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https://doi.org/10.2478/aiht-2020-71-3344

Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form

Semiha Erisen ; Yildiz Technical University, Faculty of Science and Letters Molecular Biology and Genetics Department, Esenler- Istanbul, Turkey
Tülin Arasoğlu ; Yildiz Technical University, Faculty of Science and Letters Molecular Biology and Genetics Department, Esenler- Istanbul, Turkey
Banu Mansuroglu ; Yildiz Technical University, Faculty of Science and Letters Molecular Biology and Genetics Department, Esenler- Istanbul, Turkey
İsmail Kocacaliskan ; Yildiz Technical University, Faculty of Science and Letters Molecular Biology and Genetics Department, Esenler- Istanbul, Turkey
Serap Derman ; Yildiz Technical University, Faculty of Chemical and Metallurgical Engineering, Department of Bioengineering, Istanbul, Turkey

Puni tekst: engleski, pdf (1 MB) str. 69-77 preuzimanja: 147* citiraj
APA 6th Edition
Erisen, S., Arasoğlu, T., Mansuroglu, B., Kocacaliskan, İ. i Derman, S. (2020). Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form. Arhiv za higijenu rada i toksikologiju, 71 (1), 69-77. https://doi.org/10.2478/aiht-2020-71-3344
MLA 8th Edition
Erisen, Semiha, et al. "Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form." Arhiv za higijenu rada i toksikologiju, vol. 71, br. 1, 2020, str. 69-77. https://doi.org/10.2478/aiht-2020-71-3344. Citirano 09.03.2021.
Chicago 17th Edition
Erisen, Semiha, Tülin Arasoğlu, Banu Mansuroglu, İsmail Kocacaliskan i Serap Derman. "Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form." Arhiv za higijenu rada i toksikologiju 71, br. 1 (2020): 69-77. https://doi.org/10.2478/aiht-2020-71-3344
Harvard
Erisen, S., et al. (2020). 'Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form', Arhiv za higijenu rada i toksikologiju, 71(1), str. 69-77. https://doi.org/10.2478/aiht-2020-71-3344
Vancouver
Erisen S, Arasoğlu T, Mansuroglu B, Kocacaliskan İ, Derman S. Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form. Arh Hig Rada Toksikol. [Internet]. 2020 [pristupljeno 09.03.2021.];71(1):69-77. https://doi.org/10.2478/aiht-2020-71-3344
IEEE
S. Erisen, T. Arasoğlu, B. Mansuroglu, İ. Kocacaliskan i S. Derman, "Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form", Arhiv za higijenu rada i toksikologiju, vol.71, br. 1, str. 69-77, 2020. [Online]. https://doi.org/10.2478/aiht-2020-71-3344

Sažetak
Despite its evidenced beneficial herbicidal, antibacterial, antiviral, antifungal, and antioxidant effects, the application of juglone (5-hydroxy-1,4,-naphthoquinone) is limited due to its low water solubility and allelopathic and toxic effects. In recent years, research has aimed to overcome these limitations by increasing its solubility and controlling its release through nanoparticular systems. This is the first study to have synthesised and characterised juglone-loaded polymeric nanoparticles and compared them with free juglone for cytotoxicity in mouse (L929 fibroblasts) and alfalfa cells and for mutagenic potential in Salmonella typhimurium TA98/100. Mouse and plant cells treated with free and nano-encapsulated juglone showed a decrease in cell viability in a dose and time-dependent manner, but this effect was significantly lower with the nanoencapsulated form at lower doses. In the TA98 strain with S9, nano-encapsulated juglone did not exhibit mutagenic effects, unlike the free form. Since all results show that juglone encapsulation with polymeric nanoparticles reduced the toxic and mutagenic effects, it has a promising potential to be applied in medicine, food safety, and agriculture.

Ključne riječi
alfalfa; L929 fibroblasts; nanoparticle; PLGA; S. typhimurium

Hrčak ID: 236214

URI
https://hrcak.srce.hr/236214

[hrvatski]

Posjeta: 300 *