Izvorni znanstveni članak
https://doi.org/10.5599/jese.3061
Sustainable electrochemical sensor for green analysis of diaveridine HCl and sulphaquinoxaline Na in food and pharmaceutical samples
Mai Abd El-Aziz
; Pharmaceutical Analytical Chemistry Department, Misr University for Science & Technology, College of Pharmaceutical Sciences and Drug Manufacturing, 6th of October City, Giza, 12566, Egypt
Hadeer F. Manie
orcid.org/0000-0001-6818-6591
; Pharmaceutical Analytical Chemistry Department, Egyptian Drug Authority, Giza, Egypt
Heba Elbalkiny
; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Art, Egypt
Marwa I. Helmy
; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan,11795, Egypt and Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, 12566, Cairo, Egypt
Dalia Mohamed
; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan,11795, Egypt
Lobna M. Abd El Halim
; Pharmaceutical Analytical Chemistry Department, Egyptian Drug Authority, Giza, Egypt
*
* Dopisni autor.
Sažetak
In veterinary medicine, diaveridine hydrochloride (DVH) is a common antiprotozoal medication, and sulfaquinoxaline sodium (SQL) is an antibacterial used to treat intestinal infections, including coccidia. They are added to poultry feed as anticoccidials and their residues might be retained in chicken tissues. Therefore, there is an urgent need for fast determination of the lowest possible DVH and SQL concentrations to guarantee food safety. This study used cyclic voltammetry and square-wave voltammetry. A sensitive electrochemical sensor was developed for fast and selective simultaneous determination of DVH and SQL in drug substances, chicken meat and pharmaceutical formulations. Copper oxide nanoparticles (CuO NPs) served as the foundation for the created tailored sensor. An excellent linearity and high correlation (0.9995 for DVH and 0.9994 for SQL) were identified in the linear responses produced for DVH and SQL utilizing CuO NPs at carbon paste electrode (CPE), which were over the range of 15.00 nM to 120.00 mM for DVH and 90.00 nM to 100.00 mM for SQL. CuO NPs/CPE was used to determine residues in chicken meat as real samples, achieving outstanding recoveries due to its high sensitivity, superior repeatability, and wide linear range. The study also emphasizes the comprehensive environmental impact assessment facilitated by the synergistic application of Modified Complex GAPI (Complex MoGAPI) and AGREE tools.
Ključne riječi
Coccidiosis treatment drugs; voltammetry techniques; modified electrodes; copper oxide nanoparticles; food safety; greenness assessment
Hrčak ID:
344846
URI
Datum izdavanja:
13.12.2025.
Posjeta: 367 *