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Agriculturae Conspectus Scientificus, Vol. 85 No. 4, 2020.

Izvorni znanstveni članak

Antioxidant, α-glucosidase and 15-lipoxygenases inhibitory activities of Cassia singueana Del. and C. sieberiana DC. (Fabaceae)

Saidu Jibril orcid id orcid.org/ORCID ; Department of Chemical Sciences, Faculty of Science, Federal University of Kashere, P. M. B. 0182, Gombe, Nigeria
Wan Mohd Nuzul Hakimi Wan Salleh orcid id orcid.org/ORCID ; Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak, Malaysia
Hasnah Mohd Sirat orcid id orcid.org/ORCID ; Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
Dalha Wada Taura orcid id orcid.org/ORCID ; Department of Microbiology, Faculty of Life Science, College of Pharmaceutical and Life Sciences, Bayero University Kano, P.M.B. 3011, Kano Nigeria
Yusha’u Muhammad orcid id orcid.org/ORCID ; Department of Microbiology, Faculty of Life Science, College of Pharmaceutical and Life Sciences, Bayero University Kano, P.M.B. 3011, Kano Nigeria
Abdu Zakari orcid id orcid.org/ORCID ; Department of Chemical Sciences, Faculty of Science, Federal University of Kashere, P. M. B. 0182, Gombe, Nigeria

Puni tekst: engleski pdf 541 Kb

str. 345-351

preuzimanja: 350

citiraj

Sažetak

The present study investigates the antioxidant, α-glucosidases, and anti-inflammatory properties of leaf extract of Cassia singueana and C. sieberiana. Cassia singueana and C. sieberiana are restorative plants utilised for the treatment of diabetes, ulcer, malaria, and wound healing. The extracts were evaluated for antioxidant activities via DPPH radical scavenging, ABTS+ radical cation scavenging, FRAP, β-carotene bleaching, phenolic content, and flavonoid content. Meanwhile, α-glucosidases and anti-inflammatory properties were also evaluated against α-glucosidase enzyme and 15-LOX inhibitory activities. The results for C. singueana extract revealed potent activities for DPPH (IC50: 9.35 µg/mL), phenolic contents (120.01 mg GAE/g dry extract), and α-glucosidases inhibition (I%: 90.47%). On the other hand, the findings for C. sieberiana recorded significant activities for FRAP (2120 µmol Fe2+/g dry extract) and 15-LOX inhibition (I%: 80.93%). The extract of C. singueana and C. sieberiana contain possible antioxidant, α-glucosidases, and anti-inflammatory agents that are responsible for the popular use of these plants in the treatment of diabetes and ulcer.

Ključne riječi

Cassia singueana, Cassia sieberiana, antioxidant, anti-inflammatory, anti-diabetic, Fabaceae

Hrčak ID:

245973

URI

https://hrcak.srce.hr/245973

Datum izdavanja:

10.11.2020.

Posjeta: 1.025 *