Izvorni znanstveni članak
https://doi.org/10.15255/KUI.2020.023
Release Rate Enhancement of Lurasidone Hydrochloride from Orally Disintegrating Tablets using Lyophilisation
Josipa Skočibušić
orcid.org/0000-0001-5050-5144
; Fakultet kemijskog inženjerstva i tehnologije, Sveučilište u Zagrebu, Marulićev trg 19, 10 000 Zagreb
Joško Barbarić
orcid.org/0000-0001-9539-8717
; Fakultet kemijskog inženjerstva i tehnologije, Sveučilište u Zagrebu, Marulićev trg 19, 10 000 Zagreb
Krunoslav Žižek
; Fakultet kemijskog inženjerstva i tehnologije, Sveučilište u Zagrebu, Marulićev trg 19, 10 000 Zagreb
Sažetak
This paper investigates the possibilities for release rate enhancement of lurasidone hydrochloride, a second-generation antipsychotic, by preparing solid dispersions via lyophilisation process. FTIR, DSC, and XRPD measurements have been performed in order to detect potential interactions between lurasidone hydrochloride and polymer matrices that might significantly increase drug solubility and provide faster release from the dosage form. Such solid dispersions and excipients have been used in the preparation of tablets that disintegrate in less than 3 min. In vitro dissolution profiles indicate a higher drug release rate from disintegrating tablets in comparison to pure LRS HCl.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ključne riječi
lurasidone hydrochloride; solid dispersion; lyophilisation; orally disintegrating tablet; drug release
Hrčak ID:
247621
URI
Datum izdavanja:
14.12.2020.
Posjeta: 1.847 *