Original scientific paper
https://doi.org/10.2478/aiht-2021-72-3492
Chemical and biological characteristics of propolis from Apis mellifera caucasica from the Ardahan and Erzurum provinces of Turkey: a comparative study
Mehmet Arslan
; Ardahan University Faculty of Health Sciences, Department of Health Management, Ardahan, Turkey
Yusuf Sevgiler
orcid.org/0000-0002-4373-2389
; Adıyaman University Faculty of Science and Letters, Department of Biology, Adıyaman, Turkey
Celal Güven
; Niğde Ömer Halisdemir University Faculty of Medicine, Department of Biophysics, Niğde, Turkey
Zehra Tuğba Murathan
; Malatya Turgut Özal University, Battalgazi Vocational School, Battalgazi, Turkey
Nurcan Erbil
; Ardahan University Faculty of Health Sciences, Department of Nursing, Ardahan, Turkey
Deniz Yıldırım
; Çukurova University Faculty of Ceyhan Engineering, Department of Chemical Engineering, Ceyhan, Turkey
Mehmet Büyükleyla
; Ardahan University, Ardahan Vocational School of Health Services, Ardahan, Turkey
Şakire Karadaş
; Kahramanmaraş Sütçü İmam University Faculty of Science and Letters, Department of Biology, Kahramanmaraş, Turkey
Rima Çelik
; Kilis 7 Aralık University Faculty of Science and Letters, Department of Molecular Biology and Genetics, Kilis, Turkey
Eyyüp Rencüzoğulları
; Adıyaman University Faculty of Science and Letters, Department of Biology, Adıyaman, Turkey
Abstract
The aim of this study was to compare the biological activities of ethanolic propolis extracts of Apis mellifera caucasica obtained from Ardahan and Erzurum provinces of Turkey. Samples were tested for antioxidant, anticytotoxic, anticarcinogenic, antibacterial, and antifungal potentials using different techniques. Propolis samples from the two provinces had different mineral and organic compositions related to their geographical origin. The ferric reducing antioxidant power (FRAP) test showed superiority of Ardahan propolis over the Erzurum. Regardless of origin and the presence of mitomycin C in the culture medium, propolis enhanced human peripheral lymphocyte viability, which depended on the duration and propolis concentration. Antiperoxidative activity on MCF-7 breast cancer cells was concentrationdependent. Erzurum propolis showed the highest anticarcinogenic activity at the concentrations of 62.5 μg/mL and 125 μg/ mL, which dropped at higher concentrations. All propolis samples also showed antibacterial activity against the tested human pathogens similar to ampicillin and penicillin controls, except for Pseudomonas aeruginosa. However, they did not exert any antifungal activity against Candida albicans and Yarrowia lipolytica. In conclusion, propolis samples from both provinces showed promising biological activities, but further research should focus on finding the right concentrations for optimal effect and include the cell necrosis pathway to get a better idea of the anticarcinogenic effects.
Keywords
anticarcinogen; antimicrobial; biological activity; mineral; mitomycin C; organic composition
Hrčak ID:
253767
URI
Publication date:
16.3.2021.
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