Recenzija, prikaz
Linear IgA Bullous Dermatosis in Adults and Children: A Narrative Review of Literature on Disease Distribution and Evaluation of Existing Scoring Tools
Alena Yang
; Faculty of Medicine, University of NSW, Sydney, NSW, Australia
Sera Sarsam
; Faculty of Medicine, University of NSW, Sydney, NSW, Australia
Dedee F. Murrell
; Faculty of Medicine, University of NSW, Sydney, NSW, Australia
*
* Dopisni autor.
Sažetak
Linear IgA Bullous Dermatosis (LABD) is a rare autoimmune blistering
disease (AIBD) characterized by linear depositions of IGA antibodies
at the dermo-epidermal junction, resulting in subepithelial vesiculobullous
lesions that affect the skin and mucous membranes. Despite advancements
in the study of AIBDs, significant gaps persist in LABD’s clinical presentation,
treatment, and outcome measures due to the absence of validated, diseasespecific
scoring systems. The purpose of this paper is to identify any differences
in disease distribution between adults and children, and to review
and evaluate existing scoring tool for AIBDs. A literature search was performed
using Embase and PubMed to identify relevant studies and case reports.
According to the literature, adults and children had different cutaneous
distributions of disease, with lesions on the perineum, hands and feet,
and face more frequently reported in children. However, there was inconsistent
data on whether mucous membrane lesions were more frequent in
adults or children. Current scoring systems for AIBDs were also identified,
with several systemic scoring systems existing in the literature that are validated
in scoring AIBD severity. There is currently no literature on scoring
systems specific to LABD, underscoring the need to develop and validate
LABD specific tools to facilitate the development of standardized treatment
guidelines and advance the understanding and management of LABD.
Ključne riječi
Linear IgA bullous dermatoses; chronic bullous disease of childhood; treatment and outcomes; disease severity; scoring system
Hrčak ID:
346945
URI
Datum izdavanja:
26.2.2025.
Posjeta: 0 *