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Acta Pharmaceutica, Vol. 61 No. 1, 2011.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-011-0004-8

Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma

VANDANA GUPTA ; School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal (MP)-462036, India
RAMESH CHANDRA Agrawal ; Jawaharlal Nehru Cancer Hospital and Research Center, Post Box. No. 32, Idgah Hills, Bhopal-462001 (MP) India
PIYUSH TRIVEDI ; School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal (MP)-462036, India

Puni tekst: engleski, pdf (126 KB) str. 63-71 preuzimanja: 409* citiraj
APA 6th Edition
GUPTA, V., Agrawal, R.C. i TRIVEDI, P. (2011). Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma. Acta Pharmaceutica, 61 (1), 63-71. https://doi.org/10.2478/v10007-011-0004-8
MLA 8th Edition
GUPTA, VANDANA, et al. "Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma." Acta Pharmaceutica, vol. 61, br. 1, 2011, str. 63-71. https://doi.org/10.2478/v10007-011-0004-8. Citirano 21.02.2019.
Chicago 17th Edition
GUPTA, VANDANA, RAMESH CHANDRA Agrawal i PIYUSH TRIVEDI. "Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma." Acta Pharmaceutica 61, br. 1 (2011): 63-71. https://doi.org/10.2478/v10007-011-0004-8
Harvard
GUPTA, V., Agrawal, R.C., i TRIVEDI, P. (2011). 'Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma', Acta Pharmaceutica, 61(1), str. 63-71. doi: https://doi.org/10.2478/v10007-011-0004-8
Vancouver
GUPTA V, Agrawal RC, TRIVEDI P. Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma. Acta Pharm. [Internet]. 2011 [pristupljeno 21.02.2019.];61(1):63-71. doi: https://doi.org/10.2478/v10007-011-0004-8
IEEE
V. GUPTA, R.C. Agrawal i P. TRIVEDI, "Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma", Acta Pharmaceutica, vol.61, br. 1, str. 63-71, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0004-8

Sažetak
Cisplatin-loaded protransfersome system was prepared and characterized for in vitro drug permeation, drug deposition and antitumor effect. A histopathological study and a genotoxicity study were also done. The skin permeation data from protransfersome gel formulation of cisplatin revealed 494.33 ± 11.87 µg cm-2 drug permeation, which was significantly higher than that from the control plain drug solution in 0.9 % NaCl (p < 0.001). Untreated group of animals showed invasive moderately differentiated keratinizing squamous cell carcinoma (malignant stage). However, with cisplatin loaded protransfersome gel system simple epithelial hyperplasia (pre-cancerous stage) with no cancerous growth was observed. Also, a significant induction in micronucleus formation was found in the group that was treated with injectable intraperitoneal cisplatin preparation in 0.9 % saline as compared to the group treated with topical protransfersome gel formulation. The findings of this research work appears to support the improved, site-specific and localized drug action in the skin, thus providing a better option to deal with skin related problems like squamous cell carcinoma.

Ključne riječi
cisplatin; protransfersome; topical chemotherapy; genetic damage; bone marrow cells; micronucleated polychromatic erythrocytes

Hrčak ID: 63373

URI
https://hrcak.srce.hr/63373

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