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Arhiv za higijenu rada i toksikologiju, Vol. 61 No. 1, 2010.

Kratko priopćenje
https://doi.org/10.2478/10004-1254-61-2010-1985

Qualitative GC-MS Assessment of TCP and TAMORF Elimination in Rats

Maja Jelena Petek   ORCID icon orcid.org/0000-0002-3659-1725 ; Forensic Science Centre “Ivan Vučetić”, Zagreb, Croatia
Ana Lucić Vrdoljak ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Gordan Mršić ; Forensic Science Centre “Ivan Vučetić”, Zagreb, Croatia

Puni tekst: engleski, pdf (193 KB) str. 61-66 preuzimanja: 293* citiraj
APA 6th Edition
Petek, M.J., Lucić Vrdoljak, A. i Mršić, G. (2010). Qualitative GC-MS Assessment of TCP and TAMORF Elimination in Rats. Arhiv za higijenu rada i toksikologiju, 61 (1), 61-66. https://doi.org/10.2478/10004-1254-61-2010-1985
MLA 8th Edition
Petek, Maja Jelena, et al. "Qualitative GC-MS Assessment of TCP and TAMORF Elimination in Rats." Arhiv za higijenu rada i toksikologiju, vol. 61, br. 1, 2010, str. 61-66. https://doi.org/10.2478/10004-1254-61-2010-1985. Citirano 20.02.2019.
Chicago 17th Edition
Petek, Maja Jelena, Ana Lucić Vrdoljak i Gordan Mršić. "Qualitative GC-MS Assessment of TCP and TAMORF Elimination in Rats." Arhiv za higijenu rada i toksikologiju 61, br. 1 (2010): 61-66. https://doi.org/10.2478/10004-1254-61-2010-1985
Harvard
Petek, M.J., Lucić Vrdoljak, A., i Mršić, G. (2010). 'Qualitative GC-MS Assessment of TCP and TAMORF Elimination in Rats', Arhiv za higijenu rada i toksikologiju, 61(1), str. 61-66. doi: https://doi.org/10.2478/10004-1254-61-2010-1985
Vancouver
Petek MJ, Lucić Vrdoljak A, Mršić G. Qualitative GC-MS Assessment of TCP and TAMORF Elimination in Rats. Arh Hig Rada Toksikol. [Internet]. 2010 [pristupljeno 20.02.2019.];61(1):61-66. doi: https://doi.org/10.2478/10004-1254-61-2010-1985
IEEE
M.J. Petek, A. Lucić Vrdoljak i G. Mršić, "Qualitative GC-MS Assessment of TCP and TAMORF Elimination in Rats", Arhiv za higijenu rada i toksikologiju, vol.61, br. 1, str. 61-66, 2010. [Online]. doi: https://doi.org/10.2478/10004-1254-61-2010-1985

Sažetak
Nerve agents are highly toxic organophosphorus (OP) compounds. They inhibit acetylcholinesterase (AChE), an enzyme that hydrolyses acetycholine (ACh) in the nervous system. Pathophysiological changes caused by OP poisonings are primarily the consequence of surplus ACh on cholinergic receptors and in the central nervous system. Standard treatment of OP poisoning includes combined administration of carbamates, atropine, oximes and anticonvulsants. In order to improve therapy, new compounds have been synthesised and tested. Tenocyclidine (TCP) and its adamantane derivative 1-[2-(2-thienyl)-2-adamantyl] morpholine (TAMORF) have shown interesting properties against soman poisoning. In this study, we
developed a qualitative GC-MS method to measure elimination of TCP and TAMORF through rat urine in order to learn more about the mechanisms through which TCP protects an organism from OP poisoning and to determine the duration of this protective effect. GC-MS showed that six hours after treatment with TCP, rat urine contained only its metabolite 1-thienylcyclohexene, while urine of rats treated with TAMORF contained both TAMORF and its metabolites.

Ključne riječi
antidote; metabolite; qualitative method; urine; tenocyclidine

Hrčak ID: 49020

URI
https://hrcak.srce.hr/49020

[hrvatski]

Posjeta: 661 *