Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2025.66.204
The effects of honey solution on postoperative stress, gastric motility, and patient comfort: a randomized controlled trial
Janja Tarčuković
; University of Rijeka, Faculty of Medicine, Department of Anesthesiology, Resuscitation, Emergency and Intensive Care Medicine, Rijeka, Croatia
*
Lucia Klarica
; Clinical Hospital Centre Rijeka, Department of Surgery, Rijeka, Croatia
Mario Dugonjić
; Clinical Hospital Centre Rijeka, Department of Anesthesiology, Intensive Care and Pain Medicine, Rijeka, Croatia
Ivan Vuksan
; University of Rijeka, Faculty of Medicine, Department of Anesthesiology, Resuscitation, Emergency and Intensive Care Medicine, Rijeka, Croatia
Tomislav Pavlešić
; University of Rijeka, Faculty of Health Studies, Rijeka, Croatia
Pavica Šonjić
; Clinical Hospital Centre Rijeka, Clinical Department of Laboratory Diagnostics, Rijeka, Croatia
Lidija Bilić-Zulle
; University of Rijeka, Faculty of Medicine, Department of Biomedical Informatics, Rijeka, Croatia
Miroslav Župčić
; Clinical Hospital Centre Rijeka, Department of Anesthesiology, Intensive Care and Pain Medicine, Rijeka, Croatia
Alan Šustić
; University of Rijeka, Faculty of Medicine, Department of Anesthesiology, Resuscitation, Emergency and Intensive Care Medicine, Rijeka, Croatia
Marko Zelić
; 3Clinical Hospital Centre Rijeka, Department of Surgery, Rijeka, Croatia
* Dopisni autor.
Sažetak
Aim To compare the effects of an in-house prepared hon
ey solution (HS) and a commercial carbohydrate beverage
(CCB) on postoperative stress response, gastric motility,
and self-reported comfort in patients undergoing laparo
scopic cholecystectomy.
Methods This randomized controlled trial enrolled 55
adult patients (the American Society of Anesthesiologists
physical status I-II) undergoing laparoscopic cholecystec
tomy at the University Hospital Center Rijeka from January
1, 2022, to December 31, 2022. Participants were random
ly assigned to receive either HS (n = 20), prepared from di
luted chestnut honey, or CCB (n = 35). Both solutions were
administered in the volumes of 800 mL the evening before
surgery and 400 mL two hours before anesthesia. Stress
response and inflammation were assessed by measuring
cortisol and interleukin 6 levels at six standardized time
points. Gastric motility was evaluated with a paracetamol
absorption test, and patient-reported outcomes were re
corded postoperatively using a visual analogue scale.
Results The HS group exhibited higher cortisol and inter
leukin 6 levels at multiple perioperative time points com
pared with the CCB group (P < 0.05). However, they had
significantly improved gastric motility, with higher parac
etamol concentrations 15 to 180 minutes post-ingestion
(P = 0.028-0.001). Additionally, HS group reported reduced
thirst, nausea, and pain, but had lower appetite and well
being scores.
Conclusion While HS represents a potential natural and
cost-effective alternative to CCB, further studies are need
ed to determine its role within preoperative nutrition strat
egies for enhanced recovery after surgery.
Ključne riječi
Hrčak ID:
352490
URI
Datum izdavanja:
25.6.2025.
Posjeta: 0 *