Case report, case study
Diagnostic and Therapeutic Challenges of Cutaneous Lymphoid Hyperplasia in the Facial Region: A Case Report
Loren Serdarević
; School of Medicine, University of Zagreb, Zagreb, Croatia
Ivan Raguž
; School of Medicine, University of Zagreb, Zagreb, Croatia
Ivana Ilić
; School of Medicine, University of Zagreb, Zagreb, Croatia
Snježana Dotlić
; Clinical Department of Pathology and Cytology, University Hospital Centre Zagreb, Zagreb, Croatia
Romana Čeović
; 2Department of Dermatology and Venerology, Zagreb University Hospital Center, Zagreb, Croatia
*
* Corresponding author.
Abstract
Cutaneous lymphoid hyperplasia (CLH) is a benign skin disorder
that clinically and histopathologically mimics cutaneous lymphoma,
making it a diagnostic challenge. CLH can exhibit a predominance of B
cells, T cells, or a combination of both. This report illustrates a case of a
27-year-old male patient with an erythematous plaque on his cheek, initially
histopathologically described as lymphoid hyperplasia of B-immunophenotype.
The lesion recurred years later, necessitating a thorough
diagnostic investigation.
Clonality analysis coupled with imaging led to the exclusion of cutaneous
lymphoma, therefore confirming B-cell CLH as the final diagnosis.
Treatment options were limited by the esthetic demands of the facial region,
as well as the patient’s age, considering the risks of radiotherapy in
younger patients.
Furthermore, the possibility of progression to cutaneous lymphoma was
considered, highlighting the importance of long-term patient follow-up
Keywords
Esthetics; Lymphoproliferative Disorders; Pseudolymphoma; Skin Neoplasms
Hrčak ID:
346952
URI
Publication date:
26.2.2025.
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