Studija slučaja
OUR EXPERIENCES IN THE TREATMENT OF CARCINOID NEOPLASMS OF THE GASTROINTESTINAL TRACT AT KARLOVAC GENERAL HOSPITAL – A RETROSPECTIVE STUDY
DRAŽEN TUFEKOVIĆ
; Opća Bolnica Karlovac, Karlovac, Hrvatska
ZRINKA BORIČEVIĆ
; Opća Bolnica Karlovac, Karlovac, Hrvatska
Sažetak
Carcinoid is a slow-growing tumor of neuroendocrine origin from enterochromaffin APUD cells. About 2/3 of it arise in the digestive tract. Carcinoid tumors make up 1% of the cancers of the gastrointestinal tract and 50% of them are located in the area of
the small intestine. They often are asymptomatic in the early stages of the disease, which makes them difficult to diagnose. It occurs most often in people at a mean age of 61.4 years. Epidemiological data show that the incidence is 2.47-4.48 per 100,000 and in the last 2-3 decades the incidence has been increasing. The cause of carcinoid tumors is unknown, but a genetic factor can play a role (it was observed in multiple endocrine neoplasia type 1, neurofibromatosis type 1, Von Hippel-Lindau disease) and
inactivation of the tumor suppressor gene on the 11q chromosome. Carcinoids are hormonally active in about 10% of cases. A relative 5-year survival is 70%-90%. In our retrospective study conducted during the 2015-2019 period, we included 10 patients with carcinoid tumors of different locations who underwent surgical treatment with 5-year follow-up. The results of treatment were similar to those reported by other authors.
Ključne riječi
carcinoid; APUD cells; gastrointestinal tract
Hrčak ID:
310553
URI
Datum izdavanja:
22.11.2023.
Posjeta: 188 *