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https://doi.org/10.2478/v10007-010-0025-8

Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets

MADHUSUDHAN MALLADI ; CPS Formulations, DR. Reddy’s Laboratories Limited, Bachupally, Hyderabad-500090, India
RAJU JUKANTI ; Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal-506001, India
RASHMI NAIR ; CPS Formulations, DR. Reddy’s Laboratories Limited, Bachupally, Hyderabad-500090, India
SANJAY WAGH ; CPS Formulations, DR. Reddy’s Laboratories Limited, Bachupally, Hyderabad-500090, India
HARI SHANKER PADAKANTI ; Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal-506001, India
ASHOK MATETI ; Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal-506001, India

Puni tekst: engleski, pdf (168 KB) str. 267-280 preuzimanja: 1.451* citiraj
APA 6th Edition
MALLADI, M., JUKANTI, R., NAIR, R., WAGH, S., PADAKANTI, H.S. i MATETI, A. (2010). Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets. Acta Pharmaceutica, 60 (3), 267-280. https://doi.org/10.2478/v10007-010-0025-8
MLA 8th Edition
MALLADI, MADHUSUDHAN, et al. "Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets." Acta Pharmaceutica, vol. 60, br. 3, 2010, str. 267-280. https://doi.org/10.2478/v10007-010-0025-8. Citirano 26.06.2019.
Chicago 17th Edition
MALLADI, MADHUSUDHAN, RAJU JUKANTI, RASHMI NAIR, SANJAY WAGH, HARI SHANKER PADAKANTI i ASHOK MATETI. "Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets." Acta Pharmaceutica 60, br. 3 (2010): 267-280. https://doi.org/10.2478/v10007-010-0025-8
Harvard
MALLADI, M., et al. (2010). 'Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets', Acta Pharmaceutica, 60(3), str. 267-280. doi: https://doi.org/10.2478/v10007-010-0025-8
Vancouver
MALLADI M, JUKANTI R, NAIR R, WAGH S, PADAKANTI HS, MATETI A. Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets. Acta Pharm. [Internet]. 2010 [pristupljeno 26.06.2019.];60(3):267-280. doi: https://doi.org/10.2478/v10007-010-0025-8
IEEE
M. MALLADI, R. JUKANTI, R. NAIR, S. WAGH, H.S. PADAKANTI i A. MATETI, "Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets", Acta Pharmaceutica, vol.60, br. 3, str. 267-280, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0025-8

Sažetak
The present study is aimed to develop dextromethorphan hydrobromide (DXM) oral disintegrating tablets (ODT) with acceptable palatability to help patients of all age group. The bitter taste of the drug was masked by binding the drug to ion exchange resin. The effect of particle size of resin on drug loading was studied. In vitro and in vivo disintegration time and in vitro drug release studies were performed. Drug loading increased significantly with a decrease in the particle size of the resin. DSC and XRPD studies reveal that the molecular state of the drug changed from crystalline to amorphous form. The dissolution efficiency calulated for optimized ODT and conventional directly compressed tablet were almost comparable, indicating free dissociation of the drug from the resinate. The bitter taste of DXM can be masked by binding with ion exchange resin and the resinate can be successfully formulated into oral disintegrating tablets.

Ključne riječi
dextromethorphan hydrobromide; ion exchange resin; taste masking; superdisintegrants

Hrčak ID: 53495

URI
https://hrcak.srce.hr/53495

[hrvatski]

Posjeta: 1.982 *