Pregledni rad
https://doi.org/10.26332/nw6a5y85
Management and Perspectives of Pregnancies in Solid Organ Transplant Recipients
Žana Stanić
orcid.org/0000-0002-9474-9105
; Faculty of Dental Medicine and Health Osijek. University of Josip Juraj Strossmayer – Osijek, Croatia; Institute of Gynecology, Obstetrics and Minimally Invasive Gynecological Surgery, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University in Osijek, Croatia; General Hospital Zabok and Croatian Veterans Hospital, Croatia
*
Rajko Fureš
; Faculty of Dental Medicine and Health Osijek. University of Josip Juraj Strossmayer – Osijek, Croatia; Institute of Gynecology, Obstetrics and Minimally Invasive Gynecological Surgery, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University in Osijek, Croatia; General Hospital Zabok and Croatian Veterans Hospital, Croatia; Faculty of Health Studies, University of Rijeka, Croatia; Croatian Society of Pelviperineology, Zabok, Croatia
Milvija Plazibat
; Faculty of Dental Medicine and Health Osijek, University of Josip Juraj Strossmayer Osijek, Croatia; General Hospital Zabok and Croatian Veterans Hospital, Croatia; Department of Paediatrics, General Hospital Zabok and Croatian Veterans Hospital, Croatia
Katarina Svažić
; Faculty of Dental Medicine and Health Osijek, University of Josip Juraj Strossmayer Osijek, Croatia; Institute of Gynecology, Obstetrics and Minimally Invasive Gynecological Surgery, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University Osijek, Croatia; General Hospital Zabok and Croatian Veterans Hospital, Croatia
* Dopisni autor.
Sažetak
Advances in immunosuppressant drugs and surgical techniques enabled pregnancies in numerous women who suffer of end-stage organ disfunction worldwide. Better tolerance to allogenic grafts, and ameliorated risk of drug toxicity created a possibility of both successful reproduction and preservation of a long-time function of a transplanted organ. 75%of pregnancies in transplant patients are registered among renal transplant recipients, followed by liver and heart transplant, all of them connected into a group of solid organ transplants (SOT). Increasing number of pregnancies emerge also from the group of patients with combined simultaneous renal-pancreatic transplant (RPT), due to treatment of an end-stage organ disfunction of diabetes mellitus Type 1, and a lung transplant, due to terminal stage of cystic fibrosis. All transplant recipints have an increased risk of miscarriage, preterm birth and fetal malformations. Renal and RPT recipients are in enhanced risk of hypertensive disorders and preeclampsia. All the immunosuppressant drugs pass the fetoplacental barrier, and pose a certain risk for embryonal and fetal development. There is no absolute safe immunosuppressant. Pregnancies of women with solid organ transplantations are high-risk pregnancies, with certain peculiarities for each of different transplanted organs. These pregnancies have to be closly monitored and supervised by multidisciplinary teams consisted of transplant medicine specialists, surgeons, maternal-fetal medicine subspecialists and neonatologists. Furthermore, SOT open a new winodow of ethical concerns due to reduced maternal lifespan and different moral dilemmas connected with support of their ofspring.
Ključne riječi
solid organ transplant, pregnancy, immunosupressant drugs, allogenic grafts
Hrčak ID:
342732
URI
Datum izdavanja:
29.12.2025.
Posjeta: 304 *