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Effect of radioprotective and chemoprotective drug (WR-2721) on toxicity of acetaminophen in mice

Joško Aleksić ; Knin General Hospital, Knin, Croatia
Domagoj Vergles ; Dubrava University Hospital, Zagreb, Croatia
Filip Čulo ; School of Medicine, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (82 KB) str. 107-109 preuzimanja: 472* citiraj
APA 6th Edition
Aleksić, J., Vergles, D. i Čulo, F. (2008). Effect of radioprotective and chemoprotective drug (WR-2721) on toxicity of acetaminophen in mice. Periodicum biologorum, 110 (1), 107-109. Preuzeto s https://hrcak.srce.hr/29288
MLA 8th Edition
Aleksić, Joško, et al. "Effect of radioprotective and chemoprotective drug (WR-2721) on toxicity of acetaminophen in mice." Periodicum biologorum, vol. 110, br. 1, 2008, str. 107-109. https://hrcak.srce.hr/29288. Citirano 04.12.2020.
Chicago 17th Edition
Aleksić, Joško, Domagoj Vergles i Filip Čulo. "Effect of radioprotective and chemoprotective drug (WR-2721) on toxicity of acetaminophen in mice." Periodicum biologorum 110, br. 1 (2008): 107-109. https://hrcak.srce.hr/29288
Harvard
Aleksić, J., Vergles, D., i Čulo, F. (2008). 'Effect of radioprotective and chemoprotective drug (WR-2721) on toxicity of acetaminophen in mice', Periodicum biologorum, 110(1), str. 107-109. Preuzeto s: https://hrcak.srce.hr/29288 (Datum pristupa: 04.12.2020.)
Vancouver
Aleksić J, Vergles D, Čulo F. Effect of radioprotective and chemoprotective drug (WR-2721) on toxicity of acetaminophen in mice. Periodicum biologorum [Internet]. 2008 [pristupljeno 04.12.2020.];110(1):107-109. Dostupno na: https://hrcak.srce.hr/29288
IEEE
J. Aleksić, D. Vergles i F. Čulo, "Effect of radioprotective and chemoprotective drug (WR-2721) on toxicity of acetaminophen in mice", Periodicum biologorum, vol.110, br. 1, str. 107-109, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/29288. [Citirano: 04.12.2020.]

Sažetak
Background and Purpose: It is known that WR-2721 WR-2721 – [S-2-(3-aminopropylamino)ethylposphorothioate] has radioprotective and chemoprotective effects on non-tumor tissues, and is now introduced into clinical tumor therapy protocols.We investigated whetherWR-2721 have a protective role in acute liver injury induced with acetaminophen (APAP).

Materials and Methods: CBA/H Zgr inbred mice of both sexes aged 12–16 weeks, weighing 20–25 g were used. Mice were given phenobarbitone- sodium in drinking water during 7 days (300 mg/kg) in order to induce hepatic drug-metabolizing enzymes. Thereafter, mice were fasted overnight andWR-2721 was given i.p. (50, 100 or 200 mg/kg). After 15–30 minutes they received acetaminophen (APAP; Paracetamol) 200 mg/kg by gastric tube. Animals were allowed food 4 hours later. The mortality of mice was followed for 3 days and serum aminotransferase levels were determined 24 hours after APAP administration.

Results: Survival of mice was prolonged after all doses ofWR-2721, but significantly only after the dose of 100 mg/kg of WR-2721. Similarly, the pretreatment of mice with 100 mg/kg of WR-2721 highly significantly reduced serum aspartate aminotransferase levels (AST, p<0. 0005) and serum alanine aminotransferase levels (ALT, p<0.005). The doses of 50 and 200 mg/kg of WR-2721 also reduced AST and ALT, but not significantly.

Conclusions: These data showed that WR-2721 has definitive hepatoprotective effect which is significant in very restricted dose range.

Hrčak ID: 29288

URI
https://hrcak.srce.hr/29288

Posjeta: 721 *