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Medica Jadertina, Vol. 55 No. Suplement 1, 2025.

Sažetak sa skupa

Prognostic value of lymphocyte to monocyte ratio and fibrinogen in oropharyngeal squamous cell carcinoma

Stela Marković orcid id orcid.org/0000-0003-2149-2422 ; OB Virovitica, Ulica Ljudevita Gaja 21, 33000 Virovitica, Hrvatska
Josip Vrančić ; OB Varaždin, Ul. Ivana Meštrovića 1, 42000 Varaždin, Hrvatska
Drago Prgomet ; KBC Zagreb, Kišpatićeva 12, 10000 Zagreb, Hrvatska; Medicinski fakultet Sveučilišta u Zagrebu, 10000 Zagreb, Hrvatska
Lovro Matoc ; KBC Zagreb, Kišpatićeva 12, 10000 Zagreb, Hrvatska
Dinko Leović ; KBC Zagreb, Kišpatićeva 12, 10000 Zagreb, Hrvatska; Sveučilište J. J. Strossmayera u Osijeku, Medicinski fakultet, 31000 Osijek, Hrvatska; Sveučilište J.J. Strossmayera u Osijeku, Fakultet za dentalnu medicinu i zdravstvo, 31000 Osijek, Hrvatska

Puni tekst: engleski pdf 186 Kb

str. 64-64

preuzimanja: 61

citiraj

Sažetak

Background: TNM stage and p16 status are the key prognostic factors in oropharyngeal squamous cell
carcinoma (OPSCC) but may not fully explain the outcome variability. Inflammatory biomarkers such as
lymphocyte-to-monocyte ratio (LMR) and fibrinogen have shown prognostic potential but lack clinical
integration. Methods: We retrospectively analyzed 113 patients with histologically confirmed OPSCC (2011
–2024). Associations between pre-treatment LMR, fibrinogen, and survival outcomes (overall survival (OS),
event-free survival (EFS)) were assessed. ROC analysis defined cutoffs. A prognostic nomogram was
developed using multivariable Cox regression. Results: Multivariate analysis identified initial treatment
modality, LMR, and fibrinogen as independent predictors of OS. LMR >2.121 was associated with better OS
(HR = 0.38; p < 0.001). while fibrinogen >4.2 g/L predicted worse survival ((HR = 4.43; p < 0.001). The
nomogram showed good discrimination (C-index = 0.74). Conclusions: Incorporating LMR and fibrinogen
into prognostic assessment may improve risk stratification beyond conventional staging in OPSCC. These
accessible biomarkers could help guide treatment intensity and follow-up strategies

Ključne riječi

head and neck cancer; oropharyngeal cancer; lymphocyte-to-monocyte ratio (LMR); fibrinogen; inflammation

Hrčak ID:

336376

URI

https://hrcak.srce.hr/336376

Datum izdavanja:

10.11.2025.

Posjeta: 136 *