Acta clinica Croatica, Vol. 60. No. 1., 2021.
Pregledni rad
https://doi.org/10.20471/acc.2021.60.01.16
Admission Cardiac Troponins Predict Hospital Mortality in Type a Acute Aortic Dissection: a Meta-Analysis of Adjusted Risk Estimates
Mislav Vrsalović
; University of Zagreb, School of Medicine, Zagreb, Croatia; Department of Cardiology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Ana Vrsalović Presečki
; Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia
Sažetak
Acute aortic dissection (AAD) is a serious medical emergency that requires early
diagnosis and rapid treatment. Whether cardiac troponin could be an independent prognostic marker
in patients with type A AAD is still unknown. We systematically searched Medline and Scopus to
identify all observational cohort studies published before January 2020 that compared outcome (inhospital
mortality) in patients with type A AAD with and without troponin elevation on admission.
Four studies with 412 patients were included in final analysis (median age 59 years, 65% of males). A
total of 124 (30%) patients died during in-hospital stay, and 73% underwent surgery. Elevated troponins
(39.6% of patients) were associated with an increased risk of short-term mortality (adjusted odds
ratio 1.26; 95% confidence interval 1.08-1.47), with low heterogeneity among studies (I2=29.81%).
Elevated troponins on admission are independently associated with increased in-hospital mortality in
type A AAD.
Ključne riječi
Troponin; Aortic dissection; Mortality; Meta-analysis
Hrčak ID:
259902
URI
Datum izdavanja:
1.3.2021.
Posjeta: 1.863 *