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Preoperative Clonidine or Levobupivacaine – Effect on Systemic Inflammatory Stress Response

Jasminka Peršec ; Anesthesiology, Resuscitation and Intensive Care Medicine Clinic, University Hospital »Dubrava«, Zagreb, Croatia
Zoran Peršec ; Department of Urology, University Hospital »Dubrava«, Zagreb, Croatia
Damir Buković ; Department of Gynecology and Obstetrics, University Hospital Center »Zagreb«, Zagreb, Croatia
Vlasta Merc ; Anesthesiology, Resuscitation and Intensive Care Medicine Clinic, University Hospital »Dubrava«, Zagreb, Croatia
Jasminka Pavelić ; Institute »Rudjer Bo{kovi}«, Division of Molecular Medicine, Zagreb, Croatia
Tomislav Zupić ; Department of Gynecology and Obstetrics, University Hospital Center »Zagreb«, Zagreb, Croatia

Puni tekst: engleski, pdf (61 KB) str. 573-577 preuzimanja: 234* citiraj
APA 6th Edition
Peršec, J., Peršec, Z., Buković, D., Merc, V., Pavelić, J. i Zupić, T. (2009). Preoperative Clonidine or Levobupivacaine – Effect on Systemic Inflammatory Stress Response. Collegium antropologicum, 33 (2), 573-577. Preuzeto s https://hrcak.srce.hr/40557
MLA 8th Edition
Peršec, Jasminka, et al. "Preoperative Clonidine or Levobupivacaine – Effect on Systemic Inflammatory Stress Response." Collegium antropologicum, vol. 33, br. 2, 2009, str. 573-577. https://hrcak.srce.hr/40557. Citirano 23.01.2020.
Chicago 17th Edition
Peršec, Jasminka, Zoran Peršec, Damir Buković, Vlasta Merc, Jasminka Pavelić i Tomislav Zupić. "Preoperative Clonidine or Levobupivacaine – Effect on Systemic Inflammatory Stress Response." Collegium antropologicum 33, br. 2 (2009): 573-577. https://hrcak.srce.hr/40557
Harvard
Peršec, J., et al. (2009). 'Preoperative Clonidine or Levobupivacaine – Effect on Systemic Inflammatory Stress Response', Collegium antropologicum, 33(2), str. 573-577. Preuzeto s: https://hrcak.srce.hr/40557 (Datum pristupa: 23.01.2020.)
Vancouver
Peršec J, Peršec Z, Buković D, Merc V, Pavelić J, Zupić T. Preoperative Clonidine or Levobupivacaine – Effect on Systemic Inflammatory Stress Response. Collegium antropologicum [Internet]. 2009 [pristupljeno 23.01.2020.];33(2):573-577. Dostupno na: https://hrcak.srce.hr/40557
IEEE
J. Peršec, Z. Peršec, D. Buković, V. Merc, J. Pavelić i T. Zupić, "Preoperative Clonidine or Levobupivacaine – Effect on Systemic Inflammatory Stress Response", Collegium antropologicum, vol.33, br. 2, str. 573-577, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/40557. [Citirano: 23.01.2020.]

Sažetak
With perioperative pain control it is possible to supervise immune system, release of inflammation mediators, and influence on treatment outcome. Use of analgetics before the pain stimulus (preventive analgesia) obstruct development of neuroplastic changes in central nervous system, and reduces pain. Investigation hypothesis was that preoperative epidural clonidine is more efficient in blockade of systemic inflammatory stress response comparing to levobupivacaine. Patients were allocated to three groups, according to preoperative epidural use of clonidine, levobupivacaine or saline (control group). Before operation, 1 h after the beginning, 1 h, 6 h, 12 h and 24 h after the operation following parameters were analyzed: interleukine-6, C-reactive protein and leukocyte count. There were no significant differences between groups in age, gender, body mass index and operation time. In preoperative clonidine group, we found significant reduction in interleukine-6 levels throughout investigation time, compared to preoperative levobupivacaine group and control group. Also, C-reactive protein was significantly lower at the end of investigation, compared to other two groups. Leukocyte count was lower, and within the normal range in all investigation times only in preoperative clonidine group. We demonstrated significant difference that support importance of clonidine central effect on pain pathways and systemic inflammatory blockade.

Ključne riječi
clonidine; levobupivacaine; systemic inflammatory stress response; epidural analgesia

Hrčak ID: 40557

URI
https://hrcak.srce.hr/40557

Posjeta: 457 *