Acta clinica Croatica, Vol. 64. No. 3, 2025.
Original scientific paper
https://doi.org/10.20471/acc.2025.64.03.15
Evaluation of Serum Homocysteine and Asymmetric Dimethylarginine Levels in Patients with Autoimmune Thyroid Disease
Esra Paydaş Hataysal
; Department of Biochemistry, Goztepe Prof. Dr. Suleyman Yalçın City Hospital, İstanbul, Turkey
Muslu Kazım Körez
; Department of Biostatistics, Selcuk University Faculty of Medicine, Konya, Turkey
Fatma Sengul
orcid.org/0000-0002-7097-6266
; Department of Biochemistry, Adiyaman University Faculty of Pharmacy, Adiyaman, Turkey
*
Hüsamettin Vatansev
; Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey
Emel Şahin
; Department of Biochemistry, Osmaniye State Hospital, Osmaniye, Turkey
Cem Onur Kıraç
; Department of Endocrinology and Metabolism, Necip Fazil City Hospital, Kahramanmaraş, Turkey
Levent Kebapçılar
; Department of Endocrinology and Metabolism, Medova Hospital, Konya, Turkey
Süleyman Hilmi İpekci
; Department of Endocrinology and Metabolism, Atlas University Faculty of Medicine, İstanbul, Turkey;
Sedat Abuşoğlu
; Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey
Ali Ünlü
; Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey
* Corresponding author.
Abstract
Autoimmune thyroid diseases (AITD) may lead to increased cardiovascular risk;
however, the underlying mechanism for this is unclear. The aim of our study was to investigate serum
asymmetric dimethylarginine (ADMA), vitamin B12, folic acid and homocysteine (HCY) levels in patients
with and without AITD. A total of 180 individuals were enrolled in this study, encompassing 45
patients with Hashimoto’s Thyroiditis (HT), 45 patients with Graves’ disease (GD), 45 individuals with
multinodular goiter (MNG) and 45 healthy controls who were admitted to Selçuk University Medical
Faculty’s Department of Endocrinology. All statistical analyses were conducted using the R Statistical
Software (version 4.2.1). We found increased levels of HCY and ADMA, and decreased levels of folic
acid in AITD compared to the control group (P = 0.021, P = 0.04 and P = 0.017, respectively). Vitamin
B12 levels were similar between groups. HCY was negatively correlated with vitamin B12 and folic acid
(r = -0.028, P = 0.002 and r = -0.368, P < 0.001, respectively). Our study revealed that a rise in ADMA and
HCY levels in patients with AITD can provide insight into how AITD may contribute to endothelial
dysfunction and cardiovascular risks.
Keywords
Hashimoto disease; Graves’ disease; Asymmetric dimethylarginine; Homocysteine
Hrčak ID:
342941
URI
Publication date:
30.9.2025.
Visits: 445 *