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Waldenström's Macroglobulinemia as a Diagnostic Challenge: Case Report

Ivan Budimir
Marko Nikolić
Mateja Sabol Pušić
Davor Hrabar
Neven Ljubičić
Marko Duvnjak
Vladimir Supanc
Ivana Nikolac
Nenad Babić
Marija Šokčević

Puni tekst: engleski, pdf (208 KB) str. 94-97 preuzimanja: 598* citiraj
APA 6th Edition
Budimir, I., Nikolić, M., Sabol Pušić, M., Hrabar, D., Ljubičić, N., Duvnjak, M., ... Šokčević, M. (2014). Waldenström's Macroglobulinemia as a Diagnostic Challenge: Case Report. Acta clinica Croatica, 53. (1.), 94-97. Preuzeto s https://hrcak.srce.hr/126155
MLA 8th Edition
Budimir, Ivan, et al. "Waldenström's Macroglobulinemia as a Diagnostic Challenge: Case Report." Acta clinica Croatica, vol. 53., br. 1., 2014, str. 94-97. https://hrcak.srce.hr/126155. Citirano 28.01.2021.
Chicago 17th Edition
Budimir, Ivan, Marko Nikolić, Mateja Sabol Pušić, Davor Hrabar, Neven Ljubičić, Marko Duvnjak, Vladimir Supanc, Ivana Nikolac, Nenad Babić i Marija Šokčević. "Waldenström's Macroglobulinemia as a Diagnostic Challenge: Case Report." Acta clinica Croatica 53., br. 1. (2014): 94-97. https://hrcak.srce.hr/126155
Harvard
Budimir, I., et al. (2014). 'Waldenström's Macroglobulinemia as a Diagnostic Challenge: Case Report', Acta clinica Croatica, 53.(1.), str. 94-97. Preuzeto s: https://hrcak.srce.hr/126155 (Datum pristupa: 28.01.2021.)
Vancouver
Budimir I, Nikolić M, Sabol Pušić M, Hrabar D, Ljubičić N, Duvnjak M i sur. Waldenström's Macroglobulinemia as a Diagnostic Challenge: Case Report. Acta clinica Croatica [Internet]. 2014 [pristupljeno 28.01.2021.];53.(1.):94-97. Dostupno na: https://hrcak.srce.hr/126155
IEEE
I. Budimir, et al., "Waldenström's Macroglobulinemia as a Diagnostic Challenge: Case Report", Acta clinica Croatica, vol.53., br. 1., str. 94-97, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/126155. [Citirano: 28.01.2021.]

Sažetak
Waldenström’s macroglobulinemia is a distinct clinicopathologic entity defined as a B-cell neoplasm characterized by lymphoplasmacytic infiltrate in the bone marrow, with an associated immunoglobulin (Ig) M paraprotein. Clinical manifestations are due to deposition of IgM in the liver, spleen, and/or lymph nodes, so it presents with anemia, hyperviscosity, lymphadenopathy, hepatomegaly, splenomegaly and neurologic symptoms. The main diagnostic criteria are a typical peak on serum protein electrophoresis and malignant cells in bone marrow biopsy samples. There is no standard therapy for the treatment of symptomatic Waldenström’s macroglobulinemia and no agents have been specifically approved for this disease, but initial treatment usually starts with the monoclonal anti-CD20 antibody rituximab, either alone or in combination with other
agents, rather than chemotherapy alone. This article confirms that, despite the existence of more modern imaging methods, ultrasonography still has a significant diagnostic role.

Ključne riječi
Waldenström macroglobulinemia; B-lymphocytes; Immunogobulin M; Antibodies, monoclonal; Ultrasonography

Hrčak ID: 126155

URI
https://hrcak.srce.hr/126155

[hrvatski]

Posjeta: 1.408 *