Paediatria Croatica, Vol. 54 No. 1, 2010.
Izvorni znanstveni članak
THE ROLE OF ELECTIVE SURGERY IN CHILDREN WITH LOCALIZED CROHN’S DISEASE
Iva Hojsak
; Klinika za dječje bolesti Zagreb
Dujo Kovačević
; Klinička bolnica "Sestre Milosrdnice"
Zrinjka Mišak
; Klinika za dječje bolesti Zagreb
Andrija Car
; Klinika za dječje bolesti Zagreb
Sanja Kolaček
; Klinika za dječje bolesti Zagreb
Sažetak
Background: Substantial proportions of children with Crohn’s Disease (CD) are non-responsive to standard medical therapy
and/or nutritional treatment. For many children impairment of growth will also be an associated medical problem.
Aim: The aim of our study was to investigate a role of elective surgical treatment on the induction and duration of remission,
and on growth improvement in paediatric patients with localized CD, who were refractory to conservative treatment.
Methods: We retrospectively analyzed the data of 55 newly diagnosed CD patients among whom 22 children (40%) had undergone
surgical treatment.
Results: Post surgery all patients had significant PCDAI decline and the great majority of them (90.9%) had stable remission
for more than 2 years. Following surgery 86.4% patients had a significant improvement in growth: an improvement in Z score for
height ranging from 0.2 to 0.5 SD (9 months to 2 years after resection, p<0,01).
Conclusion: Elective surgery, if properly timed and in well prepared patients, has a significant relapse preventive and steroid
sparing role, and also results in major growth improvement.
Ključne riječi
Descriptors: SURGICAL PROCEDURES, OPERATIVE; CROHN DISEASE – surgery
Hrčak ID:
49747
URI
Datum izdavanja:
18.3.2010.
Posjeta: 908 *