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Acta Pharmaceutica, Vol. 59 No. 2, 2009.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0011-1

Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties

ASIF HUSAIN ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
MOHAMMED AJMAL ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India

Puni tekst: engleski, pdf (84 KB) str. 223-233 preuzimanja: 4.679* citiraj
APA 6th Edition
HUSAIN, A. i AJMAL, M. (2009). Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties. Acta Pharmaceutica, 59 (2), 223-233. https://doi.org/10.2478/v10007-009-0011-1
MLA 8th Edition
HUSAIN, ASIF i MOHAMMED AJMAL. "Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 223-233. https://doi.org/10.2478/v10007-009-0011-1. Citirano 26.05.2019.
Chicago 17th Edition
HUSAIN, ASIF i MOHAMMED AJMAL. "Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties." Acta Pharmaceutica 59, br. 2 (2009): 223-233. https://doi.org/10.2478/v10007-009-0011-1
Harvard
HUSAIN, A., i AJMAL, M. (2009). 'Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties', Acta Pharmaceutica, 59(2), str. 223-233. doi: https://doi.org/10.2478/v10007-009-0011-1
Vancouver
HUSAIN A, AJMAL M. Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties. Acta Pharm. [Internet]. 2009 [pristupljeno 26.05.2019.];59(2):223-233. doi: https://doi.org/10.2478/v10007-009-0011-1
IEEE
A. HUSAIN i M. AJMAL, "Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties", Acta Pharmaceutica, vol.59, br. 2, str. 223-233, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0011-1

Sažetak
A novel series of 2-[3-(4-bromophenyl)propan-3-one]-5-(substituted phenyl)-1,3,4-oxadiazoles (4a-n) have been synthesized from 3-(4-bromobenzoyl)propionic acid (3) with the aim to get better anti-inflammatory and analgesic agents with minimum or without side effects (ulcerogenicity). Compound 3 was reacted with several aryl acid hydrazides (2a-n) in phosphorous oxychloride to obtain the title compounds. Structures of the synthesized compounds were supported by means of IR, 1H NMR and mass spectroscopy. Title compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antibacterial activities. Antibacterial activity was expressed as the corresponding minimum inhibitory concentration (MIC) values. A fair number of compounds were found to have significant anti-inflammatory and analgesic activities, while a few compounds showed appreciable antibacterial activity. The newly synthesized compounds showed very low ulcerogenic action. The findings of the present study indicate that cyclization of the carboxylic group of 3 into novel 1,3,4-oxadiazole nucleus resulted in increased anti-inflammatory and analgesic activities with significant decrease of ulcerogenic activity.

Ključne riječi
1,3,4-oxadiazoles; aroylpropionic acid; anti-inflammatory; analgesic activity; antibacterial activity

Hrčak ID: 33073

URI
https://hrcak.srce.hr/33073

[hrvatski]

Posjeta: 5.057 *