Izvorni znanstveni članak
https://doi.org/10.2478/aiht-2022-73-3658
Antioxidative, cytotoxic, and antibacterial properties of selfassembled glycine-histidine-based dipeptides with or without silver nanoparticles in bio-inspired film
Merve Eylul Kiymaci
orcid.org/0000-0001-5343-1064
; University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Ankara, Turkey
Hakan Erdoğan
orcid.org/0000-0002-7791-7445
; University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey
Merve Bacanlı
orcid.org/0000-0001-8757-0572
; University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey
Sažetak
Recent years have seen much attention being given to self-assembly of dipeptide-based structures, especially to self-regulation of dipeptide structures with different amino acid sequences. In this study we investigated the effects of varying solvent environments on the selfassembly of glycine-histidine (Gly-His) dipeptide structures. First we determined the morphological properties of Gly-His films formed in different solvent environments with scanning electron microscopy and then structural properties with Fourier-transform infrared (FTIR) spectroscopy. In addition, we studied the effects of Gly-His films on silver nanoparticle (AgNP) formation and the antioxidant and cytotoxic properties of AgNPs obtained in this way. We also, assessed antibacterial activities of Gly-His films against Gram-negative Escherichia coli and Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus. Silver nanoparticle-decorated Gly-His films were not significantly cytotoxic at concentrations below 2 mg/mL but had antibacterial activity. We therefore believe that AgNP-decorated Gly-His films at concentrations below 2 mg/mL can be used safely against bacteria.
Ključne riječi
Ag; antibacterial surface; Escherichia coli; Pseudomonas aeruginosa; Staphylococcus aureus; toxicity
Hrčak ID:
279735
URI
Datum izdavanja:
27.6.2022.
Posjeta: 1.292 *