Pregledni rad
https://doi.org/10.15255/KUI.2022.027
Pharmaceutical Significance of the Stereoisomerisation Process
Lucija Hok
orcid.org/0000-0003-0731-1293
; Institut Ruđer Bošković, Zavod za organsku kemiju i biokemiju, Laboratorij za računalni dizajn i sintezu funkcionalnih materijala, Bijenička cesta 54, 10 000 Zagreb
Davor Šakić
orcid.org/0000-0002-8871-6622
; Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet, Zavod za analitičku kemiju, Ul. Ante Kovačića 1, 10 000 Zagreb
Valerije Vrček
orcid.org/0000-0003-1624-8126
; Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet, Zavod za organsku kemiju, Ul. Ante Kovačića 1, 10 000 Zagreb
Robert Vianello
orcid.org/0000-0003-1779-4524
; Institut Ruđer Bošković, Zavod za organsku kemiju i biokemiju, Laboratorij za računalni dizajn i sintezu funkcionalnih materijala, Bijenička cesta 54, 10 000 Zagreb
Sažetak
Investigation of the stereoisomerisation process is of the utmost importance in pharmaceutical chemistry and biomedicine. Different isomers can exhibit significant differences when interacting with biological macromolecules, which may result in their modified pharmacokinetic and pharmacodynamic properties, thereby showing different therapeutic and undesirable effects. Although there are numerous examples illustrating the importance of stereochemistry, this article presents an overview of the most significant and representative cases in pharmacy.
Ključne riječi
stereoisomers; configurational instability; pharmacological and pharmaceutical time scales; chiral drugs
Hrčak ID:
291082
URI
Datum izdavanja:
11.1.2023.
Posjeta: 411 *