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Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis

Larisa Prpić Massari
Marija Kaštelan
Franjo Gruber

Puni tekst: engleski, pdf (83 KB) str. 83-85 preuzimanja: 334* citiraj
APA 6th Edition
Prpić Massari, L., Kaštelan, M. i Gruber, F. (2007). Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis. Collegium antropologicum, 31 - Supplement 1 (1), 83-85. Preuzeto s https://hrcak.srce.hr/27430
MLA 8th Edition
Prpić Massari, Larisa, et al. "Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis." Collegium antropologicum, vol. 31 - Supplement 1, br. 1, 2007, str. 83-85. https://hrcak.srce.hr/27430. Citirano 15.10.2019.
Chicago 17th Edition
Prpić Massari, Larisa, Marija Kaštelan i Franjo Gruber. "Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis." Collegium antropologicum 31 - Supplement 1, br. 1 (2007): 83-85. https://hrcak.srce.hr/27430
Harvard
Prpić Massari, L., Kaštelan, M., i Gruber, F. (2007). 'Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis', Collegium antropologicum, 31 - Supplement 1(1), str. 83-85. Preuzeto s: https://hrcak.srce.hr/27430 (Datum pristupa: 15.10.2019.)
Vancouver
Prpić Massari L, Kaštelan M, Gruber F. Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis. Collegium antropologicum [Internet]. 2007 [pristupljeno 15.10.2019.];31 - Supplement 1(1):83-85. Dostupno na: https://hrcak.srce.hr/27430
IEEE
L. Prpić Massari, M. Kaštelan i F. Gruber, "Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis", Collegium antropologicum, vol.31 - Supplement 1, br. 1, str. 83-85, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/27430. [Citirano: 15.10.2019.]

Sažetak
Basal cell carcinoma and squamous cell carcinoma, collectively termed non-melanoma skin cancers are the most
commonmalignant tumors in humans. Basal cell carcinoma grows slowly and metastatic spread is very rare. Squamous
cell carcinoma is characterized by infiltrative, destructive growth and metastasis. Long-term exposure of skin to UV light
has a great impact on development of these epidermal malignancies. UV light induces cascade of events like well known
DNA damage of keratinocytes as well as still completely undetermined influence on apoptotic process through expression
of proapoptotic and antiapoptotic molecules. The major role in development of skin cancer is given to proapoptotic p53
molecule or tumor suppressor gene which mutation due to UV exposure leads to resistance of DNA-damaged cell to
apoptosis. Other proapoptotic molecules such as Fas ligand (FasL) and tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL) are strongly expressed in basal cell carcinoma and squamous cell carcinoma that could be explained by
the ability of tumor to escape the attack of immune system.

Ključne riječi
basal cell carcinoma; squamous cell carcinoma; ultraviolet light; apoptosis; p53; FasL

Hrčak ID: 27430

URI
https://hrcak.srce.hr/27430

Posjeta: 447 *