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https://doi.org/10.2478/10004-1254-59-2008-1907

Asbestosis and Catalase Genetic Polymorphism

Alenka Franko ; Clinical Institute of Occupational, Traffic and Sports Medicine, University Medical Centre, Ljubljana, Slovenia
Vita Dolžan ; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Niko Arnerić ; Clinical Institute of Occupational, Traffic and Sports Medicine, University Medical Centre, Ljubljana, Slovenia
Metoda Dodič-Fikfak ; Clinical Institute of Occupational, Traffic and Sports Medicine, University Medical Centre, Ljubljana, Slovenia

Puni tekst: engleski, pdf (81 KB) str. 233-240 preuzimanja: 616* citiraj
APA 6th Edition
Franko, A., Dolžan, V., Arnerić, N. i Dodič-Fikfak, M. (2008). Asbestosis and Catalase Genetic Polymorphism. Arhiv za higijenu rada i toksikologiju, 59 (4), 233-240. https://doi.org/10.2478/10004-1254-59-2008-1907
MLA 8th Edition
Franko, Alenka, et al. "Asbestosis and Catalase Genetic Polymorphism." Arhiv za higijenu rada i toksikologiju, vol. 59, br. 4, 2008, str. 233-240. https://doi.org/10.2478/10004-1254-59-2008-1907. Citirano 26.09.2020.
Chicago 17th Edition
Franko, Alenka, Vita Dolžan, Niko Arnerić i Metoda Dodič-Fikfak. "Asbestosis and Catalase Genetic Polymorphism." Arhiv za higijenu rada i toksikologiju 59, br. 4 (2008): 233-240. https://doi.org/10.2478/10004-1254-59-2008-1907
Harvard
Franko, A., et al. (2008). 'Asbestosis and Catalase Genetic Polymorphism', Arhiv za higijenu rada i toksikologiju, 59(4), str. 233-240. https://doi.org/10.2478/10004-1254-59-2008-1907
Vancouver
Franko A, Dolžan V, Arnerić N, Dodič-Fikfak M. Asbestosis and Catalase Genetic Polymorphism. Arh Hig Rada Toksikol. [Internet]. 2008 [pristupljeno 26.09.2020.];59(4):233-240. https://doi.org/10.2478/10004-1254-59-2008-1907
IEEE
A. Franko, V. Dolžan, N. Arnerić i M. Dodič-Fikfak, "Asbestosis and Catalase Genetic Polymorphism", Arhiv za higijenu rada i toksikologiju, vol.59, br. 4, str. 233-240, 2008. [Online]. https://doi.org/10.2478/10004-1254-59-2008-1907

Sažetak
Catalase (CAT) is part of the enzymatic defense system against reactive oxygen species (ROS), known to be involved in the pathogenesis of asbestosis. This study investigates whether CAT -262 C>T genetic polymorphism influences the risk of asbestosis in workers occupationally exposed to asbestos.
The nested case-control study included 262 cases with asbestosis and 265 controls with no asbestosrelated disease. Data on cumulative asbestos exposure and smoking were available. A real-time PCR assay was introduced for genotyping CAT -262 C>T promoter polymorphism.
A slightly elevated risk of asbestosis was observed in subjects with the CAT -262 TT genotype compared to others (OR=1.36, CI 0.70-2.62). This risk did not change substantially after adjustment by sex, age, and smoking, but the involvement of cumulative asbestos exposure changed the OR to 1.91 (CI 0.93-3.91).
These findings indicate that the CAT -262 TT genotype may be slightly associated with an increased risk of asbestosis. No synergistic effect was found between cumulative asbestos exposure and the CAT -262 TT genotype, but cumulative asbestos exposure acted as a confounder. These results are an important contribution to understanding the interactions between genetic and environmental factors that may modify the risk of asbestosis.

Ključne riječi
asbestos exposure; causal relationship; nested case control study; real-time PCR

Hrčak ID: 29524

URI
https://hrcak.srce.hr/29524

[slovenski]

Posjeta: 1.035 *