Izvorni znanstveni članak

https://doi.org/10.5562/cca4203

A Step-by-Step Synthesis of Pyridine-Benzimidazole-Chalcone Hybrids: Anticancer and Antimycobacterial Activity

Nagesh V. Edake ; Organic Chemistry Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur–413255, Maharashtra, India
Samadhan A. Shenmare ; Organic Chemistry Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur–413255, Maharashtra, India
Pravin S. Bhale ; Department of Chemistry, Yeshwantrao Chavan Mahavidyalaya-Tuljapur–413601, Maharashtra, India
Mahesh G. Hublikar ; Organic Chemistry Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur–413255, Maharashtra, India
Dattatraya G. Raut ; Vishwasrao Naik Arts, Commerce and Baba Naik Science Mahavidyalaya, Shirala Dist Sangli
Ganesh B. Pandhare ; Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur–413255, Maharashtra, India
Nikita S. Pendpale ; Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur–413255, Maharashtra, India
Sadanand N. Shringare orcid.org/0000-0003-2217-5648 ; Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur–413255, Maharashtra, India *
Raghunath B. Bhosale ; Organic Chemistry Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur–413255, Maharashtra, India *

* Dopisni autor.

Prilozi: cca4203_supplement.pdf

Sažetak

A novel series of hybrid compounds N-(pyridine-2-yl) acetamide-substituted benzimidazole chalcones (9a–j) were synthesised in good yield. The structure of the compounds was confirmed by spectroscopic techniques. All the compounds were tested for their in vitro anticancer (MCF 7 cell line) and anti- Mycobacterial activity against M. tuberculosis (Vaccine strain, H37 RV strain); ATCC No–27294. Most of the compounds 9a, 9d, 9e, 9f, 9g, 9h, 9i, and 9j exhibited appreciable activity with GI50 ranging from 1.0 to 10.0 µM against the MCF 7 cell line. On the other hand, compound 9h in the series exhibited substantial activity against the bacterial strain with a MIC valve of 12.5 μg mL–1. Evaluation of the anticancer and anti-Mycobacterial activity showed that the compound (9h), being di-substituted with flouro group at the chalcone ring of the benzimidazole-chalcone skeleton, participate in improving the potency.

Ključne riječi

anticancer; GI50; anti-mycobacterial; benzimidazole; alamar blue dye

Hrčak ID:

342923

URI

https://hrcak.srce.hr/342923

Datum izdavanja:

31.12.2025.

Posjeta: 501 *