Other
https://doi.org/10.26332/dpcz2937
Investigating the Roles of Metabolic Syndrome and Inflammation as Prognostic Factors in Colorectal Cancer: A Retrospective Study
Andreja Bartulić
; Faculty of Medicine Osijek, J. J. Strossmayer University Osijek, Osijek, Croatia; Department of Gastroenterology, Clinic of Internal Medicine, Clinical Hospital Osijek, Osijek, Croatia
Romana Marušić
; Faculty of Medicine Osijek, J. J. Strossmayer University Osijek, Osijek, Croatia; Department of Internal medicine, National Memorial Hospital Dr Juraj Njavro, Vukovar, Vukovar, Croatia
Maja Gradinjan Centner
; Department of Endocrinology, Clinic of Internal Medicine, Clinical Hospital Osijek, Osijek, Croatia
Hrvoje Centner
; Faculty of Medicine Osijek, J. J. Strossmayer University Osijek, Osijek, Croatia
Ema Schönberger
; Faculty of Medicine Osijek, J. J. Strossmayer University Osijek, Osijek, Croatia; Department of Endocrinology, Clinic of Internal Medicine, Clinical Hospital Osijek, Osijek, Croatia
Daria Sladić Rimac
; Department of Endocrinology, Clinic of Internal Medicine, Clinical Hospital Osijek, Osijek, Croatia; Faculty of Dental Medicine and Health Osijek, Department of Nursing and Palliative Medicine, University J. J. Strossmayer, Osijek, Croatia
Darko Dukić
orcid.org/0000-0002-9131-232X
; Department of Physics, J. J. Strosmayer University Osijek, Osijek, Croatia
Gordana Dukić
orcid.org/0000-0002-1166-6807
; Faculty of Humanities and Social Sciences, Department of Information Sciences, J. J. Strossmayer University Osijek, Osijek, Croatia
Josipa Flam
; Faculty of Medicine Osijek, J. J. Strossmayer University Osijek, Osijek, Croatia; Clinic of Radiotherapy and Oncology, Clinical Hospital Center Osijek, Osijek, Croatia
Damir Mihić
; Faculty of Medicine Osijek, J. J. Strossmayer University Osijek, Osijek, Croatia; Intensive Care Unit, Department of Internal Medicine, Clinical Hospital Center, Osijek, Croatia
Jasenka Wagner
orcid.org/0000-0002-1126-7523
; Faculty of Medicine Osijek, J. J. Strossmayer University Osijek, Osijek, Croatia
*
* Corresponding author.
Abstract
Aim: Colorectal cancer (CRC) is a leading cause of cancer-related mortality, and there is an increasing amount of evidence suggesting a link between metabolic syndrome (MetS) and the progression of this disease. MetS-related chronic inflammation, oxidative stress, and insulin resistance may contribute to tumor growth and influence patient survival. This study examined the association between MetS, systemic inflammation, and five-year survival among CRC patients.Methods: A retrospective analysis was conducted on 95 patients treated for CRC at Osijek University Hospital Centre from October 2016 to December 2019. Clinical data, including tumor localization, stage, metabolic parameters, and inflammatory markers (CRP, ESR, and fibrinogen), were collected and analyzed.Results: Among the 95 patients analyzed, 51.6 % were male, with a median age of 66 years, and 48.4 % were female, with a median age of 63 years. No significant associations were found between MetS, BMI, and five-year survival. However, patients with normal ESR values had significantly higher five-year survival rates (p = 0.005). Higher fibrinogen levels were unexpectedly associated with improved survival (p = 0.029), whereas elevated CRP levels showed a non-significant trend toward worse outcomes. Tumor localization and stage did not significantly impact survival rates.Conclusions: These findings emphasize the importance of systemic inflammation in CRC prognosis, suggesting its potential as a prognostic factor independent of MetS. While MetS itself is not directly associated with survival, its pro-inflammatory components may be related.
Keywords: metabolic syndrome; colorectal neoplasms; inflammation; survival
Keywords
metabolic syndrome; colorectal neoplasms; inflammation; survival
Hrčak ID:
345713
URI
Publication date:
18.5.2026.
Visits: 256 *