Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2021.62.44 6
Diagnostic accuracy, sensitivity, and specificity of CT pulmonary artery to aorta diameter ratio in screening for pulmonary hypertension in end-stage COPD patients
Kristina Gašparović
orcid.org/0000-0002-1191-4831
; Department of Cardiovascular Diseases, University Hospital Center Zagreb, Zagreb, Croatia
Gordana Pavliša
; Department of Respiratory Medicine, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Maja Hrabak Paar
; Department of Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Marija Brestovac
; Department of Cardiovascular Diseases, University Hospital Center Zagreb, Zagreb, Croatia
Martina Lovrić Benčić
; Department of Cardiovascular Diseases, University Hospital Center Zagreb, Zagreb, Croatia
Jadranka Šeparović Hanževački
; Department of Cardiovascular Diseases, University Hospital Center Zagreb, Zagreb, Croatia
Davor Miličić
; Department of Cardiovascular Diseases, University Hospital Center Zagreb, Zagreb, Croatia
Miroslav Samaržija
; Department of Respiratory Medicine, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Josip Juras
; Department of Obstetrics and Gynecology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Sažetak
Aim To determine the diagnostic accuracy of pulmonary
artery to aorta ratio in screening for pulmonary hyperten
-
sion in advanced chronic obstructive pulmonary disease
(COPD) patients.
Methods A prospective, diagnostic study was conducted
in University Hospital Center Zagreb between January 2015
and March 2018. The study enrolled 100 patients who con
-
secutively underwent chest computed tomography (CT),
echocardiographic exam, and right heart catheterization.
Two independent observers measured pulmonary artery
and ascending aorta diameters. The correlation between
the ratio and mean pulmonary artery pressure, measured
invasively, was assessed. Patients with echocardiographic
signs of moderate systolic or diastolic left ventricular dys
-
function were excluded (n
=44).
Results Sixty-six patients (55.5% men), with a median
age of 61, were identified. Median forced expiratory vol
-
ume during the first second (FEV1) was 34
±12, FEV1/
forced vital capacity <0.70. Patients with and without pul
-
monary hypertension had pulmonary artery diameter of
36
±7 mm and 27
±4.6 mm, respectively (
P
<0.001). Me
-
dian pulmonary artery/aorta (PA/A) ratios for patients with
and without pulmonary hypertension were 1.05 and 0.81,
respectively (
P
<0.001). PA/A ratio above 0.95 was an in
-
dependent predictor of pulmonary hypertension with a
specificity of 100% and a sensitivity of 74.51% (area under
the curve
=0.882; standard error
=0.041;
P
<0.001).
Conclusion PA/A ratio as measured on chest CT images
can be used as a screening tool instead of echocardiog
-
raphy
Ključne riječi
Hrčak ID:
278464
URI
Datum izdavanja:
21.10.2021.
Posjeta: 689 *