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Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling?

Nikolina Prtenjaca orcid id
Marin Dominovic
Josip Peradinovic
Rozalija Šajn
Andrea Markovinovic orcid id
Ivana Munitic orcid id ; University of Rijeka

Puni tekst: engleski pdf 730 Kb

str. 23-34

preuzimanja: 223



Mutations in optineurin have been linked to amyotrophic lateral sclerosis (ALS) a decade ago, but its exact role in the neurodegenerative process is still unclear. As a lysine 63 (K63) and methionine (M1) poly-ubiquitin binding protein, optineurin has been reported to act as an adaptor in inflammatory signaling pathways mediated via nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and interferon regulatory factor 3 (IRF3), as well as in membrane-associated trafficking events including autophagy, maintenance of the Golgi apparatus, and exocytosis. Other studies have demonstrated its role in other processes such as regulation of mitosis, transcription, necroptosis and apoptosis. However, many of the reported effects in cell models have been proven difficult to reproduce in optineurin animal models, demonstrating the challenges of extrapolation between model systems. Knowing that multifunctional proteins present a “nightmare” for researchers, to help navigating through this field, we address the most common controversies, open questions, and artefacts related to optineurin and its role in pathogenesis of ALS and other neurodegenerative diseases.

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