Acta clinica Croatica, Vol. 64. No. 3, 2025.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2025.64.03.09
COPD, Age, LDH, Troponin, D-Dimer, and CRP/Albumin Ratio: A new Prognostic Model for COVID-19
Elif Yıldırım Ayaz
orcid.org/0000-0002-2404-8784
; University of Health Sciences, Sultan 2. Abdülhamid Han Training and Research Hospital, Üsküdar, İstanbul, Turkey
*
Mustafa Kaplan
; University of Health Sciences, Sultan 2. Abdülhamid Han Training and Research Hospital, Üsküdar, İstanbul, Turkey
Ahmet Said Bulut
; Sancaktepe Şehit Prof. Dr. İlhan Varanak Training and Research Hospital, Emek mah, Sancaktepe, İstanbul, Turkey
Handan Ankaralı
; Istanbul Medeniyet University, Egitim mah, Kadıkoy, Istanbul, Turkey
Zafer Ünsal Coşkun
; University of Health Sciences, Sultan 2. Abdülhamid Han Training and Research Hospital, Üsküdar, İstanbul, Turkey
Gökhan Uygun
; Istanbul Medeniyet University, Prof. Dr. Süleyman Yalçın City Hospital, Kadıköy, İstanbul, Turkey
Özge Telci Çaklılı
; Istanbul Faculty of Medicine, Fatih, Istanbul, Turkey
Mehmet Uzunlulu
; Istanbul Medeniyet University, Prof. Dr. Süleyman Yalçın City Hospital, Kadıköy, İstanbul, Turkey
Haluk Vahaboğlu
; Istanbul Medeniyet University, Prof. Dr. Süleyman Yalçın City Hospital, Kadıköy, İstanbul, Turkey
Sacit İçten
; Istanbul Medeniyet University, Prof. Dr. Süleyman Yalçın City Hospital, Kadıköy, İstanbul, Turkey
Ali Rıza Odabaş
; University of Health Sciences, Sultan 2. Abdülhamid Han Training and Research Hospital, Üsküdar, İstanbul, Turkey
* Dopisni autor.
Sažetak
The aim of this study was to determine the relationship between demographic characteristics,
initial laboratory data and comorbidities with prognosis in inpatients followed up for coronavirus
disease 2019 (COVID-19) and to create a new model for predicting mortality risk. In this multicenter,
retrospective cohort study, patient demographic and clinical data were recorded at the first patient
admission to the hospital. The primary outcome was to evaluate the relationship of demographic characteristics,
laboratory parameters and comorbidities with mortality. Parameters found to be associated
with mortality in univariate analyses were also evaluated with multivariate analyses and a final model was
established. In the final model, the presence of chronic obstructive pulmonary disease (COPD) (OR:
3.177, 95% CI: 1.574-6.413), age (OR: 1.056, 95%CI: 1.034-1.078), lactate dehydrogenase (LDH)
(OR: 1.002, 95%CI: 1.001-1.003), troponin (OR: 1.052, 95% CI: 1.007-1.099), D-dimer (OR: 1.012,
95%CI: 1.002-1.021), and C-reactive protein (CRP)/albumin ratio (OR: 1.278, 95%CI: 1.145-1.427)
were found to be associated with mortality. The model accurately predicted mortality with a sensitivity
of 82.6% and specificity of 77.7%. COPD, age, LDH, troponin, D-dimer, and CRP/albumin ratio were
determined as factors associated with mortality. Assessment of these parameters at the time of admission
of inpatients, classifying patients as high risk, and adopting early and appropriate treatment approaches
may help in the management of patients.
Ključne riječi
COVID-19; Mortality; Prognosis; Chronic obstructive pulmonary disease; Lactate dehydrogenase
Hrčak ID:
342935
URI
Datum izdavanja:
30.9.2025.
Posjeta: 369 *