Izvorni znanstveni članak

https://doi.org/10.20471/acc.2025.64.03.06

HLA II Alleles and Susceptibility to Multiple Sclerosis in Croatia

Sandra Jagnjić ; Department of Immunohematology, Croatian Institute of Transfusion Medicine (CITM), Zagreb, Croatia *
Jasna Bingulac-Popović ; Department of Molecular Diagnostics, CITM, Zagreb, Croatia
Vesna Đogić ; Department of Molecular Diagnostics, CITM, Zagreb, Croatia
Anton Vladić ; University Hospital “Sveti Duh”, University Department of Neurology, Zagreb, Croatia; Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Department of Neurology and Neurosurgery, Osijek, Croatia
Katarina Štingl Janković ; Tissue Typing Center, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia
Zrinka Kruhonja Galić ; Department of Immunohematology, Croatian Institute of Transfusion Medicine (CITM), Zagreb, Croatia
Ana Hećimović ; Department of Reagents Production, CITM, Zagreb, Croati
Irena Jukić ; edical Department, CITM, Zagreb, Croatia; Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Department of Microbiology, Parasitology and Clinical Laboratory Diagnostics, Osijek, Croatia

* Dopisni autor.

Sažetak

The aim of the present case-control study was to evaluate associations between
HLA-DRB1 and HLA-DQB1 alleles, genotypes and haplotypes to multiple sclerosis (MS) susceptibility
in the Croatian population. HLA-DRB1 and HLA-DQB1 genotyping was performed on
a group of 173 relapsing-remitting MS patients and 205 healthy voluntary blood donors without a
history of demyelization diseases. HLA class II genes were analyzed using the PCR-SSP method
(CareDx AB, Sweden). Our results demonstrated a positive association for alleles HLA-DRB1*15:01
(odds ratio [OR]=3.17; P corrected [Pc] = 0.004), -DQB1*06:02 (OR = 2.87; Pc = 0.002) and haplotype
HLA-DRB1*15:01~DQB1*06:02 (OR = 2.75; Pc = 0.001) that withstood correction for multiple comparisons.
Risk factors identified as significantly predisposing for MS, but only prior to Bonferroni correction
were: HLA-DQB1*03:02 allele (P = 0.016), HLA-DRB1*01:01/*13:01 (P = 0.033), -DRB1*07:01/*15:01
(P = 0.045) and -DQB1*03:02/*06:02 genotypes (P = 0.031) and HLA-DRB1*04:02~DQB1*03:02
(P = 0.034) and HLA-DRB1*07:01~DQB1*03:03 haplotypes (P = 0.019). A protective effect against
MS was shown by alleles HLA-DRB1*11:01 (P = 0.004) and -DQB1*03:01 (P = 0.014) and haplotype
HLA-DRB1*11:01~DQB1*03:01 (P = 0.013), but also only before the Bonferroni correction. In conclusion,
our results confirm that HLA class II alleles and their interactions modulate MS susceptibility and
protection in the Croatian population.

Ključne riječi

Multiple sclerosis; HLA class II alleles; Susceptibility; Protection

Hrčak ID:

342932

URI

https://hrcak.srce.hr/342932

Datum izdavanja:

30.9.2025.

Podaci na drugim jezicima: hrvatski

Posjeta: 378 *