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ICTP in Bone Metastases of Lung Cancer

Ana Franjević
Radomir Pavićević
Gordana Bubanović

Puni tekst: engleski, pdf (113 KB) str. 43-47 preuzimanja: 171* citiraj
APA 6th Edition
Franjević, A., Pavićević, R. i Bubanović, G. (2011). ICTP in Bone Metastases of Lung Cancer. Collegium antropologicum, 35 (1), 43-47. Preuzeto s https://hrcak.srce.hr/64730
MLA 8th Edition
Franjević, Ana, et al. "ICTP in Bone Metastases of Lung Cancer." Collegium antropologicum, vol. 35, br. 1, 2011, str. 43-47. https://hrcak.srce.hr/64730. Citirano 19.11.2019.
Chicago 17th Edition
Franjević, Ana, Radomir Pavićević i Gordana Bubanović. "ICTP in Bone Metastases of Lung Cancer." Collegium antropologicum 35, br. 1 (2011): 43-47. https://hrcak.srce.hr/64730
Harvard
Franjević, A., Pavićević, R., i Bubanović, G. (2011). 'ICTP in Bone Metastases of Lung Cancer', Collegium antropologicum, 35(1), str. 43-47. Preuzeto s: https://hrcak.srce.hr/64730 (Datum pristupa: 19.11.2019.)
Vancouver
Franjević A, Pavićević R, Bubanović G. ICTP in Bone Metastases of Lung Cancer. Collegium antropologicum [Internet]. 2011 [pristupljeno 19.11.2019.];35(1):43-47. Dostupno na: https://hrcak.srce.hr/64730
IEEE
A. Franjević, R. Pavićević i G. Bubanović, "ICTP in Bone Metastases of Lung Cancer", Collegium antropologicum, vol.35, br. 1, str. 43-47, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/64730. [Citirano: 19.11.2019.]

Sažetak
Bone metastases often appear in advanced stages of lung cancer. They are the result of modulation of bone metabolism
by tumor cells that migrated into bone microenvironment and degraded bone organic matrix. Measurement of C-terminal
telopeptide of type I collagen (ICTP) in the serum of subjects with lung cancer with and without bone metastases and
healthy population is the way to explore bone resorption. In 343 subjects included in this research ICTP level was significantly
higher in the bone metastasis than other two groups. The existence of pathologic fracture significantly increased
ICTP level. ICTP showed sensitivity of 66.0% in bone metastases at 95.0% specificity in lung cancer stages IA and IB.
ICTP is a good diagnostic marker in detection of bone metastasis of lung cancer. Its level can distinguish lung cancer
with and without bone involvement and can be used as an addition to standard techniques used in diagnostics of bone
metastasis.

Ključne riječi
bone matrix; lung neoplasms; osteoclasts; osteolysis

Hrčak ID: 64730

URI
https://hrcak.srce.hr/64730

Posjeta: 302 *