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https://doi.org/10.2478/aiht-2020-71-3378

ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients

Davorka Sutlović   ORCID icon orcid.org/0000-0002-9899-5119 ; University of Split Department for Health Studies, Split, Croatia 2 University of Split School of Medicine, Department of Toxicology and Pharmacogenetics, Split, Croatia
Željko Ključević ; Public Health Institute of the Split-Dalmatia County, Department of Mental Health, Prevention and Outpatient Addiction Treatment, Split, Croatia
Sendi Kuret ; University of Split Department for Health Studies, Split, Croatia, 4 University Hospital Centre Split, Department of Pathology and Forensic Medicine, Split, Croatia

Puni tekst: engleski, pdf (375 KB) str. 353-358 preuzimanja: 249* citiraj
APA 6th Edition
Sutlović, D., Ključević, Ž. i Kuret, S. (2020). ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients. Arhiv za higijenu rada i toksikologiju, 71 (4), 353-358. https://doi.org/10.2478/aiht-2020-71-3378
MLA 8th Edition
Sutlović, Davorka, et al. "ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients." Arhiv za higijenu rada i toksikologiju, vol. 71, br. 4, 2020, str. 353-358. https://doi.org/10.2478/aiht-2020-71-3378. Citirano 02.08.2021.
Chicago 17th Edition
Sutlović, Davorka, Željko Ključević i Sendi Kuret. "ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients." Arhiv za higijenu rada i toksikologiju 71, br. 4 (2020): 353-358. https://doi.org/10.2478/aiht-2020-71-3378
Harvard
Sutlović, D., Ključević, Ž., i Kuret, S. (2020). 'ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients', Arhiv za higijenu rada i toksikologiju, 71(4), str. 353-358. https://doi.org/10.2478/aiht-2020-71-3378
Vancouver
Sutlović D, Ključević Ž, Kuret S. ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients. Arh Hig Rada Toksikol. [Internet]. 2020 [pristupljeno 02.08.2021.];71(4):353-358. https://doi.org/10.2478/aiht-2020-71-3378
IEEE
D. Sutlović, Ž. Ključević i S. Kuret, "ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients", Arhiv za higijenu rada i toksikologiju, vol.71, br. 4, str. 353-358, 2020. [Online]. https://doi.org/10.2478/aiht-2020-71-3378
Puni tekst: hrvatski, pdf (375 KB) str. 358-358 preuzimanja: 50* citiraj
APA 6th Edition
Sutlović, D., Ključević, Ž. i Kuret, S. (2020). Polimorfizmi gena ABCB1, CYP2B6 i CYP3A4 ne utječu na metadonsku terapiju održavanja u bolesnika s HCV-om. Arhiv za higijenu rada i toksikologiju, 71 (4), 358-358. https://doi.org/10.2478/aiht-2020-71-3378
MLA 8th Edition
Sutlović, Davorka, et al. "Polimorfizmi gena ABCB1, CYP2B6 i CYP3A4 ne utječu na metadonsku terapiju održavanja u bolesnika s HCV-om." Arhiv za higijenu rada i toksikologiju, vol. 71, br. 4, 2020, str. 358-358. https://doi.org/10.2478/aiht-2020-71-3378. Citirano 02.08.2021.
Chicago 17th Edition
Sutlović, Davorka, Željko Ključević i Sendi Kuret. "Polimorfizmi gena ABCB1, CYP2B6 i CYP3A4 ne utječu na metadonsku terapiju održavanja u bolesnika s HCV-om." Arhiv za higijenu rada i toksikologiju 71, br. 4 (2020): 358-358. https://doi.org/10.2478/aiht-2020-71-3378
Harvard
Sutlović, D., Ključević, Ž., i Kuret, S. (2020). 'Polimorfizmi gena ABCB1, CYP2B6 i CYP3A4 ne utječu na metadonsku terapiju održavanja u bolesnika s HCV-om', Arhiv za higijenu rada i toksikologiju, 71(4), str. 358-358. https://doi.org/10.2478/aiht-2020-71-3378
Vancouver
Sutlović D, Ključević Ž, Kuret S. Polimorfizmi gena ABCB1, CYP2B6 i CYP3A4 ne utječu na metadonsku terapiju održavanja u bolesnika s HCV-om. Arh Hig Rada Toksikol. [Internet]. 2020 [pristupljeno 02.08.2021.];71(4):358-358. https://doi.org/10.2478/aiht-2020-71-3378
IEEE
D. Sutlović, Ž. Ključević i S. Kuret, "Polimorfizmi gena ABCB1, CYP2B6 i CYP3A4 ne utječu na metadonsku terapiju održavanja u bolesnika s HCV-om", Arhiv za higijenu rada i toksikologiju, vol.71, br. 4, str. 358-358, 2020. [Online]. https://doi.org/10.2478/aiht-2020-71-3378

Sažetak
The aim of this study was to determine the influence of ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms on methadone metabolism in patients with hepatitis C virus (HCV) undergoing methadone maintenance treatment (MMT).The study included 35 participants undergoing MMT, who were divided in three groups: HCV-positive (N=12), HCVnegative (N=16), and HCV clinical remission (CR) (N=7). The concentrations of methadone and its main metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) were determined with gas chromatography-mass spectrometry. The patients were genotyped for ABCB1 rs1045642, CYP2B6 rs3745274, CYP3A4 rs2242480, and CYP3A4 rs2740574 polymorphisms. Differences between single nucleotide polymorphism (SNP) genotypes and methadone-to-EDDP ratio were analysed with one-way ANOVA, which showed no significant difference between the genes (p=0.3772 for ABCB1 rs1045642, p=0.6909 for CYP2B6 rs3745274, and p=0.6533 for CYP3A4 rs2242480). None of the four analysed SNP genotypes correlated with methadone-to-EDDP concentration ratio. A major influence on it in hepatitis C-positive patients turned out to be the stage of liver damage.

Ključne riječi
EDDP; genotyping; hepatitis C; liver damage; SNP

Hrčak ID: 248053

URI
https://hrcak.srce.hr/248053

[hrvatski]

Posjeta: 552 *