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Acta Pharmaceutica, Vol. 60 No. 2, 2010.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0017-8

Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods

D. Nagavalli ; Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319, Kanchipuram District, Tamil Nadu, India
V. Vaidhyalingam ; Madras Medical College, Chennai-600003, India
A. Santha ; C. L. Baid Metha College of Pharmacy, Chennai-600 096. Tamil Nadu, India
A. S. K. Sankar ; Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319, Kanchipuram District, Tamil Nadu, India
O. Divya ; IIT, Chennai-600 036, Tamil Nadu, India

Puni tekst: engleski, pdf (104 KB) str. 141-152 preuzimanja: 1.723* citiraj
APA 6th Edition
Nagavalli, D., Vaidhyalingam, V., Santha, A., Sankar, A.S.K. i Divya, O. (2010). Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods. Acta Pharmaceutica, 60 (2), 141-152. https://doi.org/10.2478/v10007-010-0017-8
MLA 8th Edition
Nagavalli, D., et al. "Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods." Acta Pharmaceutica, vol. 60, br. 2, 2010, str. 141-152. https://doi.org/10.2478/v10007-010-0017-8. Citirano 22.02.2019.
Chicago 17th Edition
Nagavalli, D., V. Vaidhyalingam, A. Santha, A. S. K. Sankar i O. Divya. "Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods." Acta Pharmaceutica 60, br. 2 (2010): 141-152. https://doi.org/10.2478/v10007-010-0017-8
Harvard
Nagavalli, D., et al. (2010). 'Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods', Acta Pharmaceutica, 60(2), str. 141-152. doi: https://doi.org/10.2478/v10007-010-0017-8
Vancouver
Nagavalli D, Vaidhyalingam V, Santha A, Sankar ASK, Divya O. Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods. Acta Pharm. [Internet]. 2010 [pristupljeno 22.02.2019.];60(2):141-152. doi: https://doi.org/10.2478/v10007-010-0017-8
IEEE
D. Nagavalli, V. Vaidhyalingam, A. Santha, A.S.K. Sankar i O. Divya, "Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods", Acta Pharmaceutica, vol.60, br. 2, str. 141-152, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0017-8

Sažetak
In the present work, four different spectrophotometric methods for simultaneous estimation of losartan potassium, amlodipine besilate and hydrochlorothiazide in raw materials and in formulations are described. Overlapped data was quantitatively resolved by using chemometric methods, classical least squares (CLS), multiple linear regression (MLR), principal component regression (PCR) and partial least squares (PLS). Calibrations were constructed using the absorption data matrix corresponding to the concentration data matrix, with measurements in the range of 230.5350.4 nm (∆λ = 0.1 nm) in their zero order spectra. The linearity range was found to be 840, 15 and 315 μg ml1 for losartan potassium, amlodipine besilate and hydrochlorothiazide, respectively. The validity of the proposed methods was successfully assessed for analyses of drugs in the various prepared physical mixtures and in tablet formulations.

Ključne riječi
losartan; amlodipine besilate; hydrochlorothiazide; spectrophotometry; chemometry

Hrčak ID: 48383

URI
https://hrcak.srce.hr/48383

[hrvatski]

Posjeta: 2.227 *