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Acta Pharmaceutica, Vol. 58 No. 3, 2008.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-008-0014-3

Liposomi rivastigmina za isporuku u mozak intranazalnim putem

KARTHIK ARUMUGAM ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
GANESA SUNDARARAJAN SUBRAMANIAN ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
SURULIVEL RAJAN MALLAYASAMY ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
RANJITH KUMAR AVERINENI ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
MEKA SREENIVASA REDDY ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
NAYANABHIRAMA UDUPA ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India

Puni tekst: engleski, pdf (99 KB) str. 287-297 preuzimanja: 1.285* citiraj
APA 6th Edition
ARUMUGAM, K., SUNDARARAJAN SUBRAMANIAN, G., RAJAN MALLAYASAMY, S., KUMAR AVERINENI, R., SREENIVASA REDDY, M. i UDUPA, N. (2008). A study of rivastigmine liposomes for delivery into the brain through the intranasal route. Acta Pharmaceutica, 58 (3), 287-297. https://doi.org/10.2478/v10007-008-0014-3
MLA 8th Edition
ARUMUGAM, KARTHIK, et al. "A study of rivastigmine liposomes for delivery into the brain through the intranasal route." Acta Pharmaceutica, vol. 58, br. 3, 2008, str. 287-297. https://doi.org/10.2478/v10007-008-0014-3. Citirano 20.02.2019.
Chicago 17th Edition
ARUMUGAM, KARTHIK, GANESA SUNDARARAJAN SUBRAMANIAN, SURULIVEL RAJAN MALLAYASAMY, RANJITH KUMAR AVERINENI, MEKA SREENIVASA REDDY i NAYANABHIRAMA UDUPA. "A study of rivastigmine liposomes for delivery into the brain through the intranasal route." Acta Pharmaceutica 58, br. 3 (2008): 287-297. https://doi.org/10.2478/v10007-008-0014-3
Harvard
ARUMUGAM, K., et al. (2008). 'A study of rivastigmine liposomes for delivery into the brain through the intranasal route', Acta Pharmaceutica, 58(3), str. 287-297. doi: https://doi.org/10.2478/v10007-008-0014-3
Vancouver
ARUMUGAM K, SUNDARARAJAN SUBRAMANIAN G, RAJAN MALLAYASAMY S, KUMAR AVERINENI R, SREENIVASA REDDY M, UDUPA N. A study of rivastigmine liposomes for delivery into the brain through the intranasal route. Acta Pharm. [Internet]. 2008 [pristupljeno 20.02.2019.];58(3):287-297. doi: https://doi.org/10.2478/v10007-008-0014-3
IEEE
K. ARUMUGAM, G. SUNDARARAJAN SUBRAMANIAN, S. RAJAN MALLAYASAMY, R. KUMAR AVERINENI, M. SREENIVASA REDDY i N. UDUPA, "A study of rivastigmine liposomes for delivery into the brain through the intranasal route", Acta Pharmaceutica, vol.58, br. 3, str. 287-297, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0014-3

Sažetak
Glavni cilj rada je razvoj liposoma za intranazalnu primjenu za isporuku lijeka u mozak. U tu svrhu izabran je rivastigmin kao modelni lijek koji se upotrebljava u terapiji Alzheimerove bolesti. Liposomi su pripravljeni metodom hidratacije lipidnog sloja koristeći kolesterol i lecitin iz soje kao lipidne komponente. Praćena je koncentracija rivastigmina u mozgu i plazmi nakon intranazalne i peroralne primjene liposoma i slobodnog lijeka. S intranazalnim liposomima rivastigmina postignuta je značajno veća koncentracija lijeka u mozgu. Osim toga intranazalni liposomi imaju dulje vrijeme poluživota u mozgu. Intranazalna primjena liposoma rivastigmina mogla bi predstavljati novi pristup terapiji Alzheimerove bolesti.

Ključne riječi
rivastigmin; liposomi; intranazalna primjena; isporuka lijeka u mozak; farmakokinetika

Hrčak ID: 25019

URI
https://hrcak.srce.hr/25019

[engleski]

Posjeta: 1.750 *