Izvorni znanstveni članak
https://doi.org/10.20471/acc.2024.63.03-04.26
Etiology of Urinary Tract Infections in Neonates and Bacterial Resistance in Croatia
Ana-Meyra Potkonjak
; Department of Obstetrics and Gynecology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ivana Terzić
; Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia
Mario Lovrić
; Center of Bioanthropology, Institute of Anthropological Research, Zagreb, Croatia
Vesna Gall
; Department of Obstetrics and Gynecology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Hrvojka Soljačić Vraneš
; Department of Obstetrics and Gynecology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Danko Milošević
; Department of Pediatrics, Zabok General Hospital and Croatian Veterans Hospital, Bračak, Croatian Academy of Medical Sciences, Zagreb, Croatia
Neven Tučkar
; Department of Obstetrics and Gynecology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Goran Vujić
; Department of Obstetrics and Gynecology, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia
Vesna Košec
; Department of Obstetrics and Gynecology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ana Budimir
; Department of Typing and Monitoring the Causes of Nosocomial Infections, Zagreb University Hospital Center, Zagreb, Croatia
Boris Filipović-Grčić
; Department of Pediatrics, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia
*
* Dopisni autor.
Sažetak
Urinary tract infection (UTI) occurs in approximately 15% of full-term neonates
and 8% of those born before 37 weeks of gestation. Severe UTI can lead to sepsis or long-term complications
such as renal scarring and hypertension. Given the rising concern of bacterial resistance to
antibiotics, this research aimed to examine the epidemiology of neonatal UTI, most common antibiotic
prescription patterns, as well as resistance of the causative agents in Croatia. This retrospective
multicenter analysis was focused on neonates born in 2005 and 2015. Of the 103 bacterial UTI cases,
78.6% affected term neonates. Male neonates constituted 62.1% of the study population. Eutrophic
neonates accounted for 87.4%, and hospital-acquired infections were prevalent in 47.6% of cases. The
main causative pathogens were Escherichia coli (60.2%) and Klebsiella pneumoniae (28.2%). Most commonly
prescribed empirical antibiotics included ceftriaxone (31.1%) and the ampicillin-gentamicin
combination (10.7%). In 2005, 72.7% of isolates were sensitive to empirical therapy. In 2015, sensitivity
to empirical antibiotic therapy was observed in 75.6% of cases. In this study, Escherichia coli
frequently exhibited antibiotic resistance to ampicillin, amoxicillin, trimethoprim-sulfamethoxazole,
and gentamicin. For UTIs attributed to Klebsiella pneumoniae, the prevailing bacterial resistance was
observed against gentamicin, ceftibuten, ampicillin, cefazolin, and piperacillin. The predominance of
Escherichia coli as the most common pathogen causing UTI was consistent with global trends. Founded
on continuous differences in bacterial resistance, this study can serve as a basis for comprehending local resistance patterns of pathogens causing neonatal UTI, highlighting the need of additional prospective
research.
Ključne riječi
Urinary tract infections; Neonates; Antibiotic resistance, escherichia coli; Klebsiella pneumoniae; Antibiotic therapy
Hrčak ID:
333282
URI
Datum izdavanja:
31.12.2024.
Posjeta: 831 *