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Original scientific paper
https://doi.org/10.5599/admet.647

Bioenhancing effects of naringin on atorvastatin

Venkatesh Sama ; G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
Balaraju Pagilla ; G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
Rajeswari Chiluka ; G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
Ravi Alvala ; G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
Ravi Kumar Pola ; G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
Ramesh Mullangi ; JubilantBiosys, Industrial Suburb, Yeshwanthpur, Bangalore-566022, India

Fulltext: english, pdf (494 KB) pages 174-182 downloads: 115* cite
APA 6th Edition
Sama, V., Pagilla, B., Chiluka, R., Alvala, R., Pola, R.K. & Mullangi, R. (2019). Bioenhancing effects of naringin on atorvastatin. ADMET and DMPK, 7 (3), 174-182. https://doi.org/10.5599/admet.647
MLA 8th Edition
Sama, Venkatesh, et al. "Bioenhancing effects of naringin on atorvastatin." ADMET and DMPK, vol. 7, no. 3, 2019, pp. 174-182. https://doi.org/10.5599/admet.647. Accessed 9 Aug. 2020.
Chicago 17th Edition
Sama, Venkatesh, Balaraju Pagilla, Rajeswari Chiluka, Ravi Alvala, Ravi Kumar Pola and Ramesh Mullangi. "Bioenhancing effects of naringin on atorvastatin." ADMET and DMPK 7, no. 3 (2019): 174-182. https://doi.org/10.5599/admet.647
Harvard
Sama, V., et al. (2019). 'Bioenhancing effects of naringin on atorvastatin', ADMET and DMPK, 7(3), pp. 174-182. https://doi.org/10.5599/admet.647
Vancouver
Sama V, Pagilla B, Chiluka R, Alvala R, Pola RK, Mullangi R. Bioenhancing effects of naringin on atorvastatin. ADMET and DMPK [Internet]. 2019 [cited 2020 August 09];7(3):174-182. https://doi.org/10.5599/admet.647
IEEE
V. Sama, B. Pagilla, R. Chiluka, R. Alvala, R.K. Pola and R. Mullangi, "Bioenhancing effects of naringin on atorvastatin", ADMET and DMPK, vol.7, no. 3, pp. 174-182, 2019. [Online]. https://doi.org/10.5599/admet.647

Abstracts
Naringin (CAS no: 10236-47-2) is a flavonone glycoside obtained from Citrus paradisi (grapefruit), a natural bioenhancer and reported to enhance the bioavailability of drugs by inhibiting cytochrome P450 and P-glycoprotein (P-gp). The aim of the present study was to investigate the effect of naringin on antihyperlipidemic properties of atorvastatin (AST) in tyloxapol induced hyperlipidemic rats and the effects were supported with measurement of plasma concentrations of AST by HPLC method. Animals received AST along with naringin (15 and 30 mg/kg) shown higher percent reduction in both cholesterol and triglycerides levels, when compared to animals received AST alone at dose of 25 and 50 mg/kg and it was found that the higher percent reduction in cholesterol and triglycerides was proportional to increase in plasma concentration of AST. From the results it is evident that the co-administration of naringin along with AST increased the plasma concentration of AST. The findings of the present study confirmed that naringin could be used as bioenhancer. The co-administration of AST and the diet with naringin (grapefruit) to the patients may potentiate the therapeutic efficacy of AST.

Keywords
Naringin; Bioenhancer; Atorvastatin; Tyloxapol; Plasma concentrations; RP-HPLC

Hrčak ID: 224001

URI
https://hrcak.srce.hr/224001

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