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ADMET and DMPK, Vol. 10 No. 2, 2022.

Original scientific paper

https://doi.org/10.5599/admet.1179

Synthesis and diverse biological activity profile of triethyl-ammonium isatin-3-hydrazones

Andrei Bogdanov ; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Olga Tsivileva ; Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences, Saratov 410049, Russian Federation
Alexandra Voloshina ; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Anna Lyubina ; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Syumbelya Amerhanova ; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Ekaterina Burtceva ; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Sergey Bukharov ; Kazan National Research Technological University, Kazan 420015, Russian Federation
Alexander Samorodov ; Bashkir State Medical University, Ufa 450000, Russian Federation
Valentin Pavlov ; Bashkir State Medical University, Ufa 450000, Russian Federation

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Abstract

A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR- and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo- and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time.

Keywords

isatin; hemostasis; phytopathogens, antibacterial and antifungal activities

Hrčak ID:

273565

URI

https://hrcak.srce.hr/273565

Publication date:

4.3.2022.

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