hrcak mascot   Srce   HID

Kratko priopćenje
https://doi.org/10.5599/admet.3.4.209

Application of the Henderson-Hasselbalch equation to solubility determination: NSC-639829 Case Study

Samuel Yalkowsky ; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Arizona, Tucson, Arizona, USA
Raj Patel ; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Arizona, Tucson, Arizona, USA
Doaa Al-Antary ; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Arizona, Tucson, Arizona, USA

Puni tekst: engleski, pdf (517 KB) str. 359-362 preuzimanja: 1.484* citiraj
APA 6th Edition
Yalkowsky, S., Patel, R. i Al-Antary, D. (2015). Application of the Henderson-Hasselbalch equation to solubility determination: NSC-639829 Case Study. ADMET and DMPK, 3. (4.), 359-362. https://doi.org/10.5599/admet.3.4.209
MLA 8th Edition
Yalkowsky, Samuel, et al. "Application of the Henderson-Hasselbalch equation to solubility determination: NSC-639829 Case Study." ADMET and DMPK, vol. 3., br. 4., 2015, str. 359-362. https://doi.org/10.5599/admet.3.4.209. Citirano 18.09.2020.
Chicago 17th Edition
Yalkowsky, Samuel, Raj Patel i Doaa Al-Antary. "Application of the Henderson-Hasselbalch equation to solubility determination: NSC-639829 Case Study." ADMET and DMPK 3., br. 4. (2015): 359-362. https://doi.org/10.5599/admet.3.4.209
Harvard
Yalkowsky, S., Patel, R., i Al-Antary, D. (2015). 'Application of the Henderson-Hasselbalch equation to solubility determination: NSC-639829 Case Study', ADMET and DMPK, 3.(4.), str. 359-362. https://doi.org/10.5599/admet.3.4.209
Vancouver
Yalkowsky S, Patel R, Al-Antary D. Application of the Henderson-Hasselbalch equation to solubility determination: NSC-639829 Case Study. ADMET and DMPK [Internet]. 2015 [pristupljeno 18.09.2020.];3.(4.):359-362. https://doi.org/10.5599/admet.3.4.209
IEEE
S. Yalkowsky, R. Patel i D. Al-Antary, "Application of the Henderson-Hasselbalch equation to solubility determination: NSC-639829 Case Study", ADMET and DMPK, vol.3., br. 4., str. 359-362, 2015. [Online]. https://doi.org/10.5599/admet.3.4.209

Sažetak
A number of publications which challenge the applicability of the Henderson-Hasselbalch equation to
saturated solutions have appeared in the last few years (Avdeef [1-3], Butcher et al. [4], and Volgyi et al.
[5]). In the most recent of these, Butcher et al. [4] suggested “the Henderson-Hasselbalch equation may
not always be an accurate predictor of the pH dependence of solubility.” They claimed that the pKa of 4.70
determined by Jain et al. [6] for NSC-639829 is incorrect and that the value of 3.76, which they obtained by
extrapolation of spectrophotometrically determined pKa values in 22, 30, and 41 percent methanol-water
solutions, is the correct value. We believe that 4.70 is the correct value and that there are several serious
flaws in their analysis. These are described below.

Hrčak ID: 150560

URI
https://hrcak.srce.hr/150560

Posjeta: 1.613 *