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Concentration-dependent Effects of Peroxovanadium Compound bpV(phen) on PC12 Cell Survival

Lada Rumora
Karmela Barišić
József Petrik
Tihana Žanić Grubišić

Puni tekst: engleski, pdf (155 KB) str. 419-425 preuzimanja: 377* citiraj
APA 6th Edition
Rumora, L., Barišić, K., Petrik, J. i Žanić Grubišić, T. (2005). Concentration-dependent Effects of Peroxovanadium Compound bpV(phen) on PC12 Cell Survival. Croatica Chemica Acta, 78 (3), 419-425. Preuzeto s https://hrcak.srce.hr/52
MLA 8th Edition
Rumora, Lada, et al. "Concentration-dependent Effects of Peroxovanadium Compound bpV(phen) on PC12 Cell Survival." Croatica Chemica Acta, vol. 78, br. 3, 2005, str. 419-425. https://hrcak.srce.hr/52. Citirano 20.09.2019.
Chicago 17th Edition
Rumora, Lada, Karmela Barišić, József Petrik i Tihana Žanić Grubišić. "Concentration-dependent Effects of Peroxovanadium Compound bpV(phen) on PC12 Cell Survival." Croatica Chemica Acta 78, br. 3 (2005): 419-425. https://hrcak.srce.hr/52
Harvard
Rumora, L., et al. (2005). 'Concentration-dependent Effects of Peroxovanadium Compound bpV(phen) on PC12 Cell Survival', Croatica Chemica Acta, 78(3), str. 419-425. Preuzeto s: https://hrcak.srce.hr/52 (Datum pristupa: 20.09.2019.)
Vancouver
Rumora L, Barišić K, Petrik J, Žanić Grubišić T. Concentration-dependent Effects of Peroxovanadium Compound bpV(phen) on PC12 Cell Survival. Croatica Chemica Acta [Internet]. 2005 [pristupljeno 20.09.2019.];78(3):419-425. Dostupno na: https://hrcak.srce.hr/52
IEEE
L. Rumora, K. Barišić, J. Petrik i T. Žanić Grubišić, "Concentration-dependent Effects of Peroxovanadium Compound bpV(phen) on PC12 Cell Survival", Croatica Chemica Acta, vol.78, br. 3, str. 419-425, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/52. [Citirano: 20.09.2019.]

Sažetak
Peroxovanadium compounds are potent insulinomimetic agents and protein tyrosine phosphatase inhibitors. In this study, the potential toxicity of peroxovanadium complex bpV(phen) on rat pheochromocytoma PC12 cells was examined, and the mechanism by which this compound influences cell survival and/or death was explored. BpV(phen) exerted a bimodal effect on PC12 cells: survival enhancing effect at lower and death-inducing effect at higher micromolar concentrations. 1 and 3 μmol dm–3 bpV(phen) intensely induced ERK activation. In contrast, 10 and 100 μmol dm–3 bp (phen) stimulated strong and sustained JNK and p38 MAPK activation as well as caspase-3 activation that preceded bpV(phen)-induced apoptotic cell death. It is suggested that bpV(phen) might exert its action on PC12 cell survival by modulation of MAPKs and caspase-3 activation.

Ključne riječi
peroxovanadium compounds; MAPK; caspase; apoptosis; PC12 cells

Hrčak ID: 52

URI
https://hrcak.srce.hr/52

[hrvatski]

Posjeta: 669 *