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ACQUIRED GENETIC CHANGES IN SECONDARY TUMOR DISEASES

Iskra Petković ; Klinika za dječje bolesti Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, Zagreb

Puni tekst: engleski, doc (130 KB) str. 235-235 preuzimanja: 1.631* citiraj
APA 6th Edition
Petković, I. (2008). ACQUIRED GENETIC CHANGES IN SECONDARY TUMOR DISEASES. Paediatria Croatica, 52 (4), 235-235. Preuzeto s https://hrcak.srce.hr/34968
MLA 8th Edition
Petković, Iskra. "ACQUIRED GENETIC CHANGES IN SECONDARY TUMOR DISEASES." Paediatria Croatica, vol. 52, br. 4, 2008, str. 235-235. https://hrcak.srce.hr/34968. Citirano 22.09.2020.
Chicago 17th Edition
Petković, Iskra. "ACQUIRED GENETIC CHANGES IN SECONDARY TUMOR DISEASES." Paediatria Croatica 52, br. 4 (2008): 235-235. https://hrcak.srce.hr/34968
Harvard
Petković, I. (2008). 'ACQUIRED GENETIC CHANGES IN SECONDARY TUMOR DISEASES', Paediatria Croatica, 52(4), str. 235-235. Preuzeto s: https://hrcak.srce.hr/34968 (Datum pristupa: 22.09.2020.)
Vancouver
Petković I. ACQUIRED GENETIC CHANGES IN SECONDARY TUMOR DISEASES. Paediatria Croatica [Internet]. 2008 [pristupljeno 22.09.2020.];52(4):235-235. Dostupno na: https://hrcak.srce.hr/34968
IEEE
I. Petković, "ACQUIRED GENETIC CHANGES IN SECONDARY TUMOR DISEASES", Paediatria Croatica, vol.52, br. 4, str. 235-235, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/34968. [Citirano: 22.09.2020.]
Puni tekst: hrvatski, doc (130 KB) str. 231-234 preuzimanja: 367* citiraj
APA 6th Edition
Petković, I. (2008). STEČENI POREMEĆAJI GENOMA SEKUNDARNIH TUMORSKIH BOLESTI. Paediatria Croatica, 52 (4), 231-234. Preuzeto s https://hrcak.srce.hr/34968
MLA 8th Edition
Petković, Iskra. "STEČENI POREMEĆAJI GENOMA SEKUNDARNIH TUMORSKIH BOLESTI." Paediatria Croatica, vol. 52, br. 4, 2008, str. 231-234. https://hrcak.srce.hr/34968. Citirano 22.09.2020.
Chicago 17th Edition
Petković, Iskra. "STEČENI POREMEĆAJI GENOMA SEKUNDARNIH TUMORSKIH BOLESTI." Paediatria Croatica 52, br. 4 (2008): 231-234. https://hrcak.srce.hr/34968
Harvard
Petković, I. (2008). 'STEČENI POREMEĆAJI GENOMA SEKUNDARNIH TUMORSKIH BOLESTI', Paediatria Croatica, 52(4), str. 231-234. Preuzeto s: https://hrcak.srce.hr/34968 (Datum pristupa: 22.09.2020.)
Vancouver
Petković I. STEČENI POREMEĆAJI GENOMA SEKUNDARNIH TUMORSKIH BOLESTI. Paediatria Croatica [Internet]. 2008 [pristupljeno 22.09.2020.];52(4):231-234. Dostupno na: https://hrcak.srce.hr/34968
IEEE
I. Petković, "STEČENI POREMEĆAJI GENOMA SEKUNDARNIH TUMORSKIH BOLESTI", Paediatria Croatica, vol.52, br. 4, str. 231-234, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/34968. [Citirano: 22.09.2020.]

Sažetak
Recent years have seen significant progress in the treatment of patients with malignancies, but have increased the risk of late complications including secondary cancers. Frequent complications are therapy related myelodysplastic syndrome (tMDS) and acute myeloid leukaemia (tAML). This article reviews the results published so far of genetic investigations of patients with tMDS and tAML. The review focuses on acquired genetic changes, specific clonal chromosomal aberrations, gene mutations, current knowledge of the relationship between cytotoxic agents used in previous treatment with genome abnormalities, and classification of tMDS/tAML according to genetic and clinical characteristics. The available results indicate that cytogenetic and molecular analysis have clinical usefulness in the diagnosis and management of patients with tMDS/tAMl, they contribute to the understanding of leukemogenesis and the role of cytotoxic agents in the etiology of acute leukaemia.

Ključne riječi
Descriptors: NEOPLASMS, SECOND PRIMARY – etiology, genetics; LEUKEMIA, MYELOID, ACUTE - etiology, genetics; MYELODYSPLASTIC SYNDROMES - etiology, genetics; ANTINEOPLASTIC AGENTS – adverse effects; CHROMOSOME ABERRATIONS

Hrčak ID: 34968

URI
https://hrcak.srce.hr/34968

[hrvatski]

Posjeta: 2.313 *