Abscopal effect of radiotherapy: an old concept in a new era
Martina Mikulandra
; Division of Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Iva Andrašek
; Division of Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Lidija Beketić-Orešković
; Division of Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Clinical Oncology, School of Medicine University of Zagreb, Zagreb, Croatia
APA 6th Edition Mikulandra, M., Andrašek, I. i Beketić-Orešković, L. (2020). Abscopal effect of radiotherapy: an old concept in a new era. Libri Oncologici, 48 (1), 27-34. https://doi.org/10.20471/LO.2020.48.01.05
MLA 8th Edition Mikulandra, Martina, et al. "Abscopal effect of radiotherapy: an old concept in a new era." Libri Oncologici, vol. 48, br. 1, 2020, str. 27-34. https://doi.org/10.20471/LO.2020.48.01.05. Citirano 24.01.2021.
Chicago 17th Edition Mikulandra, Martina, Iva Andrašek i Lidija Beketić-Orešković. "Abscopal effect of radiotherapy: an old concept in a new era." Libri Oncologici 48, br. 1 (2020): 27-34. https://doi.org/10.20471/LO.2020.48.01.05
Harvard Mikulandra, M., Andrašek, I., i Beketić-Orešković, L. (2020). 'Abscopal effect of radiotherapy: an old concept in a new era', Libri Oncologici, 48(1), str. 27-34. https://doi.org/10.20471/LO.2020.48.01.05
Vancouver Mikulandra M, Andrašek I, Beketić-Orešković L. Abscopal effect of radiotherapy: an old concept in a new era. Libri Oncologici [Internet]. 2020 [pristupljeno 24.01.2021.];48(1):27-34. https://doi.org/10.20471/LO.2020.48.01.05
IEEE M. Mikulandra, I. Andrašek i L. Beketić-Orešković, "Abscopal effect of radiotherapy: an old concept in a new era", Libri Oncologici, vol.48, br. 1, str. 27-34, 2020. [Online]. https://doi.org/10.20471/LO.2020.48.01.05
Sažetak The abscopal effect is a phenomenon that describes the systemic antitumor response that can occur as a result of a localized radiotherapy. Although sporadic cases of abscopal effect have been reported since 1960’s, the number of reported cases are significantly increasing in the immunotherapy era. Immunotherapy seems to enhance the immunogenic effects of radiotherapy, thus increasing systemic antitumor response. Although combination of radiotherapy and immunotherapy is a promising strategy in the treatment of metastatic cancers, many questions regarding the optimal treatment remain unanswered. Increasing number of ongoing studies will hopefully provide answers to these questions, enabling the utilization of this strategy in systemic anticancer treatment.