis and polarity descriptors in property-based drug design. ADMET and DMPK [Internet]. 2018 [cited 2020 March 28];6(3):215-224. https://doi.org/10.5599/admet.532
IEEE
G. Ermondi and G. Caron, "Block relevance (BR) analysis and polarity descriptors in property-based drug design", ADMET and DMPK, vol.6, no. 3, pp. 215-224, 2018. [Online]. https://doi.org/10.5599/admet.532

Abstracts
Block Relevance (BR) analysis is a tool to interpret QSPR/PLS models which can provide the information content of any physicochemical determinant used in property-based drug discovery; its application for the characterization of experimental polarity descriptors is discussed.

Keywords
ADME; hydrogen bonding; IAM; QSPR; PLS; PSA; VIP

Hrčak ID: 205903

URI
https://hrcak.srce.hr/205903

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