Izvorni znanstveni članak
https://doi.org/10.18054/pb.v126i3-4.34078
Epithelial sentinel: Selective expression of CD123, the α chain of the IL-3 receptor, on distinct digestive and respiratory surfaces
Suzana Popović
; University of Kragujevac, Serbia, Faculty of Medical Sciences, Centre for Molecular Medicine and Stem Cell Research, Kragujevac, Serbia
Dejan Baskić
; University of Kragujevac, Serbia, Faculty of Medical Sciences, Centre for Molecular Medicine and Stem Cell Research, Kragujevac, Serbia; Institute of Public Health Kragujevac, Kragujevac, Serbia
Danijela Todorović
; University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Genetics, Kragujevac, Serbia
Predrag Djurdjević
; University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Internal Medicine, Kragujevac, Serbia; University Clinical Centre Kragujevac, Clinic for Hematology, Kragujevac, Serbia
Maja Sazdanović
; University of Kragujevac, Faculty of Medical Sciences, Department of Histology and Embryology
*
Sanja Matić
; University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, Serbia
Tijana Marković
orcid.org/0009-0004-7726-1716
; University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, Serbia
Predrag Sazdanović
; University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Anatomy, Kragujevac, Serbia; University Clinical Centre Kragujevac, Gynecology and Obstetrics Clinic, Kragujevac, Serbia
Slobodanka Mitrović
; University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Pathology, Kragujevac, Serbia; University Clinical Centre Kragujevac, Department of Pathology, Kragujevac, Serbia
* Dopisni autor.
Sažetak
Background and purpose: Epithelial tissue, functioning as a protective barrier, has mechanisms to recognize an array of external disturbances and threats and to send signals to the immune system. Here we report the uncovering of the selective expression of CD123 on epithelial cells lining distinct surfaces of the digestive system and lungs.
Materials and methods: The expression level of CD123, the α chain of the heterodimeric receptor for Interleukin-3, was detected by immunohistochemical staining.
Results: We found high expression of CD123 on pancreas duct cells, intrahepatic bile ducts epithelial cells, and alveolar epithelium, but not on hepatocytes, gastric mucosa, duodenal, and colon mucosa. The CD123 expression on carcinoma specimens showed the same pattern as the tissue of origin.
Conclusions: We postulated that CD123 expression is characteristic of the epithelium of normally germ-free compartments that is, in steady state, quiescent, in terms of low turnover and low cytokine production. Upon infection and subsequent inflammation, IL-3 produced by activated immune cells may contribute to the restoration of the epithelial barrier by enhancing epithelial cell proliferation and cytokine production.
Ključne riječi
CD123; epithelial cells; digestive tract; lungs
Hrčak ID:
336103
URI
Datum izdavanja:
11.9.2025.
Posjeta: 293 *