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https://doi.org/10.20471/acc.2026.65.01.06

Helicobacter Pylori as an Etiologic Factor for Development of Nasal Polyposis in Patients with Extraesophageal Reflux

Andrijana Včeva ; Department of Otorhinolaryngology and Maxillofacial Surgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Otorhinolaryngology, Head and Neck Surgery, Osijek University Hospital Center, Osijek, Croatia
Ivan Abičić ; Department of Otorhinolaryngology and Maxillofacial Surgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Otorhinolaryngology, Head and Neck Surgery, Osijek University Hospital Center, Osijek, Croatia
Tihana Mendeš ; Department of Otorhinolaryngology and Maxillofacial Surgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Otorhinolaryngology, Head and Neck Surgery, Osijek University Hospital Center, Osijek, Croatia *
Martina Smolić ; Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Robert Smolić ; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Pathophysiology and Physiology with Immunology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Aleksandar Včev ; Department of Pathophysiology and Physiology with Immunology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Internal Medicine, Osijek University Hospital Center, Osijek, Croatia
Željko Zubčić ; Department of Otorhinolaryngology and Maxillofacial Surgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Otorhinolaryngology, Head and Neck Surgery, Osijek University Hospital Center, Osijek, Croatia

* Dopisni autor.

Sažetak

The aim of this cross-sectional study was to identify Helicobacter pylori (HP) as an
etiologic factor for the development of nasal polyposis (NP) in patients with extraesophageal
reflux (EER). The study enrolled 35 cases with NP and 30 controls with bullous middle nasal concha (CB) undergoing endoscopic sinus surgery (ESS). All subjects underwent esophagogastroendoscopy with routine antrum and corpus biopsies and filled out two questionnaires on EER and nasal symptoms (NS) prior to ESS. All gastric and nasal biopsy specimens were histopathologically and real time polymerase chain reaction (RT PCR) examined for HP. All subjects, cases and controls, had positive results for HP in gastric mucosa and 33 (50.8%) subjects had EER. The proportion of patients with reported EER was
significantly higher among patients with NP (70.0% vs. 30.0%; χ2-test, p=0.003).
HP was identified in nasal mucosa in 10 (30.3%) patients with NP and all 10 patients
had EER and NS. HP was not detected in any control patient with CB. HP
was not present in healthy nasal mucosa. HP can be detected in nasal mucosa
in about 40% of patients with nasal polyps and EER. HP can be considered as an
etiologic factor in patients with NP and EER although further studies are needed
to evaluate this correlation.

Ključne riječi

Helicobacter pylori; Nasal polyposis; Extraesophageal reflux; Chronic rhinosinusitis

Hrčak ID:

345830

URI

https://hrcak.srce.hr/345830

Datum izdavanja:

27.3.2026.

Podaci na drugim jezicima: hrvatski

Posjeta: 251 *