Izvorni znanstveni članak

https://doi.org/10.5599/admet.2.4.155

Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers

Aneta Cernikova ; Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic
Radka Opatrilova ; Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic
Pavel Bobal ; Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic
Josef Jampilek orcid.org/0000-0003-2003-9052 ; Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic

Sažetak

The investigation deals with the influence of permeation of rutin from carboxymethyl cellulose gel through full-thickness pig ear skin by (S)- and (R)-alaptide as potential excipients. Alaptide, 8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. By means of this rapid screening it was found out that the permeation of rutin through the skin increased linearly with time and was enhanced by both enantiomers of alaptide: approx. 1.2-fold by (R)-alaptide and approx. 1.5-fold by (S)-alaptide.

Ključne riječi

(S)-Alaptide; (R)-alaptide; rutin; carboxymethylcellulose gel; skin permeation modifiers

Hrčak ID:

132858

URI

https://hrcak.srce.hr/132858

Datum izdavanja:

9.1.2015.

Posjeta: 1.573 *