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Review article

https://doi.org/10.17113/ftb.62.04.24.8588

Compatibility of Whole Wheat-Based Composite Flour in the Development of Functional Foods

Amani Weerarathna orcid id orcid.org/0000-0003-1477-5256 ; Department of Food Science and Technology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, 10250 Nugegoda, Sri Lanka
Matara Arahchige Jagath Wansapala orcid id orcid.org/0000-0002-7272-2016 ; Department of Food Science and Technology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, 10250 Nugegoda, Sri Lanka


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Abstract

Over the last decades, eating habits have shifted towards convenient foods with shorter preparation times due to people’s busy lifestyles and higher living standards. Rapid changes in dietary patterns and lifestyles with the industrialization and globalisation have led to the escalating incidence of chronic diseases, which has paved the way to greater interest in dietary changes regarding nutritional status and health benefits. Composite flour is a combination of wheat and non-wheat flours or exclusively non-wheat flour with improved nutritional value, therapeutic properties and functional characteristics. The application of composite flours in the food industry is an important milestone that maximises the use of indigenous crops while optimising the product quality, nutritional value, organoleptic properties and consumer acceptance. This paper provides a comprehensive overview of the suitability and compatibility of alternative composite flours in the food industry with regard to the existing formulations. Furthermore, the suitability of composite flours in food products in terms of nutritive and therapeutic value is emphasised. It was found that food products with higher nutritional and therapeutic value and acceptable sensory properties can be formulated by blending different non-wheat flour sources with wheat flour at different ratios. Composite flours have the potential to reduce the risk of non-communicable diseases, particularly type 2 diabetes, cardiovascular disease and cancer. It can be concluded that the use of composite flours in the food industry is a trending approach due to their numerous benefits.

Keywords

composite flour; whole wheat flour; sustainable alternative flour

Hrčak ID:

326738

URI

https://hrcak.srce.hr/326738

Publication date:

14.1.2025.

Article data in other languages: croatian

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INTRODUCTION

Wheat, the staple food in many parts of the world, is responsible for around a fifth of the world’s calorie supply. This is virtually a quarter of the calorie intake from grains, which provide almost half of the calories consumed worldwide. The preference for wheat is based on its ability to serve as a basic ingredient in different products, particularly bread, noodles, pasta, cakes, pastries, crackers and flatbread products. Wheat is the most traded grain because its robustness and longer shelf life in the absence of humidity and rodents make it more suitable for transport and storage than any other commodity. The development of wheat consumption shows the displacement of staple foods that have been used as the main source of calories in different parts of the world. The key factors that describe the development of wheat consumption in developing countries are population growth, income growth, determination of the relative prices of wheat and other staple food and the preferences of end consumer. Drastic population growth and rising incomes significantly increase the demand and thus the wheat consumption. End consumer preferences are either determined or perhaps induced by technology, lifestyle and income. Furthermore, the increasing employment of women has encouraged the shift in dietary patterns towards convenient foods with less preparation time, thus favouring the use of wheat-based products (1).

Consumers prefer refined wheat-based products to whole grain wheat-based products because the texture, eating quality and taste of whole wheat-based products are less appealing (2). The removal of outer layers of whole wheat grains, which are rich in nutrients and bioactive compounds, during milling results in the loss of important health benefits of the grain. The refined wheat-based products have a high content of digestible carbohydrates with high glycaemic index (GI), low amounts of minerals, B-group vitamins, polyphenols, β-carotene and dietary fibre, and a low quantity and quality of proteins (3-5). The consumption of foods with high glycaemic index exacerbates the incidence of type 2 diabetes and other cardiometabolic diseases, which have been recognised as a major socio-economic burden worldwide. Therefore, immediate dietary interventions are needed to develop appropriate low GI foods with high palatability to effectively prevent and regulate type 2 diabetes and improve cardiometabolic health (6). Moreover, despite the increasing consumption of wheat-based products around the world, a wide spectrum of health complications associated with wheat intolerance have been reported (7). Three possible wheat-related disorders, namely wheat allergy (WA), coeliac disease (CD) and non-coeliac wheat sensitivity (NCWS), have been detected in susceptible individuals exposed to either wheat or wheat components, particularly wheat protein (8). Gluten, the primary storage protein in wheat, has been identified as the major culprit for the onset of wheat-related diseases (7). CD is a chronic autoimmune disease triggered by the ingestion of gluten and causes small intestinal mucosal damage in hereditarily predisposed individuals (8,9). The worldwide prevalence of CD based on a diagnosis confirmed by biopsy and serology is 0.7 and 1.4 % respectively (10). CD leads to villous atrophy, which flattens the villi in the small intestine and reduces the surface area for absorption of nutrients, leading to various complications such as malnutrition, micronutrient deficiencies and gastrointestinal symptoms, particularly bloating, nausea and abdominal discomfort (7). Although gluten is beneficial for maintaining the viscoelastic properties of baked goods, consumer interest has shifted from wheat-based products to wheat-substituted products due to the aforementioned consequences (11).

Recently, a rapidly growing demand for functional foods, also known as health-promoting and disease-preventing foods, has been observed as consumer awareness and interest in health and nutrition has increased (12). Fruits, vegetables, whole grains and legumes have been included in the diet because the link between diet and disease has been recognized to provide a substantial amount of bioactive components such as phytochemicals, dietary fibre and protein. These components impart specific physiological benefits to functional foods (2,12). There is growing evidence that regular ingestion of whole grains can reduce the risk of chronic degenerative diseases and obesity (4). The antioxidant capacity of whole grain phytochemicals, particularly polyphenols, is responsible for the alleviation of oxidative stress, resulting in the delayed onset of some chronic diseases (13). This has led to the consideration of fortification or substitution of whole wheat flour with other non-wheat cereal flours (4).

COMPOSITE FLOUR TECHNOLOGY

Composite refers to the combination of two or more components with the aim of creating a novel product that is superior to the individual components in terms of improved properties, performance or economy (14). Since 1960, mixed flours or blends have been scientifically referred to as composite flours. Currently, composite flour is simply introduced as mixture or replacement of various types of flour with or without wheat flour (15).

The need for composite flour arose with the scarcity of wheat due to climatic or economic fluctuations and the development of scientific knowledge about the adverse health effects of wheat flour (16). Inadequate climate for wheat cultivation around the world has led to the extensive use of non-wheat grains in the bakery industry. For instance, rice in South and East Asia, maize in central and South America, millet and sorghum in Africa and rye and oat in Northern Europe. In addition to the aforementioned reasons, the occurrence of lower yields and inferior quality of wheat due to global climate change has encouraged the extensive use of other cereals that can be grown further than the borders of Africa and Asia due to global warming (17).

Moreover, the blending of wheat flour with non-wheat flour is economically and nutritionally beneficial (16). As far as economic importance is concerned, the main reasons for the greater interest in composite flours in developing countries are to save foreign exchange by reducing wheat imports and thus encourage local agriculture (4,15). Enhancing the value of domestic agriculture through better utilisation of local crops helps to reduce dependence on imported wheat and ultimately ensure food security (4). Composite flour products can be offered at affordable prices for low-income groups due to the use of cheaper substitutes (18). On the other hand, composite flours have a greater nutritional importance. Compared to wheat flour, they have a better nutritional profile with a high protein and vitamin content. Moreover, composite flours can be recognised as a healthier product for people suffering from malnutrition and health problems (15). In addition, the increasing prevalence of coeliac disease and other gluten-associated allergies has triggered the demand for non-wheat flour-based products (4). Each individual component of the composite flour has a characteristic colour, texture and nutritive value that can enhance its use in various food products (15). Although numerous studies have been carried out on the subject of composite flours, a greater number of studies have focused on partial substitution of wheat flour rather than the complete replacement.

SUSTAINABLE ALTERNATIVES FOR COMPOSITE FLOURS

Cereals

Maize and rice can be introduced as the most important cereal grains in the human diet alongside wheat (4). Rice is an important staple food for more than half of the world’s population, especially for Asians (19). Recently, researchers have focused more attention on different rice varieties due to their health benefits, high amounts of bioactive compounds and resistant starch (20). Rice is superior to other cereals due to its low sodium content, high content of easily digestible carbohydrates and hypoallergenic properties (19). The most important antioxidants in different rice varieties are polyphenols such as anthocyanins, proanthocyanidins and phenolic acids concentrated in red, black and white rice respectively (20). Pigmented rice varieties have anticancer (21), antidiabetic (22,23) and antioxidant (21) properties (24). Rice flour does not contain a unique wheat gluten protein and is often consumed by coeliac patients either as cooked rice or as flour. Black rice varieties have been identified by in vitro digestion as a suitable dietary intervention for coeliac patients due to their potential antioxidant and anti-inflammatory effects (25).

Maize is the third most important staple cereal consumed worldwide. It is considered a versatile crop that has many uses worldwide, including as livestock feed, for human consumption and other non-food purposes (26). Despite the fact that white and yellow maize varieties are mainly used for human consumption, an increasing consumption of pigmented varieties has been observed due to the functional properties, especially antioxidant properties of anthocyanins that are responsible for the colour of the coloured varieties (27). A study reported that combination of maize and whole wheat flour increased the ash, fat and fibre content of the composite flour without affecting the organoleptic properties up to 20 % of maize (28).

Although the major cereals contribute to more than 50 % of the global caloric demand, they are significantly deficient in phytonutrients and micronutrients, especially vitamins and minerals. On the contrary, certain minor cereals and pseudocereals, which are nutritionally equivalent or even superior to the major cereals, serve as excellent sources of phytonutrients and micronutrients (29). Minor cereals include sorghum, millet, barley and oats, while pseudocereals consist of amaranth, buckwheat and quinoa (30). The health benefits of cereals and pseudocereals are shown inFig. 1 (31-44).

Fig. 1 Health benefits of cereals and pseudocereals (31-44)
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Millet and sorghum are known as important food crops in sub-Saharan Africa and south Asia (30). They are affordable, available and can have positive effects on human health and nutrition (45). Millets are considered as an important cereal with a high dietary fibre, micronutrient and phytochemical content. Finger, kodo, barnyard, little and pearl millet belong to the millet group (46). The addition of sorghum and pearl millet flour to the whole wheat flour in the production of certain flatbread products (i.e. chapattis and biscuits) leads to reduced GI of the products (47). Sorghum and millet enhance the hypoglycaemic effect of food products and play a crucial role in the regulation of hyperglycaemia (45-48). They are also beneficial in reducing serum triglyceride and cholesterol values (49,50), body mass management (51,52) and reducing the risk of gastrointestinal ailments (30,53,54). Barley is the fourth most important cereal worldwide (55). Barley and oats are ideal sources of β-glucan, water-soluble dietary fibre, with amounts of 2.5–16 and 2.3–8.5 %, respectively (56,57). β-glucans are able to lower glycaemic index and increase the insulin response in diabetic patients (55,58). They can also improve lipid metabolism, mitigate the occurrence of coronary heart disease by lowering plasma cholesterol (55,59) and reduce gastrointestinal disorders (55,57,60).

Psuedocereals

Buckwheat is the well-known type of pseudocereals. It has higher protein (14.94 %), ash (1.855 %), total phenolic (expressed in gallic acid equivalents, 21.64 mg/g) and antioxidant content (expressed in Trolox equivalents, 131.36 mg/g) than whole wheat flour (11.92, 1.202, 5.66 mg/g and 15.91 mg/g, respectively) (61,62). The antioxidant activity of buckwheat is attributable to hyperin, rutin, quercetin and catechins, which have numerous health benefits (63). Buckwheat is able to reduce the risk of hypertension (64), hypercholesterolaemia (65) and diabetes (65) as it contains nutrients such as thiamin-binding proteins, flavonoids and proteins that can have favourable effect on the regulation of blood pressure, serum cholesterol and glucose level (61,63). Quinoa, also recognised as a ’complete food’, is an excellent source of minerals (calcium, iron, zinc and copper), vitamins (B1, B2, B3 and E), phytochemicals (phytosterols, saponins and phytoecdysteroids), unsaturated fatty acids and essential amino acids (methionine, lysine and threonine) (66). Due to its high fibre content, quinoa plays a crucial role in diets intended to reduce the risk of cardiovascular diseases and obesity. Quinoa flour also contains higher protein content (15.96 %) (63). Quinoa is known to have a favourable effect on human gastrointestinal (67), cardiovascular (68) and metabolic health (66,69-71). Amaranth flour has higher protein, vitamin (folate and B12) and mineral content (iron, magnesium, potassium and phosphorous) than whole wheat flour. Water-holding capacity (WHC), which depends on the interaction between fibre and protein, is higher in amaranth flour than in whole wheat flour. Viscosity, stability and textural properties of the products can be improved by high WHC of flours. Textural properties of amaranth show higher correlation with its pasting properties. The stability of the paste made from amaranth starch is higher than that of rice, corn, wheat and potato starch. Amaranth has the potential to increase antioxidant capacity, improve different immune parameters, mitigate blood pressure and reduce cholesterol when consumed frequently (72-75). Buckwheat and amaranth are categorised as low GI foods, while quinoa has a medium GI. Therefore, these pseudocereals can be used as functional ingredients in novel product formulations to regulate the glycaemic impact of the final product (61).

Legumes

In contrast to the past, the demand for functional foods with increased nutritional value, e.g. products that can fulfil the nitrogen and amino acid requirement of the body, has increased due to people’s health awareness. Meanwhile, the consumption of plant proteins instead of animal proteins has become a global trend in the context of environmental conservation and the reduction of gas emissions (76). Dry beans, chickpeas, dry peas, lentils, cowpeas and broad beans are important crops belonging to legume family (77). Flours made from pulses are used as supplements of wheat flour due to their higher protein content (76). Wheat flour is blended with pulses to improve the balance of essential amino acids and thus the protein quality, as cereal proteins are deficient in lysine but rich in sulphur-containing amino acids, especially methionine and cysteine, while legumes are a rich source of lysine but deficient in sulphur-containing amino acids (78). Yellow peas, green peas, red lentils and chick peas have a higher protein content (19.82, 21.78, 23.72 and 22.19 %) and a higher ash content (2.32, 2.38, 2.10 and 2.66 %) than whole wheat flour (15.13 and 1.80 %) (79). People suffering from hypertension (80) and hyperglycaemia (81) benefited from the consumption of bean flour due to the phenolic compounds that can inhibit enzyme activity (82). Moreover, chickpea flour has been recognised as a hypoglycaemic agent that plays a crucial role in the regulation of type 2 diabetes due to the presence of a proteinaceous fraction and specific polysaccharides identified as potent inhibitors of the enzyme α-amylase (82). The therapeutic importance of legumes is shown inFig. 2 (83-88). Legumes are often overlooked because of the antinutritional factors. Nevertheless, mung beans have been considered due to their comparatively low content of antinutrients, considerable amount of proteins (24 %), vitamins, minerals and bioactive compounds. Therefore, the use of mung beans resulted in enrichment of low-protein products and alleviation of protein malnutrition (89). Another study showed the potential of common beans (22.73 % protein content) as a protein supplement. Despite their nutritional benefits, common beans are beneficial in the treatment of coronary heart disease, diabetes, obesity and cancer (81,90-92). Although pigeon pea is underutilised due to its hard-to-cook nature, it is a good source of protein, fibre, vitamin B complex, minerals and has a low GI (93). Horsegram has been recognised as a potential ingredient in the formulation of commercial food products, especially bakery products or as a partial substitute in composite flours. The addition of horsegram improved the nutritional value of the products by increasing the protein, micronutrient and dietary fibre content. In addition, phenolic compounds, dietary fibre and complex carbohydrates help to reduce the GI and alleviate obesity, diabetes and heart diseases (94-97).

Fig. 2 The therapeutic importance of legumes (83-88). GI=glycaemic index
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Although the addition of pulse flour improved the nutritional value and therapeutic properties of composite flour, dough viscosity and stability decreased because the dilution of gluten with the increasing amounts of pulse flour hindered the development of the gluten network. Specific volume and hardness of the formulated bread loaves were reduced by the increased proportion of pulse flour (79). Water absorption capacity of the composite flour was improved with the addition of red kidney bean flour, as it increased the fibre and protein content of the composite (98). Moreover, the addition of green gram flour also increased the water absorption capacity of the composites due to the high water-attracting polar amino residuals. The oil absorption capacity illustrates the ability of protein matrix to bind with fat via capillary action (89). Protein, which consists of hydrophilic and hydrophobic components, is the most important chemical compound that affects the oil absorption capacity (98). Better hydrophobicity as a result of increased non-polar amino acids exposed to fat with increasing protein content of the composite, increases the oil absorption capacity of the composite flours (92). Therefore, greater attention has recently been given to the use of pulses as a functional ingredient in various food products without affecting the desirable properties of the product and its eating quality (94).

Roots and tuber crops

The most important root crops, namely cassava and sweet potato, and the most important tuber crops, particularly cocoyam, potato and yam, are consumed as staple or secondary staple crops. Root crops play a vital role in ensuring food security due to their inherent advantages and climatic resilience to extreme and unpredictable environmental fluctuations (99). Cassava has been recognised as a cheap and important source of carbohydrates that can be used as a promising substitute for wheat flour (100). Increased addition of cassava flour reduced the protein content of the composite flour due to its low protein content (101). Water absorption capacity, a favourable property in dough handling, is increased by the addition of high-quality cassava flour because the weak molecular arrangement and inadequate network architecture of cassava starch improve the penetration of water (89,101). Sweet potato can contribute to food security in developing countries as it has a short maturation period and can grow under unfavourable conditions. Moreover, it is an excellent source of β-carotene, minerals, vitamin C, B1, B2 and B3. Since sweet potato flour has a lower fat content (1.5 %) than whole wheat flour (3.90 %), it reduces the fat content of the final products, which has a positive effect on shelf life as it prevents rancidity. Products containing sweet potato flour provide the body with substantial amounts of fibre because sweet potato flour has a higher fibre content (3.28 %) than wheat flour (0.32 %) and helps to control the bowel integrity, reduce blood cholesterol and regulate blood sugar levels (102-105). Taro roots, which are easily digestible, are a better source of fibre (2.81 %), calcium and potassium (12 and 254 mg/100 g) than whole wheat flour (1.54 %, 0.217 and 1.762 mg/100 g, respectively). Functional properties of composite flour, including water and oil absorption capacity, increased with the addition of taro root. Taro can be used as an effective raw material in composite flours to improve the nutritional and functional properties of whole wheat flour (106). Cocoyam, an underutilised tuber, improved the nutritional value and affordability of wheat-based products (107). Cocoyam has a relatively higher mineral content (calcium, magnesium and phosphorus) and more digestible protein fraction than other important roots and tubers (99).

Fruits and non-leafy vegetables

Recently, greater attention has been paid to the use of natural raw materials for the development of functional foods that can positively affect human metabolism and promote healthy lifestyle through complete nutritional profile (108). Important health benefits of the main alternative plant sources other than cereals and legumes are shown inFig. 3 (109-112). The bioactive compounds, the type of carbohydrates, the amino acid and fatty acid profiles of the natural food components can modify the food products to achieve an optimal nutritional balance. Vegetables have a beneficial effect on human health due to the presence of phyto-nutraceuticals, including minerals, vitamins and dietary fibre. Composite flour containing cauliflower can be recommended as a multifunctional flour mixture as cauliflower contains easily available bioactive compounds. Moreover, the addition of vegetables increases the ash content due to the high mineral content (108).

Fig. 3 Health benefits of sustainable alternative flours (109-112)
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Avocado, known as a super-supplement due to its superior nutritional profile and numerous health benefits for humans, is used in the development of functional foods. The addition of avocado pulp improved the antioxidant activity, total phenolic, total flavonoid and carotenoid content, as well as high-quality fatty acid profile of whole wheat chapattis (113). Blending whole blackberry flour with whole grain wheat flour increased the total dietary fibre, total phenolic and anthocyanin content of the composite flour, improving its sensory properties, nutritional quality, antioxidant properties and health benefits (114).

Mushrooms

Mushrooms are considered an unused food source of great culinary and therapeutic importance (115). The addition of mushroom to bread improved antioxidant activity and total phenolic content due to the higher content of glutathione and ergothioneine as antioxidants in mushrooms (108). Oyster mushrooms have been used as an ingredient in the development of functional cookies due to their therapeutic properties attributable to a wide range of bioactive compounds (115). They have shown antimicrobial and antioxidant properties as well as cytotoxic effects (116,117). Moreover, mixing oyster mushrooms increased the protein, fibre and ash content of whole wheat flatbread (118). In addition, powders of lion’s mane, turkey tail and reishi mushroom showed antimicrobial (119-121), antidiabetic (122-124), antiobesity (125-127), anticancer (121,128,129) and neuroprotective (130-132) properties, which could be due to numerous bioactive constituents with different configurations (133).

Green leafy vegetables

Green leafy vegetables are cost-effective and nutrient-rich food that, in addition to their nutritional importance, contain a wide range of non-nutritive bioactive compounds that can have therapeutic properties. These vegetables are an excellent source of vitamins such as vitamin C, B2, E, folic acid and provitamin A compounds such as β-carotene and they contain significant amounts of minerals (e.g. iron, phosphorus and calcium). Therefore, the addition of green leafy vegetables plays an important role in nutrient deficiencies (111). The ash, protein, fibre, calcium, magnesium, zinc, iron, potassium and total phenolic content of moringa leaf flour are higher than of whole wheat flour. Moringa leaves also have antidiabetic (134), anticancer (135), antioxidant and antimicrobial properties (136). The addition of moringa leaves improved the antioxidant, nutritional and therapeutic properties of whole wheat flour (137). Spinach is considered as a naturally enriched green leafy vegetable with more ash (2.99 %), protein (19.18 %), fibre (8.19 %), sodium (98.20 mg/100 g), calcium (1303.9 mg/100 g), iron (40.36 mg/100 g) and zinc (13.38 mg/100 g) than whole wheat flour. Despite the improvement in nutritional and health benefits, the addition of spinach powder affected the rheology of the dough, while dough development and stability decreased with increasing amount of substitution (138). Green leafy vegetables have a known potential as functional ingredients that can be used to enrich or fortify food products (111).

Herbs and spices

Spices themselves will not become a staple food, but they can improve the functional profile of food. The use of spices as flavour additives dates back thousands of years. Spices impart colour, flavour and aroma to foods while extending their shelf life. Spices and herbs have significant antioxidant properties due to phenolic compounds (139). The energy value, fat and protein content of composite flour increased with the addition of even a small amount of germinated fenugreek powder (5 %). Better nutritional and acceptable organoleptic properties of cookies baked at 175 °C were obtained by adding 10 % fenugreek flour (140). Dietary spices can also improve the digestive properties of food by stimulating the secretion of corresponding enzymes present in food. The addition of 1 and 2 % ajwain, cumin, cinnamon, black pepper, fennel and ginger increased the protein digestibility of whole wheat flour (141). Oregano and bay leaf improved the radical scavenging activity of whole wheat and meat-based bread. The high content of carnosic acid, rosmarinic acid and carnosol in oregano and the high content of methyl eugenol and eugenol in bay leaf could be responsible for their antioxidant potential. They also act as natural preservatives that reduce oxidative stress and microbial deterioration during storage (142). Saffron, considered a high-value spice worldwide, is not only used in cooking for its flavour and colour, but also has therapeutic properties including antidiabetic (143), cardioprotective (144), anticancer (145) and antidepressant effects (146,147). Therefore, spices can be used as functional ingredients to increase the nutritional value and medicinal properties of food (139).

Nuts and seeds

Whole wheat muffins with added flaxseed are known as an appropriate functional food for people with cardiovascular disease and obesity (148-150). Chia seeds have high ratio of polyunsaturated fatty acids, α-linolenic acid (50–57 %) and a low ratio of linoleic acid/α-linoleic acid (LA/ALA). The lower the LA/ALA ratio, the greater the health benefits. Adding chia seeds to the diet helps prevent cardiovascular disease (151,152). A dietary fibre-enriched product can be made by mixing whole wheat flour with peony seed oil (15 g) and chia seeds (12 g) to improve antioxidant activity (153). The addition of prehydrated chia seeds or flour optimised the specific volume, texture and acceptability of the bread better than the untreated seeds or flour (154). The whole wheat biscuits with added walnuts have better shelf-life stability due to the higher antioxidant activity (155). The addition of cashew nuts to whole wheat composite bread resulted in an improved flavour and taste profile. Moreover, the addition of larger amounts cashew nut flour had a significant effect on the viscosity and consistency, resulting in an excellent mouth feel and overall sensory experience (156). Peanuts are known as an underutilised plant with high nutritional value. Peanut-enriched whole wheat flatbread has improved textural, antioxidant and sensory properties as well as higher macro- and micronutrient content (157).

Fruit and vegetable side streams

Recently, the use of side streams from the food industry in the development of functional foods has attracted attention from an economic point of view as it reduces waste disposal costs, from a socioeconomic point of view as it improves nutritional value of products for consumers, and from an environmental point of view as it reduces waste disposal. Side streams include peels, seeds, juice and stems (158,159). The increased content of flavonoids and polyphenols as well as antioxidant activity of whole wheat flour with added date seed powder show that it is a functional food ingredient. Date seeds have been recognised as a promising source for averting liver damage and preventing hepatotoxicity in rats (158,160). The addition of jackfruit seed flour improved the nutritional value of the composite flour as it had higher ash (3.4 %), protein (13.3 %), fibre (5.1 %), calcium, magnesium, potassium and phosphorus content (68.4, 161.6, 1454.4 and 301.7 mg/100 g, respectively) than whole wheat flour. In addition, bioactive and phytochemical ingredients have antidiabetic (161), antioxidant (162) and anti-inflammatory (163) properties, which provide various health benefits to humans (164). Orange peels contain multiple bioactive compounds, including flavonoids and cinnamic acids, and have various health-promoting properties, such as anticarcinogenic (165), anti-obesity (166) and anti-diabetic (167) properties. Despite the fact that apple and cherry tomato peels have significant health benefits, the addition of these peel flours to whole wheat flatbread led to the formation of acrylamide (133). Another study reported increased nutritional value and mineral content (i.e. iron, potassium, calcium, sodium and magnesium) of whole wheat cookies with added avocado/banana peel (168). Apple pomace, Indian gooseberry pomace powder and bottle gourd peels were identified as potential alternatives in whole wheat composite flour because of their higher content of ash, fibre, pectin, vitamin C, total phenols and better health benefits (159).

Microalgae

Recently, there has been an increased focus on the supplementation of microalgae, as they contain promising bioactive compounds that can act as functional components (169). Microalgal biomass is widely used as dietary supplements, herbal products and nutrient isolates. In addition to the direct consumption of microalgal biomass, they can be used in novel food formulations due to their balanced chemical composition, especially their versatile fatty acid profiles, antioxidants, vitamins, minerals and high-quality proteins, as well as their specific interesting properties (169,170). The integration of microalgae into the diet confers therapeutic properties such as cardioprotective, anticancer, antioxidant, immunomodulatory and chemoprotective properties (171).

Spirulina, a blue-green filamentous microalga, is an excellent source of protein (60–70 %) with high biological importance due to its vitamins (vitamin B12 and provitamin A), minerals (iron, calcium and magnesium) and bioactive compounds (total phenols, chlorophylls, carotenoids and flavonoids) (169,171). They have antioxidant (172), antidiabetic (172), immunomodulatory (173), antihypercholesterolaemic (174), anticancer (175) and anti-inflammatory activity (175). Spirulina has been recognised as a potent candidate for functional foods due to the above benefits. It has increased the protein digestibility of whole wheat flour bread (170). Moreover, spirulina has contributed to the improvement of the amino acid profile, nutritional value and bioactive parameters of whole wheat pasta (171). Nannochloropsis microalgae are known for their higher content of eicosapentaenoic acid (EPA), which is beneficial in biological membrane functions. The addition of Nannochloropsis to the pasta significantly increased the protein, ash, lipid and EPA acid content (176). The combination of Haematococcus pluvialis, astaxanthin and dietary fibre-rich marine-derived microalgae significantly reduced the rate of glucose release during in vitro digestion of whole wheat cookies. The addition of microalgae thus reduced the glycaemic response and improved the bioactive compounds of whole wheat cookies (177).

APPLICATION OF COMPOSITE FLOURS IN FOOD INDUSTRY

There is an increasing interest in the successful use of composite flours in the development of a wide range of food products, especially bakery products, with the intention of improving the functional and technological properties of the final product. Different amounts of different types of flour are mixed with wheat flour to develop bakery products. The amount to be replaced is determined by the quality and quantity of wheat proteins, as it determines the desired degree of dough viscosity, plasticity and elasticity, to obtain the quality of the final product (100,178).

The use of different food components in product formulations is determined by the functionality of each ingredient, i.e. the properties other than nutritional value that regulate the behaviour of foods during different treatments (89). For instance, too high or too low water absorption capacity of flours has a detrimental effect on product quality. A higher water absorption capacity is preferred for the development of texture of bakery products such as bread and biscuits (92). Water absorption has a positive effect on loaf volume, fracture stress of bread crumb, proofing and bread yield. Excessive water absorption leads to a large bread volume, an open crumb with oversized cells and an increased susceptibility to mould, while insufficient water absorption leads to a small bread volume with a firm and dense crumb structure (98). A higher oil absorption capacity of composites leads to a better flavour, mouthfeel, texture of the food and a longer shelf life, especially of bakery products (89,92).

The bakery products made from composite flour were of good quality with improved nutritional value and appearance. Despite the fact that composite flour products have some similar properties to wheat flour products, there were differences between the two derivatives in terms of textural, functional and sensory properties. Previous studies emphasised the need for additional efforts to improve the bread quality with higher additions of gluten-free flours. The gluten content and the viscosity of the starch determine the influence of alternative flours on the wheat addition and thus on the baking quality. Physical properties of the formulated bread, particularly loaf volume, mass and specific volume, are bread quality attributes that evaluate the effect of the alternative flours (89). The addition of alternative flours reduced the amount of gluten in the composite flours, resulting in reduced carbon dioxide retention and ultimately a reduction in the height, loaf volume and specific volume of the composite breads. Moreover, the loaf volume decreased with an increasing amount of legume flours, as the comparatively larger particles of legume flour can penetrate gas cells during dough expansion. The size of the baked dough, the moisture and the amount of CO2 gas diffused from the loaf during baking determine the bread mass. Composite breads have a higher loaf mass due to the lower CO2 retention. The specific volume has been recognised as a credible measure of loaf size. The minimum hydration capacity relevant for composite flours could be the reason for the lower specific volume (93). Greater quantities of open crumb pores and larger crumb cell walls were observed with the increasing amount of pulse flour. Bread hardness increased with the higher proportion of pulse flour due to the increased starch retrogradation (79).

Physical parameters related to the cookies are mass, thickness, diameter and spread ratio. A higher amount of alternative flours with the ability to increase the amount of water-absorbing fibre reduced the spread factor of the cookies, resulting in cookies with a smaller diameter and higher thickness. The robust protein interaction between the individual flours of the composite mixture determined the hardness of the cookies (46). In addition, the interaction between gluten and fibre affected the hardness of the cookies, as the dietary fibre content increased the water absorption capacity and influenced the gluten development time. Higher amounts of date seed powder reduced the hardness of the cookies due to the high dietary fibre content (158). The spread ratio of the cookies and their fat content are known to be directly corelated. The researchers observed a reduction in the spread ratio of the cookies by adding crude lycopene, a fat-soluble component, which reduced the amount of free fat available for wheat flour. Furthermore, the addition of tomato powder was observed to increase the hardness of the cookies due to the increase of fibre content (179). Previous studies reported increased mass in composite cookies due to the higher moisture content of fenugreek and higher bulk density of the flour mixtures. Moreover, the higher protein content of oats and fenugreek reduced the spread ratio of the cookies (140).

The cooking properties determined the quality of the developed pasta. Fractionated whole wheat and bambara ground composite pasta had a shorter optimum cooking time (OCT) than the control pasta made from unfractionated flour. Fractionated flours had shorter OCT because they contained larger particle sizes. Larger particles, particularly germ and fibre, facilitate water absorption and reduce the preparation time (180). Higher insoluble dietary fibre (IDF) amounts prevent complete gelatinisation of starch, as IDF competes with starch for water and ultimately shortens cooking time and thus saves energy. Cooking loss is another critical quality parameter for pasta. The higher the cooking loss, the lower the quality of the pasta. Smaller quantities of alternative flours cannot considerably weaken the gluten-starch matrix and therefore have no significant effect on cooking loss. The addition of high-fibre alternative flours reduced the hardness of the pasta by weakening the gluten matrix of the pasta structure (181). Some research on the successful use of composite flours in the food industry is shown inTable 1 (19,45-47,55-57,66,79,82,89,92-94,98,100-102,107,108,115,137,138,140,142,147,148,151,158,168,179,180,182-198).

Table 1 Application of composite flours in food industry
ProductComposite flourAcceptable
ratio
Specific nutritive propertiesSpecific functional propertiesRef.
BreadWhole wheat/yellow pea95:5Increased ash and protein content of the flour mixture reported due to the incorporation of yellow peaImproved rheological properties (i.e. handling, mixing and pasting properties) compared to whole wheat flour dough
The
specific volume and bread quality are comparable with whole wheat bread
(79)
Whole wheat/acha/pigeon pea/date palm fruit sugar60:20:20:100Increased
protein, crude fibre and mineral content (i.e. Na, K, Ca, Mn, Zn)
Considerable phytate content and lower amount of oxalate
Low glycaemic index
Reduced specific volume, volume and height, and increased mass (i.e. denser bread) (93)
Whole wheat/watermelon seed97.5:2.5Increasedprotein and fibre content and lower carbohydrate and ash content
Increased minerals
(i.e. iron, phosphorous and magnesium)
Lower tannin and oxalate content
Improved loaf mass, volume and decreased specific volume (182)
Whole wheat/sweet lupine75:25Increased protein
and mineral content (specifically calcium and zinc)
- (183)
Whole wheat/chickpea60:40Reduced glycaemic responseReduced specific volume (82)
Whole wheat/cassava/green gram90:5:5Increased fat, protein and fibre content.Increased loaf mass, reduced volume and specific volume, sensory properties
comparable to 100 % whole wheat bread
(89)
80:10:10Elevated ash, fat, protein and fibre content.Increased loaf mass, volume and specific volume. Comparable with 100 % wheat bread
Whole wheat/chicken meat powder/amaranth/oregano/bay59.50:30:10: 0.5Enhanced antioxidant activity and storage stabilityEnhanced overall acceptability and structural integrity during storage compared to whole wheat bread (142)
Whole wheat/chia seed/quinoa/amaranth67:10:4:19Increased soluble and insoluble dietary fibre, total dietary fibre, ash and protein content
Reduced caloric value and GI
Specific volume, shape ratio and crumb structure 100 % comparable to whole wheat bread (151)
Whole wheat/cocoyam/bambara ground70:18:12Elevated fibre, protein and ash contentComparable with 100 % whole wheat bread with respect to sensory properties (184)
Whole wheat/mutamba fruit flour95:5Improved bioactive content and reduced caloric value in the breadLoaf volume reduced with the increasing amounts of substitution (185)
Whole wheat/brown seaweed96:4Increased ash and total dietary fibre contentSoft and chewy bread with no significant aftertaste (186)
Whole wheat/red seaweed98:2Increased ash, protein and total dietary fibre content
Whole wheat/red kidney bean/defatted coconut flour90:5:5Increased protein, ash, fat, fibre, phytate, oxalate and tannins contentHard crumb texture (98)
Whole wheat/sorghum/millet (prefermented in the presence of exopolysaccharides)50:50Enhanced nutritional value.
Reduced GI
Hard texture and brown coloured crumb structure (45)
Whole wheat/cassava90:10
80:20
Increased ash contentPromoted gumminess,
cohesiveness and resilience of bread
(100)
Whole wheat/cocoyamAcceptable: 85:15Increased content of fibre, ash and fatReduced textural attribute of bread due to the reduction of dough elasticity with the increasing amounts of substitution (107)
Most acceptable:
95:5
Whole wheat/vegetable paste (mushroom/cauliflower/pea)85:15Increased ash, protein and total phenolic content
Enhanced antioxidant activity
Reduced loaf volume and increased hardness (108)
Whole wheat/moringa leaf powder95:5Increased ash, protein, fibre content and calories. Calcium, potassium, magnesium, zinc contents and anti-oxidant capacity improvedIncreased gumminess and reduced hardness and springiness of bread (137)
Flat breadWhole wheat/stabilised rice bran/undamaged- stabilised-debittered wheat germ75:10:15Increased protein, ash and total dietary fibre content and
lowered starch digestibility
Improved water absorption capacity,
dough mixing and handling properties
(187)
Whole wheat/extruded finger millet80:20Increased dietary fibre, protein, iron and calciumImproved extensibility and reduced resistance to extension
(i.e. soft and less firm flatbread)
(188)
Whole wheat/barley80:20Increased content of ash, protein, β-glucan and energy and
reduced carbohydrate content
Improved water absorption capacity, dough development time and reduced dough stability (57)
Whole wheat/fenugreek gum99.25:0.75Increased moisture contentSensory qualities similar to 100 % whole wheat flatbread.
Excellent pliability and softness observed up to 2 days of storage
(189)
Whole wheat/barley75:25Increased crude fibre, ash content and reduced fat and protein content
Low glycaemic index
No significant difference in sensory properties with up to 25 % barley flour addition
Reduced extensibility and force to tear
(55)
Whole wheat/broken rice flour80:20Higher digestible starch and lower resistant starch
Increased GI
Dough development time and stability increased
Reduced shrinkage and
bake loss
(19)
Whole wheat/sorghum/pearl millet40:30:30Reduced GIImproved hardness and stiffness (47)
Whole wheat/spinach92.5:7.5Increased protein, ash, fiber, potassium, calcium and iron contentReduced water absorption, dough development time and stability
Enhanced hardness, springiness and chewiness
Reduced puffed height
(138)
CookiesWhole wheat/common bean/pumpkin75:15:10Increased protein, fat, ash and crude fibre contentsReduced lightness and specific volume
Increased spread ratio
(92)
Whole wheat/pearl millet/sorghum30:40:30Reduced GI- (47)
Whole wheat/horse gram flour75:25Enhanced nutritional valueIncreased spread ratio and
reduced mass, diameter and thickness
No adverse effect on the overall acceptability
(94)
Whole wheat/soy okara/tigernut60:20.98:19.02Increased fibre ash, magnesium, iron and sodium contentNo significant difference in mass, diameter, height, appearance, mouthfeel, crunchiness and crispiness
Significant difference in spread ratio and thickness
(190)
Whole wheat/sorrel seed protein isolate/cassava flour85:5:15
70:10:20
55:15:30
Significantly increased crude protein, fat, fibre, ash, mineral content
Reduced carbohydrate content
Increased mineral content with increased substitution
No significant difference in the sensory attributes of cookies, except crispiness at all level of inclusion
Improved pasting and functional properties
(101)
Whole wheat/unripe plantain/germinated pumpkin seed90:5:5Significantly increased crude protein, fat, fibre and ash content
Reduced carbohydrate.
Increased tannins, oxalates and phytates
No significant difference in spread ratio compared to whole wheat cookies (191)
Malted whole wheat/malted coarse grain (barley, sorghum, pearl millet) blend/defatted soy flour50:40:10-Enhanced functional properties (192)
Whole wheat/pearl millet flour40:60Increased fat, fibre, iron, calcium and phosphorus contentSignificantly reduced mass, diameter and spread factor.
Improved hardness, chewiness, gumminess, breaking and cutting strength
(46)
Whole wheat/cladode flour75:25Increased total phenolic content
Enhanced radical scavenging activity
No significant difference in mass, diameter and hardness
Significant difference in thickness and spread ratio
(193)
Whole wheat/date seed powder92.5:7.5Enhanced total phenolic content, flavonoids and antioxidant capacityEnhanced crispiness (158)
Whole wheat/tomato powder98:2Enhanced antioxidant activity, reducing power, total carotenoid and total phenolic content
increased ash and fat content
Better rising ability of cookies due to reduced spread ratio (179)
Whole wheat/crude lycopene99.9:0.1
Whole wheat/germinated pumpkin seed flour70:30Increased ash, protein, fat, mineral (i.e. calcium, magnesium iron and zinc) and total dietary fibre (i.e. soluble and insoluble) contentReduced diameter and thickness
Increased spread ratio
(194)
Whole wheat/germinated fenugreek seed flour/oats70:10:20Increased protein, crude fibre, fat, ash, mineral (i.e. calcium, magnesium, zinc and iron) and energy content
Reduced carbohydrate content
Moderately increased anti-nutrient content including phytic acid and condensed tannins
Reduced spread ratio and crispiness
Improved mass
(140)
Whole wheat/saffron99:1Enhanced resistant starch content, total phenolic and DPPH radical scavenging activityImproved lightness, hardness and spread factor (147)
Whole wheat/quinoa seed flour60:40Nutritionally acceptable ratio due to presence of the highest protein, fibre and ash contents
Reduced carbohydrate and fat content
Improved spread ratio Reduced width and diameter (66)
90:10Organoleptically highest acceptable ratio
Increased protein, fibre and ash content compared to 100 % whole wheat biscuits
Reduced spread ratio and diameter
Improved width
Whole wheat/avocado peel95:5Increased protein, fibre, ash (i.e. potassium, calcium, sodium, magnesium and iron)Enhanced crispiness (168)
Whole wheat/amaranth/nopal/oyster mushroom50: 30:15:5Increased ash, fibre and protein
Enhanced total phenolic, total flavonoid content and antioxidant activity
No adverse effect on sensorial attributes (115)
NoodlesWhole wheat/sorghum/chia seed--Improved cooking qualities, water absorption capacity and mass of the noodles
Reduced cooking losses
(195)
Whole wheat/unripe banana flour55:45Increased fibre, and resistant starch contentReduced cooking time
Improved water absorption and rehydration ratio
(196)
Whole wheat/foxtail millet/mushroom/rice bran40:50:5:5Increased ash, protein, fat and fibre content
Reduced carbohydrate content
Improved amino acid profile
Excellent source of calcium, iron and phosphorous
Improved organoleptic properties including flavour and taste (197)
Whole wheat/potato peel flour60:40Possess considerable amount of energy
Improved nutritive value
Optimum ratio for 3D printed noodles with the adequate strength to withstand post-processing steps, better pasting properties, flowability and printability
Acceptable sensory properties.
Cooking quality and textural properties comparable to the commercial product
(198)
Whole wheat/oat flour70:30-Improved hardness and chewiness
Increase in hardness of noodles with the increasing dough sheet thickness.
Reduced cooking time
Decrease in cooking time with the reduced thickness of the noodle
(56)
PastaWhole wheat/bambara groundnut80:20Increased fat, protein, ash contents and reduced carbohydrate and fibre content with the reduction of particle size
Reduced total phenolic content and increased antioxidant activitiy in fractionated flour pasta with the reduction of particle size
Increased optimum cooking time with reduced particle size
Comparatively higher scorings for sensory attributes in terms of colour, taste, mouthfeel and overall acceptability of fractionated flour pasta with finer particles
(180)
Cakes/
muffins
Whole wheat/sweet potato/pigeon pea70:10:20Increased fibre, protein and ash (i.e. Ca, P and K) content
Reduced fat content
Increased tannin and trypsin inhibitor
Reduced phytate content
Organoleptically comparable with the whole wheat cakes (102)
Whole wheat/ungerminated flaxseed85:15Increased protein, ash and fibre contentImproved softness
Reduced mass and volume
(148)
Whole wheat/germinated
flaxseed
90:10

BIOAVAILABILITY AND BIOACCESSIBILITY STUDIES OF WHOLE WHEAT-BASED FUNCTIONAL FOODS

There is a growing trend of consumer preference for native food components and natural products over synthetic compounds to achieve the desired health benefits through a regular diet (199). Despite the presence of numerous bioactive molecules in foods, the consumption of these foods is not necessarily associated with favourable health effects (200). Furthermore, not all bioactive substances are utilized efficiently by the organisms (199). Therefore, studies to evaluate the bioactivity of functional foods and their nutritional efficacy are essential (199,200). Factors affecting the efficacy of bioactive compounds in foods include their steadiness in the food matrix, bioavailability, metabolomics and nutrigenomics. The crucial characteristic of any food formulation is the bioavailability of its nutrients (199). From nutritional point of view, bioavailability is defined as the proportion of a nutrient that is available either for physiological activities or storage. First, a food component must be released from the food matrix and digested to become available. For this reason, bioaccessibility is the preliminary step of bioavailability. It is defined as the amount of nutrients released from the food matrix into the gastrointestinal tract and enter the bloodstream in a suitable form for absorption (199,200). Bioavailability and bioaccessibility studies of whole wheat-based functional foods are listed inTable 2 (47,82,93,141,147,151,201-209).

Table 2 Bioavailability and bioaccessibility studies on whole wheat-based functional foods
ProductComposite flourStudy typeOutcomeRef.
BreadWhole wheat/green coffeeIn vitroIncreased bioaccessibility of phenolic compounds compared to control whole wheat bread (201)
Whole wheat/quinoaIn vivoReduced triglyceride, total cholesterol, low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) levels
Reduced GI (42.0) compared to control (69.20)
(202)
Whole wheat/amaranth/achaIn vitroEnhanced metal chelating and radical scavenging ability
Higher α-amylase and α-glucosidase inhibitory activity
Reduced GI
(203)
Whole wheat/acha/ pigeon pea/date palm fruit sugarIn vivoReduced GI
Reduced postprandial blood glucose response
(93)
Whole wheat/chickpeaIn vivoReduced glycaemic response (82)
Whole wheat/quinoa/
chia/amaranth
In vitroReduced GI (85.0) compared to control (95.0)
Reduced protein digestibility
Increased nutritional index
(151)
FlatbreadWhole wheat/moringa/
C4H2FeO4
In vitroHigher mass ratio of bioaccessible iron and calcium (2.75 and 50.09 mg/100 g) than control (0.16 and 53.0 mg/100 g)
Higher mass ratio of bioaccessible carotene and β-carotene (0.203 mg/100 g and 183.04 µg/100 g) than control [not detected (ND)]
(204)
Whole wheat/
moringa/FeSO4
Higher mass ratio of bioaccessible iron and calcium (2.54 and 47.19 mg/100 g) than control (0.16 and 53.0 mg/100 g)
Higher mass ratio of bioaccessible carotene and β-carotene (0.226 mg/100 g and 190.86 µg/100 g) than control (ND)
Whole wheat/
amaranth leaves/
C4H2FeO4
Higher mass ratio of bioaccessible iron and calcium (3.77 and 71.39 mg/100 g) than control (0.16 and 53.0 mg/100 g)
Higher mass ratio of bioaccessible carotene and β-carotene (0.157 mg/100 g and 158.91 µg/100 g) than control (ND)
Whole wheat/
amaranth leaves/
FeSO4
Higher mass ratio of bioaccessible iron and calcium (3.87 and 75.0 mg/100 g) than control (0.16 and 53.0 mg/100 g)
Higher mass ratio of bioaccessible carotene and β-carotene (0.150 mg/100 g and 156.28 µg/100 g) than control (ND)
Whole wheat/
chickpea/FeSO4
Higher mass ratio of bioaccessible iron (3.39 mg/100 g) than control (0.16 mg/100 g)
Whole wheat/
chickpea/C4H2FeO4
Higher mass ratio of bioaccessible iron (2.16 mg/100 g) than control (0.16 mg/100 g)
Whole wheat/green gram/FeSO4Higher mass ratio of bioaccessible iron and calcium (3.38 and 81.47 mg/100 g) than control (0.16 and 53.0 mg/100 g)
Whole wheat/green gram/C4H2FeO4Higher mass ratio of bioaccessible iron and calcium (2.43 and 81.14 mg/100 g) than control (0.16 and 53.0 mg/100 g)
Whole wheat/buckwheatIn vitroIncreased in vitro protein digestibility from 78 to 88 % with the addition of buckwheat flour (205)
Whole wheat/spices (ajwain/ cumin/cardamom/ fennel/cinnamon/ginger/black pepper)In vitroEnhanced protein digestibility
Increased bioaccessibility of iron and zinc
(141)
Whole wheat/pigeon peaIn vitroReduced slowly digestible starch and increased resistant starch content
Reduced starch digestibility
Reduced predicted glycaemic index
High protein digestibility
(206)
Whole wheat/fenugreekIn vitroReduced starch digestibility (27.12 %) compared to control (37.87 %)
Reduced protein digestibility (83.56 %) compared to control (68.18 %)
(207)
Whole wheat/sorghum/pearl milletIn vivoReduced GI (25.40) compared to control (40.40)
Showed hypoglycaemic effects
(47)
Biscuits/cookiesWhole wheat/sorghum/pearl milletIn vivoReduced GI (27.50) compared to control (44.28)
Hypoglycaemic effects
(47)
Whole wheat/wheat germ/coffee silver skinIn vitroIncreased phenolic bioaccessibility compared to control whole wheat cookies
Increased antioxidant bioaccessibility of cookies compared to control
(208)
Whole wheat/saffronIn vitroIncreased resistant starch content
Reduced starch digestibility
(147)
Whole wheat/buckthorn
BagelsWhole wheat/banana peel/lavenderIn vivoReduced anxiety score among participants
Anxiolytic potential
(209)

CONCLUSIONS

Composite flour technology plays a vital role in improving the economic status of a country by saving the foreign exchange provided for wheat import and promoting the local agriculture by using indigenous crops, which increases rural employment and income. Partial substitution of wheat flour is the most feasible approach of the composite flour technology because it can complement the nutritional profile of wheat. Recently, consumer interest in non-wheat flour has increased due to its ability to ameliorate non-communicable diseases, which is due to the presence of macronutrients, micronutrients and phytochemicals in significant amounts. The results of research studies have shown that the deficiency in micro- and certain macronutrients can be eliminated by the objectively formulated composite flour-based products. The inclusion of leafy, non-leafy vegetables, roots and tubers along with fruits in the composite flour formulations is expected to provide numerous nutritional benefits. The phytochemicals available in these sources not only have a positive effect on health, but also improve the physicochemical properties of the final product. When the components with different properties are combined together in the formulation of composite flour, the rheological properties of the dough are improved in different ways. Since most of the aforementioned substances are underutilised or unidentified as highly nutritious sources, the use of these materials in composite flour formulations leads to a reduction in the cost of flatbread and other bakery products, thus ensuring the country’s national food security. The use of composite flours in the food industry has paved the way for the formulation of products with significant nutritional, organoleptic and therapeutic properties. The appropriate quality and quantity of flour combinations can be determined according to product technology, consumer requirements and acceptance. However, there is still much room for scientific research to evaluate the process modifications, novel methods and additional sources that can optimise the quality of the composite flour products. This will lead to the popularisation of the composite flour products and capturing a significant market in the near future due to their economic value, health benefits and nutritional properties.

ACKNOWLEDGEMENT

Authors acknowledge the help of the Research council, University of Sri Jayewardenepura, Sri Lanka.

Notes

[1] Financial disclosure FUNDING

This work was conducted under the research grant (number: ASP/01/RE/SCI/2021/18) offered by the University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.

[2] Conflicts of interest CONFLICT OF INTEREST

Authors declare no conflict of interest.

REFERENCES

1 

González-Esteban ÁL. Why wheat? International patterns of wheat demand, 1939–2010. Investig Hist Econ. 2017;13(3):135–50. https://doi.org/10.1016/j.ihe.2017.06.001

2 

Abdullah MM, Aldughpassi AD, Sidhu JS, Al-Foudari MY, Al-Othman AR. Effect of psyllium husk addition on the instrumental texture and consumer acceptability of high-fiber wheat pan bread and buns. Ann Agric Sci. 2021;66(1):75–80. https://doi.org/10.1016/j.aoas.2021.05.002

3 

Chikpah SK, Korese JK, Hensel O, Sturm B, Pawelzik E. Rheological properties of dough and bread quality characteristics as influenced by the proportion of wheat flour substitution with orange-fleshed sweet potato flour and baking conditions. LWT – Food Sci Technol. 2021;147:111515. https://doi.org/10.1016/j.lwt.2021.111515

4 

Dapčević-Hadnađev T, Tomić J, Škrobot D, Šarić B, Hadnađev M. Processing strategies to improve the breadmaking potential of whole-grain wheat and non-wheat flours. Discov Food. 2022;2(1):11. https://doi.org/10.1007/s44187-022-00012-w

5 

Nasabi M, Naderi B, Akbari M, Aktar T, Kieliszek M, Amini M. Physical, structural and sensory properties of wafer batter and wafer sheets influenced by various sources of grains. LWT – Food Sci Technol. 2021;149:111826. https://doi.org/10.1016/j.lwt.2021.111826

6 

Bajka BH, Pinto AM, Ahn-Jarvis J, Ryden P, Perez-Moral N, van der Schoot A, et al. The impact of replacing wheat flour with cellular legume powder on starch bioaccessibility, glycaemic response and bread roll quality: A double-blind randomised controlled trial in healthy participants. Food Hydrocoll. 2021;114:106565. https://doi.org/10.1016/j.foodhyd.2020.106565 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33941996

7 

Sharma N, Bhatia S, Chunduri V, Kaur S, Sharma S, Kapoor P, et al. Pathogenesis of celiac disease and other gluten related disorders in wheat and strategies for mitigating them. Front Nutr. 2020;7:6. https://doi.org/10.3389/fnut.2020.00006 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32118025

8 

Rustgi S, Shewry P, Brouns F. Health hazards associated with wheat and gluten consumption in susceptible individuals and status of research on dietary therapies. In: Igrejas G, Ikeda T, Guzmán C, editors. Wheat quality for improving processing and human health. Cham, Switzerland: Springer; 2020. pp. 471-515. https://doi.org/10.1007/978-3-030-34163-3_20 https://doi.org/10.1007/978-3-030-34163-3_20

9 

Caeiro C, Pragosa C, Cruz MC, Pereira CD, Pereira SG. The role of pseudocereals in celiac disease: Reducing nutritional deficiencies to improve well‐being and health. J Nutr Metab. 2022;2022(1):8502169. https://doi.org/10.1155/2022/8502169 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35186332

10 

Wieser H, Koehler P, Scherf KA. The two faces of wheat. Front Nutr. 2020;7:517313. https://doi.org/10.3389/fnut.2020.517313 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33195360

11 

Singh N, Singh D, Daynauth R, Dalrymple N, Persaud R, Persaud B. Physical and sensory properties of bread and roti made from rice-wheat composite flour. Eur J Agric Food Sci. 2023;5(4):41–6. https://doi.org/10.24018/ejfood.2023.5.4.712

12 

Ibidapo OP, Henshaw FO, Shittu TA, Afolabi WA. Quality evaluation of functional bread developed from wheat, malted millet (Pennisetum Glaucum) and ‘Okara’ flour blends. Sci Afr. 2020;10:e00622. https://doi.org/10.1016/j.sciaf.2020.e00622

13 

Gómez M, Gutkoski LC, Bravo‐Núñez Á. Understanding whole‐wheat flour and its effect in breads: A review. Compr Rev Food Sci Food Saf. 2020;19(6):3241–65. https://doi.org/10.1111/1541-4337.12625 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33337058

14 

Adeniji TA. Review of cassava and wheat flour composite in bread making: Prospects for industrial application. Afr J Plant Sci Biotechnol. 2013;7(1):1–8.

15 

Engindeniz S, Bolatova Z. A study on consumption of composite flour and bread in global perspective. Br Food J. 2021;123(5):1962–73. https://doi.org/10.1108/BFJ-10-2018-0714

16 

Chandra S, Singh S, Kumari D. Evaluation of functional properties of composite flours and sensorial attributes of composite flour biscuits. J Food Sci Technol. 2015;52:3681–8. https://doi.org/10.1007/s13197-014-1427-2 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/26028751

17 

Torbica A, Belović M, Popović L, Čakarević J. Heat and hydrothermal treatments of non-wheat flours. Food Chem. 2021;334:127523. https://doi.org/10.1016/j.foodchem.2020.127523 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32721833

18 

Ginindza A, Solomon WK, Shelembe JS, Nkambule TP. Valorisation of brewer’s spent grain flour (BSGF) through wheat-maize-BSGF composite flour bread: Optimization using d-optimal mixture design. Heliyon. 2022;8(6):e09514. https://doi.org/10.1016/j.heliyon.2022.e09514 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35663457

19 

Gujral HS, Sharma B, Singh P. Utilization of flour from rice brokens in wheat flour chapatti: Evaluation of dough rheology, starch digestibility, glycemic index and retrogradation behavior. J Food Sci Technol. 2019;56:2490–500. https://doi.org/10.1007/s13197-019-03726-5 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31168131

20 

Tian S, Wei Y, Chen Z. Effect of mixture design approach on nutritional characteristics and sensory evaluation of steamed bread added rice flour. Front Nutr. 2022;9:989090. https://doi.org/10.3389/fnut.2022.989090 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36438756

21 

Kalaivani R, Bakiyalakshmi SV, Nandhini R. An integrated approach on study of nutritional and in vitro anti cancerous properties of traditional pigmented rices against MCF7 cell line. J Nat Rem. 2020;21(8):205–15.

22 

Haldipur AC, Srividya N. Multi-mechanistic in vitro evaluation of antihyperglycemic, antioxidant and antiglycation activities of three phenolic-rich Indian red rice genotypes and in silico evaluation of their phenolic metabolites. Foods. 2021;10(11):2818. https://doi.org/10.3390/foods10112818 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34829098

23 

Suwannasom N, Thepmalee C, Khoothiam K, Thephinlap C. Evaluation of anti-hyperglycemia and complications of red and black Thai jasmine rice cultivars in streptozotocin-induced diabetic rats. Molecules. 2022;27(22):8043. https://doi.org/10.3390/molecules27228043 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36432144

24 

Verma DK, Srivastav PP. Bioactive compounds of rice (Oryza sativa L.): Review on paradigm and its potential benefit in human health. Trends Food Sci Technol. 2020;97:355–65. https://doi.org/10.1016/j.tifs.2020.01.007

25 

Piazza S, Colombo F, Bani C, Fumagalli M, Vincentini O, Sangiovanni E, et al. Evaluation of the potential anti-inflammatory activity of black rice in the framework of celiac disease. Foods. 2022;12(1):63. https://doi.org/10.3390/foods12010063 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36613279

26 

Erenstein O, Jaleta M, Sonder K, Mottaleb K, Prasanna BM. Global maize production, consumption and trade: Trends and R&D implications. Food Secur. 2022;14(5):1295–319. https://doi.org/10.1007/s12571-022-01288-7

27 

Bello-Pérez LA, Flores-Silva PC, Sifuentes-Nieves I, Agama-Acevedo E. Controlling starch digestibility and glycaemic response in maize-based foods. J Cereal Sci. 2021;99:103222. https://doi.org/10.1016/j.jcs.2021.103222

28 

Ajifolokun OM, Basson AK, Osunsanmi FO, Zharare GE. Nutritional composition and organoleptic properties of composite maize porridge. J Food Process Technol. 2019;10(6):1000798. https://doi.org/10.4172/2157-7110.1000798

29 

Bekkering CS, Tian L. Thinking outside of the cereal box: Breeding underutilized (pseudo) cereals for improved human nutrition. Front Genet. 2019;10:1289. https://doi.org/10.3389/fgene.2019.01289 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31921317

30 

Wang Y, Jian C. Sustainable plant-based ingredients as wheat flour substitutes in bread making. NPJ Sci Food. 2022;6(1):49. https://doi.org/10.1038/s41538-022-00163-1 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36307422

31 

Chakraborty R, Kalita P, Sen S. Phenolic profile, antioxidant, antihyperlipidemic and cardiac risk preventive effect of pigmented black rice variety Chakhao poireiton in high-fat high-sugar induced rats. Rice Sci. 2023;30(6):641–51. https://doi.org/10.1016/j.rsci.2023.08.002

32 

Al-Okbi SY, Hamed TE, Elewa TA, Ramadan AA, El-Karamany MF, Bakry BA. Role of polar extracts from two quinoa varieties in prevention of steatohepatitis and cardiovascular diseases and improving glucose tolerance in rats. J Herbmed Pharmacol. 2020;10(1):93–101. https://doi.org/10.34172/jhp.2021.09

33 

Wolever TMS, Rahn M, Dioum E, Spruill SE, Ezatagha A, Campbell JE, et al. An oat β-glucan beverage reduces LDL cholesterol and cardiovascular disease risk in men and women with borderline high cholesterol: A double-blind, randomized, controlled clinical trial. J Nutr. 2021;151(9):2655–66. https://doi.org/10.1093/jn/nxab154 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34236436

34 

Keenan JM, Goulson M, Shamliyan T, Knutson N, Kolberg L, Curry L. The effects of concentrated barley β-glucan on blood lipids in a population of hypercholesterolaemic men and women. Br J Nutr. 2007;97(6):1162–8. https://doi.org/10.1017/S0007114507682968 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/17445284

35 

Sofi F, Ghiselli L, Dinu MR, Whittaker A, Pagliai G, Cesari F, et al. Consumption of buckwheat products and cardiovascular risk profile: A randomized, single-blinded crossover trial. J Nutr Food Sci. 2016;6(3):1000501. https://doi.org/10.4172/2155-9600.1000501

36 

Guo H, Wu H, Sajid A, Li Z. Whole grain cereals: The potential roles of functional components in human health. Crit Rev Food Sci Nutr. 2022;62(30):8388–402. https://doi.org/10.1080/10408398.2021.1928596 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34014123

37 

Azam A, Itrat N, Ahmed U. Hypoglycemic effect of barley (Hordeum vulgare) in diabetics. Int J Innov Sci Res Technol. 2019;4(5):515–9.

38 

Lopes CO, Barcelos MD, Vieira CN, de Abreu WC, Ferreira EB, Pereira RC, et al. Effects of sprouted and fermented quinoa (Chenopodium quinoa) on glycemic index of diet and biochemical parameters of blood of Wistar rats fed high carbohydrate diet. J Food Sci Technol. 2019;56:40–8. https://doi.org/10.1007/s13197-018-3436-z PubMed: http://www.ncbi.nlm.nih.gov/pubmed/30728545

39 

Paśko P, Tyszka-Czochara M, Namieśnik J, Jastrzębski Z, Leontowicz H, Drzewiecki J, et al. Cytotoxic, antioxidant and binding properties of polyphenols from the selected gluten-free pseudocereals and their by-products: In vitro model. J Cereal Sci. 2019;87:325–33. https://doi.org/10.1016/j.jcs.2019.04.009

40 

Rao S, Chinkwo K, Santhakumar A, Johnson S, Blanchard C. Apoptosis induction pathway in human colorectal cancer cell line SW480 exposed to cereal phenolic extracts. Molecules. 2019;24(13):2465. https://doi.org/10.3390/molecules24132465 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31277499

41 

Mathews R, Shete V, Chu Y. The effect of cereal B‐glucan on body weight and adiposity: A review of efficacy and mechanism of action. Crit Rev Food Sci Nutr. 2023;63(19):3838–50. https://doi.org/10.1080/10408398.2021.1994523 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34727805

42 

Wu S, Jia W, He H, Yin J, Xu H, He C, et al. A new dietary fiber can enhance satiety and reduce postprandial blood glucose in healthy adults: A randomized cross-over trial. Nutrients. 2023;15(21):4569. https://doi.org/10.3390/nu15214569 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37960222

43 

Hong S, Pangloli P, Perumal R, Cox S, Noronha LE, Dia VP, et al. A comparative study on phenolic content, antioxidant activity and anti-inflammatory capacity of aqueous and ethanolic extracts of sorghum in lipopolysaccharide-induced RAW 264.7 macrophages. Antioxidants. 2020;9(12):1297. https://doi.org/10.3390/antiox9121297 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33353009

44 

Liu M, Zhu K, Yao Y, Chen Y, Guo H, Ren G, et al. Antioxidant, anti‐inflammatory, and antitumor activities of phenolic compounds from white, red, and black Chenopodium quinoa seed. Cereal Chem. 2020;97(3):703–13. https://doi.org/10.1002/cche.10286

45 

Compaore-Sereme D, Hama-Ba F, Tapsoba FW, Manner H, Maina NH, Dicko MH, et al. Production and sensory evaluation of composite breads based on wheat and whole millet or sorghum in the presence of Weissella confusa A16 exopolysaccharides. Heliyon. 2023;9(3):e13837. https://doi.org/10.1016/j.heliyon.2023.e13837 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36915561

46 

Kulkarni DB, Sakhale BK, Chavan RF. Studies on development of low gluten cookies from pearl millet and wheat flour. Food Res. 2021;5(4):114–9. https://doi.org/10.26656/fr.2017.5(4).028

47 

Bindra D, Manju D. Formulation and evaluation of foods from composite flour blends of sorghum, pearl millet and whole wheat for suitability in diabetic diet. Int J Home Sci. 2019;5(3):220–9.

48 

Vedamanickam R, Anandan P, Bupesh G, Vasanth S. Study of millet and non-millet diet on diabetics and associated metabolic syndrome. Biomedicine (Taipei). 2020;40(1):55–8. https://doi.org/10.1016/j.jtcme.2020.01.003

49 

Chung IM, Yeo MA, Kim SJ, Kim MJ, Park DS, Moon HI. Antilipidemic activity of organic solvent extract from Sorghum bicolor on rats with diet-induced obesity. Hum Exp Toxicol. 2011;30(11):1865–8. https://doi.org/10.1177/0960327110390066 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/21078773

50 

Chaudhary JK, Mudgal S. Antidiabetic and hypolipidaemic action of finger millet (Eleusine coracana)-enriched probiotic fermented milk: An in vivo rat study. Food Technol Biotechnol. 2020;58(2):192. https://doi.org/10.17113/ftb.58.02.20.6308 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32831571

51 

Lee HS, Santana ÁL, Peterson J, Yucel U, Perumal R, De Leon J, et al. Anti-adipogenic activity of high-phenolic sorghum brans in pre-adipocytes. Nutrients. 2022;14(7):1493. https://doi.org/10.3390/nu14071493 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35406112

52 

Khare P, Maurya R, Bhatia R, Mangal P, Singh J, Podili K, et al. Polyphenol rich extracts of finger millet and kodo millet ameliorate high fat diet-induced metabolic alterations. Food Funct. 2020;11(11):9833–47. https://doi.org/10.1039/D0FO01643H PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33089852

53 

Hunegnaw Z, Gelayee DA, Sabe ZS. In vivo antidiarrheal activity evaluation of the seeds of Sorghum bicolor L. (Poaceae). Discov Phytomed. 2016;3(4):22. https://doi.org/10.15562/phytomedicine.2016.36

54 

Lin HC, Sheu SY, Sheen LY, Sheu PW, Chiang W, Kuo TF. The gastroprotective effect of the foxtail millet and adlay processing product against stress-induced gastric mucosal lesions in rats. J Tradit Complement Med. 2020;10(4):336–44. https://doi.org/10.1016/j.jtcme.2020.01.003 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32695650

55 

Mansoor R, Ali TM, Arif S, Moin A, Hasnain A. Effects of barley flour on dough rheology, texture, sensory and glycemic index of traditional unleavened flat bread (Roti). Cereal Chem. 2019;96(6):1170–9. https://doi.org/10.1002/cche.10228

56 

Shi Z, Liu L, Zhang K, Wang X, Ma Z, Ren T, et al. Effect of sheeting thickness on the processing quality of wheat-oat blended flour noodles. J Cereal Sci. 2021;99:103223. https://doi.org/10.1016/j.jcs.2021.103223

57 

Abdullah M, Zulkiffal M, Tufail T, Akbar FN, Owais M, Ahmed J, et al. Added value upshot of barley amalgamation in wheat flour to boost the physico-chemical quality attributes of flat bread. Cereal Res Commun. 2023;51:981–9. https://doi.org/10.1007/s42976-023-00357-7

58 

Fuse Y, Higa M, Miyashita N, Fujitani A, Yamashita K, Ichijo T, et al. Effect of high β-glucan barley on postprandial blood glucose and insulin levels in type 2 diabetic patients. Clin Nutr Res. 2020;9(1):43–51. https://doi.org/10.7762/cnr.2020.9.1.43 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32095447

59 

Xu D, Liu H, Yang C, Xia H, Pan D, Yang X, et al. Effects of different delivering matrices of β-glucan on lipids in mildly hypercholesterolaemic individuals: A meta-analysis of randomised controlled trials. Br J Nutr. 2021;125(3):294–307. https://doi.org/10.1017/S0007114520001610 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32378501

60 

Schlörmann W, Atanasov J, Lorkowski S, Dawczynski C, Glei M. Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model. Food Funct. 2020;11(3):2626–38. https://doi.org/10.1039/C9FO03009C PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32176229

61 

Arslan-Tontul S, Candal Uslu C, Mutlu C, Erbaş M. Expected glycemic impact and probiotic stimulating effects of whole grain flours of buckwheat, quinoa, amaranth and chia. J Food Sci Technol. 2022;59:1460–7. https://doi.org/10.1007/s13197-021-05156-8 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35250069

62 

Tomar O, Çağlar A, Akarca G. Quality characteristics of tarhana produced with different ratios of whole wheat and buckwheat flour. Gida. 2020;45(3):421–32. https://doi.org/10.15237/gida.GD19152

63 

Mahmood S, Pasha I, Iqbal MW, Riaz T, Adnan M, Chitrakar B, et al. Rheological and sensory attributes of wheat, quinoa and buckwheat composite flour and their use in bakery products. J Food Sci Technol Nepal. 2019;11:25–31. https://doi.org/10.3126/jfstn.v11i0.29706

64 

Zieliński H, Honke J, Topolska J, Bączek N, Piskuła MK, Wiczkowski W, et al. ACE inhibitory properties and phenolics profile of fermented flours and of baked and digested biscuits from buckwheat. Foods. 2020;9(7):847. https://doi.org/10.3390/foods9070847 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32610526

65 

Gomathi GK, Parameshwari S, Uvaraj MG. In-vivo efficacy of buckwheat flour incorporated food products on the blood glucose and lipid profiles. Biosci Biotechnol Res Asia. 2023;20(2):3112. https://doi.org/10.13005/bbra/3112

66 

Puri S, Sarao LK, Kaur K, Talwar A. Nutritional and quality analysis of quinoa seed flour fortified wheat biscuits. Asian Pac J Health Sci. 2020;7(1):48–52. https://doi.org/10.21276/apjhs.2020.7.1.9

67 

Fan X, Guo H, Teng C, Zhang B, Blecker C, Ren G. Anti-colon cancer activity of novel peptides isolated from in vitro digestion of quinoa protein in Caco-2 cells. Foods. 2022;11(2):194. https://doi.org/10.3390/foods11020194 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35053925

68 

Pourshahidi LK, Caballero E, Osses A, Hyland BW, Ternan NG, Gill CI. Modest improvement in CVD risk markers in older adults following quinoa (Chenopodium quinoa Willd.) consumption: A randomized-controlled crossover study with a novel food product. Eur J Nutr. 2020;59:3313–23. https://doi.org/10.1007/s00394-019-02169-0 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31919583

69 

An T, Liu JX, Yang XY, Lv BH, Wu YX, Jiang GJ. Supplementation of quinoa regulates glycolipid metabolism and endoplasmic reticulum stress in the high-fat diet-induced female obese mice. Nutr Metab (Lond). 2021;18:95. https://doi.org/10.1186/s12986-021-00622-8 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34702298

70 

Song C, Lv W, Li Y, Nie P, Lu J, Geng Y, et al. Alleviating the effect of quinoa and the underlying mechanism on hepatic steatosis in high-fat diet-fed rats. Nutr Metab (Lond). 2021;18:106. https://doi.org/10.1186/s12986-021-00631-7 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34922572

71 

Wang TY, Tao SY, Wu YX, An T, Lv BH, Liu JX, et al. Quinoa reduces high-fat diet-induced obesity in mice via potential microbiota-gut-brain-liver interaction mechanisms. Microbiol Spectr. 2022;10(3):e00329-22. https://doi.org/10.1128/spectrum.00329-22 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35583337

72 

Malik M, Sindhu R, Dhull SB, Bou-Mitri C, Singh Y, Panwar S, et al. Nutritional composition, functionality, and processing technologies for amaranth. J Food Process Preserv. 2023;2023(1):1753029. https://doi.org/10.1155/2023/1753029

73 

Fisayo Ajayi F, Mudgil P, Gan CY, Maqsood S. Identification and characterization of cholesterol esterase and lipase inhibitory peptides from amaranth protein hydrolysates. Food Chem X. 2021;12:100165. https://doi.org/10.1016/j.fochx.2021.100165 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34877527

74 

Kamal H, Mudgil P, Bhaskar B, Fisayo AF, Gan CY, Maqsood S. Amaranth proteins as potential source of bioactive peptides with enhanced inhibition of enzymatic markers linked with hypertension and diabetes. J Cereal Sci. 2021;101:103308. https://doi.org/10.1016/j.jcs.2021.103308

75 

Peter J, Sabu V, Aswathy IS, Krishnan S, Lal Preethi SS, Simon M, et al. Dietary amaranths modulate the immune response via balancing Th1/Th2 and Th17/Treg response in collagen-induced arthritis. Mol Cell Biochem. 2020;472:57–66. https://doi.org/10.1007/s11010-020-03783-x PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32529499

76 

Belc N, Duta DE, Culetu A, Stamatie GD. Type and amount of legume protein concentrate influencing the technological, nutritional, and sensorial properties of wheat bread. Appl Sci (Basel). 2021;11(1):436. https://doi.org/10.3390/app11010436

77 

Carbas B, Machado N, Pathania S, Brites C, Rosa EA, Barros AI. Potential of legumes: Nutritional value, bioactive properties, innovative food products, and application of eco-friendly tools for their assessment. Food Rev Int. 2023;39(1):160–88. https://doi.org/10.1080/87559129.2021.1901292

78 

Goldstein N, Reifen R. The potential of legume-derived proteins in the food industry. Grain Oil Sci Technol. 2022;5(4):167–78. https://doi.org/10.1016/j.gaost.2022.06.002

79 

Zhang Y, Hu R, Tilley M, Siliveru K, Li Y. Effect of pulse type and substitution level on dough rheology and bread quality of whole wheat-based composite flours. Processes (Basel). 2021;9(9):1687. https://doi.org/10.3390/pr9091687

80 

Ribeiro JV, Graziani D, Carvalho JH, Mendonça MM, Naves LM, Oliveira HF, et al. A peptide fraction from hardened common beans (Phaseolus vulgaris) induces endothelium-dependent antihypertensive and renal effects in rats. Curr Res Food Sci. 2023;6:100410. https://doi.org/10.1016/j.crfs.2022.100410 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36545514

81 

Serna-Perez AB, Loarca-Piña G, Luzardo-Ocampo I. Characterization of dietary fiber extracts from corn (Zea mays L.) and cooked common bean (Phaseolus vulgaris L.) flours and evaluation of their inhibitory potential against enzymes associated with glucose and lipids metabolism in vitro. Biol Life Sci Forum. 2021;6(1):86. https://doi.org/10.3390/Foods2021-11049 https://doi.org/10.3390/Foods2021-11049

82 

Zafar TA, Aldughpassi A, Al-Mussallam A, Al-Othman A. Microstructure of whole wheat versus white flour and wheat-chickpea flour blends and dough: Impact on the glycemic response of pan bread. Int J Food Sci. 2020;2020:8834960. https://doi.org/10.1155/2020/8834960 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33083447

83 

Kelly PJ, Furie KL. Management and prevention of stroke associated with elevated homocysteine. Curr Treat Options Cardiovasc Med. 2002;4(5):363–71. https://doi.org/10.1007/s11936-002-0016-2 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/12194809

84 

Gemede HF, Ratta N. Antinutritional factors in plant foods: Potential health benefits and adverse effects. Int J Nutr Food Sci. 2014;3(4):284–9. https://doi.org/10.11648/j.ijnfs.20140304.18

85 

Gómez-Zorita S, González-Arceo M, Fernández-Quintela A, Eseberri I, Trepiana J, Portillo MP. Scientific evidence supporting the beneficial effects of isoflavones on human health. Nutrients. 2020;12(12):3853. https://doi.org/10.3390/nu12123853 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33348600

86 

Angeles JG, Villanueva JC, Uy LY, Mercado SM, Tsuchiya MC, Lado JP, et al. Legumes as functional food for cardiovascular disease. Appl Sci (Basel). 2021;11(12):5475. https://doi.org/10.3390/app11125475

87 

Fuel M, Mesas C, Martínez R, Ortiz R, Quiñonero F, Bermúdez F, et al. Antioxidant and chemopreventive activity of protein hydrolysates from raw and germinated flour of legumes with commercial interest in colorectal cancer. Antioxidants. 2022;11(12):2421. https://doi.org/10.3390/antiox11122421 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36552629

88 

Patel L, La Vecchia C, Negri E, Mignozzi S, Augustin LS, Levi F, et al. Legume intake and cancer risk in a network of case-control studies. Eur J Clin Nutr [Preprint]. 2024. https://doi.org/10.21203/rs.3.rs-2398023/v1

89 

Anosike FC, Chinwendu OR, Nnaemeka NA, Nneka MG, Inyang P, Ikechukwu C, et al. Evaluation of baking qualities, functional and physicochemical properties of wheat supplemented with cassava and mung bean flour blends for bread making. Food Bioeng. 2023;2(3):264–72. https://doi.org/10.1002/fbe2.12060

90 

Gomes MJ, Lima SL, Alves NE, Assis A, Moreira ME, Toledo RC, et al. Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet. Nutr Metab Cardiovasc Dis. 2020;30(1):141–50. https://doi.org/10.1016/j.numecd.2019.07.020 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31757569

91 

Shi Z, Zhang X, Zhu Y, Yao Y, Ren G. Natural extracts from white common bean (Phaseolus vulgaris L.) inhibit 3T3-L1 adipocytes differentiation. Appl Sci (Basel). 2020;11(1):167. https://doi.org/10.3390/app11010167

92 

Melese AD, Keyata EO. Effects of blending ratios and baking temperature on physicochemical properties and sensory acceptability of biscuits prepared from pumpkin, common bean, and wheat composite flour. Heliyon. 2022;8(10):e10848. https://doi.org/10.1016/j.heliyon.2022.e10848 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36247146

93 

Olagunju AI. Influence of whole wheat flour substitution and sugar replacement with natural sweetener on nutritional composition and glycaemic properties of multigrain bread. Prev Nutr Food Sci. 2019;24(4):456. https://doi.org/10.3746/pnf.2019.24.4.456 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31915642

94 

Joshi H, Awasthi P. Evaluation of physical properties and sensory attributes of biscuits developed from whole wheat flour supplemented with horse gram flour. J Pharmacogn Phytochem. 2020;9(5):1652–6.

95 

Panda VS, Shah T. A herbal premix containing Macrotyloma uniflorum, ginger, and whey curtails obesity in rats fed a high-fat diet by a novel mechanism. Appl Physiol Nutr Metab. 2020;45(1):24–34. https://doi.org/10.1139/apnm-2019-0139 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31084576

96 

Sudha S, Saral AM. Studies on phytochemical, mineral content, in vitro anti-urolithiatic and anti-diabetic activities of horse gram flour extracts and its biosynthesized Ag nanoparticles. Heliyon. 2023;9(6):e16572. https://doi.org/10.1016/j.heliyon.2023.e16572 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37274714

97 

Malarvizhi R, Mani S, Sali VK, Nithya P, Sekar V, Vasanthi HR. Plausible influence of atorvastatin and dietary legumes (horsegram and groundnut) in dyslipidemia in experimental rodents. Phytomed Plus. 2021;1(2):100032. https://doi.org/10.1016/j.phyplu.2021.100032

98 

Forwoukeh VH, Amove J, Yusufu MI. Characteristics of whole wheat, red kidney bean and defatted coconut flour blends and its application in bread production. Asian Food Sci J. 2023;22(9):23–39. https://doi.org/10.9734/afsj/2023/v22i9655

99 

Nanbol KK, Namo O. The contribution of root and tuber crops to food security: A review. J Agric Sci Technol B. 2019;9(4):221–33. https://doi.org/10.17265/2161-6264/2019.04.001

100 

Sampson GO. Assessing consumer acceptability of composite cassava (Manihot esculenta) bread. Food Nutr Sci. 2020;11(11):990–1002. https://doi.org/10.4236/fns.2020.1111070

101 

Sanni TA, Gbolagade OH, Ogunbusola EM, Araoye KT. Quality assessment of cookies made from composite flour of wheat, sorrel seed protein isolate and yellow cassava flours. J Microbiol Biotechnol Food Sci. 2020;9(6):1073–9. https://doi.org/10.15414/jmbfs.2020.9.6.1073-1079

102 

Olatunde SJ, Ajayi OM, Ogunlakin GO, Ajala AS. Nutritional and sensory properties of cake made from blends of pigeon pea, sweet potato and wheat flours. Food Res. 2019;3(5):456–62. https://doi.org/10.26656/fr.2017.3(5).255

103 

Parveen A, Choi S, Kang JH, Oh SH, Kim SY. Trifostigmanoside I, an active compound from sweet potato, restores the activity of MUC2 and protects the tight junctions through PKCα/β to maintain intestinal barrier function. Int J Mol Sci. 2020;22(1):291. https://doi.org/10.3390/ijms22010291 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33396633

104 

Ogbodo UC, Onyewuchi KC, Mbachu NA, Ezekwesili CN, Okafor CS. Anti-diabetic effects of the aqueous and ethanol extracts of Ipomoea batatas tubers on alloxan induced diabetes in Wistar albino rats. Int J Biochem Res Rev. 2021;30(10):1–3. https://doi.org/10.9734/ijbcrr/2021/v30i1030291

105 

Ginting O, Julianti E, Nainggolan RJ. Hypocholesterolemic effect of biscuit made from purple sweet potato flour, starch, and fiber rich flour on rats. Adv Biol Res (Faisalabad). 2022;16:302–9. https://doi.org/10.2991/absr.k.220101.041

106 

Antarkar S, Gabel S, Tiwari S, Mahajan S, Azmi RM. Evaluation of nutritional and functional properties of partially substituted whole wheat flour with taro root and lotus seed flour (composite flour). Pharma Innov. 2019;8(10):125–8.

107 

Orhevba BA, Ndanaimi Y. Proximate and sensory properties of wheat-cocoyam (Colocasia esculenta) composite bread. Eur J Agric Food Sci. 2021;3(3):86–90. https://doi.org/10.24018/ejfood.2021.3.3.297

108 

Dhillon B, Kaur K, Sodhi NS, Garg R. Physicochemical, antioxidant and microbial properties of whole wheat breads formulated with the incorporation of vegetable paste. J Food Meas Charact. 2021;15:1068–74. https://doi.org/10.1007/s11694-020-00708-6

109 

Wallace TC, Bailey RL, Blumberg JB, Burton-Freeman B, Chen CO, Crowe-White KM, et al. Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake. Crit Rev Food Sci Nutr. 2020;60(13):2174–211. https://doi.org/10.1080/10408398.2019.1632258 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31267783

110 

Alam MK. A comprehensive review of sweet potato (Ipomoea batatas [L.] Lam): Revisiting the associated health benefits. Trends Food Sci Technol. 2021;115:512–29. https://doi.org/10.1016/j.tifs.2021.07.001

111 

Sarkar T, Salauddin M, Roy S, Chakraborty R, Rebezov M, Shariati MA, et al. Underutilized green leafy vegetables: Frontier in fortified food development and nutrition. Crit Rev Food Sci Nutr. 2023;63(33):11679–733. https://doi.org/10.1080/10408398.2022.2095555 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35816152

112 

Singh N, Yadav SS. A review on health benefits of phenolics derived from dietary spices. Curr Res Food Sci. 2022;5:1508–23. https://doi.org/10.1016/j.crfs.2022.09.009 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36132490

113 

Arackal JJ, Parameshwari S. Identification of antioxidant activity and shelf life assay of avocado fruit pulp incorporated chapattis. Mater Today Proc. 2021;45:2589–94. https://doi.org/10.1016/j.matpr.2020.11.337

114 

Pereira AP, Clerici MT, Schmiele M, Pastore GM. Blackberries (Rubus sp.) and whole grain wheat flour in cookies: Evaluation of phenolic compounds and technological properties. J Food Sci Technol. 2019;56(3):1445–53. https://doi.org/10.1007/s13197-019-03628-6 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/30956324

115 

Uriarte-Frías G, Hernández-Ortega MM, Gutiérrez-Salmeán G, Santiago-Ortiz MM, Morris-Quevedo HJ, Meneses-Mayo M. Pre-hispanic foods oyster mushroom (Pleurotus ostreatus), nopal (Opuntia ficus-indica) and amaranth (Amaranthus sp.) as new alternative ingredients for developing functional cookies. J Fungi (Basel). 2021;7(11):911. https://doi.org/10.3390/jof7110911 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34829200

116 

Fakoya S, Adegbehingbe KT, Ademakinwa IS. Bio-therapeutic, phytochemical screening and antioxidant efficacies of oyster mushroom (Pleurotus ostreatus) obtained from the wild. Open J Med Microbiol. 2020;10(2):58–70. https://doi.org/10.4236/ojmm.2020.102006

117 

Akyüz M, İnci Ş, Kırbağ S. Evaluation of antimicrobial, antioxidant, cytotoxic and DNA protective effects of oyster mushroom: Pleurotus pulmonarius (Fr.) Quel. Arab J Sci Eng. 2023;48(6):7273–83. https://doi.org/10.1007/s13369-022-07418-9

118 

Dhillon GK, Mahajan M. Enhancing nutritional quality of unleavened wheat flatbread using oyster mushroom flour: Elevating wheat flatbread’s nutritional profile with mushroom flour. Mushroom Res. 2023;32(2):141–7. https://doi.org/10.36036/MR.32.2.2023.140805

119 

Suleiman WB, Shehata RM, Younis AM. In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents. Bioresour Bioprocess. 2022;9(1):99. https://doi.org/10.1186/s40643-022-00592-6 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/38647811

120 

Bains A, Chawla P. In vitro bioactivity, antimicrobial and anti-inflammatory efficacy of modified solvent evaporation assisted Trametes versicolor extract. 3 Biotech. 2020;10(9):404. https://doi.org/10.1007/s13205-020-02397-w PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32903990

121 

Mousavi SM, Hashemi SA, Gholami A, Omidifar N, Chiang WH, Neralla VR, et al. Ganoderma lucidum methanolic extract as a potent phytoconstituent: Characterization, in-vitro antimicrobial and cytotoxic activity. Sci Rep. 2023;13(1):17326. https://doi.org/10.1038/s41598-023-44135-1 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37833299

122 

Cai WD, Ding ZC, Wang YY, Yang Y, Zhang HN, Yan JK. Hypoglycemic benefit and potential mechanism of a polysaccharide from Hericium erinaceus in streptozotoxin-induced diabetic rats. Process Biochem. 2020;88:180–8. https://doi.org/10.1016/j.procbio.2019.09.035

123 

Teng JF, Lee CH, Hsu TH, Lo HC. Potential activities and mechanisms of extracellular polysaccharopeptides from fermented Trametes versicolor on regulating glucose homeostasis in insulin-resistant HepG2 cells. PLoS One. 2018;13(7):e0201131. https://doi.org/10.1371/journal.pone.0201131 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/30024975

124 

Elsemelawy SA, Gharib MA, Elhassaneen YA. Reishi mushroom (Ganoderma lucidum) extract ameliorate hyperglycemia and liver/kidney functions in streptozotocin-induced type 2 diabetic rats. Bull Nat Nutr Inst Arab Rep Egypt. 2021;57(1):74–107. https://doi.org/10.21608/bnni.2021.221596

125 

Hiraki E, Furuta S, Kuwahara R, Takemoto N, Nagata T, Akasaka T, et al. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds. J Nat Med. 2017;71:482–91. https://doi.org/10.1007/s11418-017-1075-8 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/28181079

126 

Li X, Chen P, Zhang P, Chang Y, Cui M, Duan J. Protein‐bound β‐glucan from coriolus versicolor has potential for use against obesity. Mol Nutr Food Res. 2019;63(7):1801231. https://doi.org/10.1002/mnfr.201801231 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/30667154

127 

Lee HA, Cho JH, Afinanisa Q, An GH, Han JG, Kang HJ, et al. Ganoderma lucidum extract reduces insulin resistance by enhancing AMPK activation in high-fat diet-induced obese mice. Nutrients. 2020;12(11):3338. https://doi.org/10.3390/nu12113338 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33142995

128 

Hou XX, Liu JY, Li ZY, Chang MC, Guo M, Feng CP, et al. Fruiting body polysaccharides of Hericium erinaceus induce apoptosis in human colorectal cancer cells via ROS generation mediating caspase-9-dependent signaling pathways. Food Funct. 2020;11(7):6128–38. https://doi.org/10.1039/D0FO00916D PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32573644

129 

Lowenthal R, Taylor M, Gidden JA, Heflin B, Lay JO Jr, Avaritt N, et al. The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro. Biomed Pharmacother. 2023;161:114424. https://doi.org/10.1016/j.biopha.2023.114424 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36827712

130 

Roda E, Ratto D, De Luca F, Desiderio A, Ramieri M, Goppa L, et al. Searching for a longevity food, we bump into Hericium erinaceus primordium rich in ergothioneine: The “longevity vitamin” improves locomotor performances during aging. Nutrients. 2022;14(6):1177. https://doi.org/10.3390/nu14061177 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35334834

131 

D’Amico R, Trovato Salinaro A, Fusco R, Cordaro M, Impellizzeri D, Scuto M, et al. Hericium erinaceus and Coriolus versicolor modulate molecular and biochemical changes after traumatic brain injury. Antioxidants. 2021;10(6):898. https://doi.org/10.3390/antiox10060898 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34199629

132 

Gokce EC, Kahveci R, Atanur OM, Gürer B, Aksoy N, Gokce A, et al. Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats. Injury. 2015;46(11):2146–55. https://doi.org/10.1016/j.injury.2015.08.017 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/26298021

133 

Crawford LM, Kahlon TS, Wang SC, Friedman M. Acrylamide content of experimental flatbreads prepared from potato, quinoa, and wheat flours with added fruit and vegetable peels and mushroom powders. Foods. 2019;8(7):228. https://doi.org/10.3390/foods8070228 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31248030

134 

Hong Z, Xie J, Hu H, Bai Y, Hu X, Li T, et al. Hypoglycemic effect of Moringa oleifera leaf extract and its mechanism prediction based on network pharmacology. J Future Foods. 2023;3(4):383–91. https://doi.org/10.1016/j.jfutfo.2023.03.009

135 

Mumtaz MZ, Kausar F, Hassan M, Javaid S, Malik A. Anticancer activities of phenolic compounds from Moringa oleifera leaves: In vitro and in silico mechanistic study. Beni Suef Univ J Basic Appl Sci. 2021;10:12. https://doi.org/10.1186/s43088-021-00101-2

136 

Das PE, Majdalawieh AF, Abu-Yousef IA, Narasimhan S, Poltronieri P. Use of a hydroalcoholic extract of moringa oleifera leaves for the green synthesis of bismuth nanoparticles and evaluation of their anti-microbial and antioxidant activities. Materials (Basel). 2020;13(4):876. https://doi.org/10.3390/ma13040876 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32075305

137 

Khan MA, Shakoor S, Ameer K, Farooqi MA, Rohi M, Saeed M, et al. Effects of dehydrated moringa (Moringa oleifera) leaf powder supplementation on physicochemical, antioxidant, mineral, and sensory properties of whole wheat flour leavened bread. J Food Qual. 2023;2023:4473000. https://doi.org/10.1155/2023/4473000

138 

Waseem M, Akhtar S, Manzoor MF, Mirani AA, Ali Z, Ismail T, et al. Nutritional characterization and food value addition properties of dehydrated spinach powder. Food Sci Nutr. 2021;9(2):1213–21. https://doi.org/10.1002/fsn3.2110 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33598205

139 

Özcan MM. The effect of spice powders on bioactive compounds, antioxidant activity, phenolic components, fatty acids, mineral contents and sensory properties of “Keşkek”, which is a traditional food. Foods. 2022;11(21):3492. https://doi.org/10.3390/foods11213492 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36360106

140 

Negu A, Zegeye A, Astatkie T. Development and quality evaluation of wheat based cookies enriched with fenugreek and oat flours. J Food Sci Technol. 2020;57:3573–80. https://doi.org/10.1007/s13197-020-04389-3 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32903977

141 

Jaiswal A, Pathania V. An exploratory trial of food formulations with enhanced bioaccessibility of iron and zinc aided by spices. LWT – Food Sci Technol. 2021;143:111122. https://doi.org/10.1016/j.lwt.2021.111122

142 

Umaraw P, Chauhan G, Mendiratta SK, Verma AK, Arya A. Effect of oregano and bay as natural preservatives in meat bread for extension of storage stability at ambient temperature. J Food Process Preserv. 2020;44(4):e14375. https://doi.org/10.1111/jfpp.14375

143 

Zhao X, Ahn D, Nam G, Kwon J, Song S, Kang MJ, et al. Identification of crocetin as a dual agonist of GPR40 and GPR120 responsible for the antidiabetic effect of saffron. Nutrients. 2023;15(22):4774. https://doi.org/10.3390/nu15224774 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/38004168

144 

Zeka K, Marrazzo P, Micucci M, Ruparelia KC, Arroo RR, Macchiarelli G, et al. Activity of antioxidants from Crocus sativus L. petals: Potential preventive effects towards cardiovascular system. Antioxidants. 2020;9(11):1102. https://doi.org/10.3390/antiox9111102 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33182461

145 

Hatziagapiou K, Nikola O, Marka S, Koniari E, Kakouri E, Zografaki ME, et al. An in vitro study of saffron carotenoids: The effect of crocin extracts and dimethylcrocetin on cancer cell lines. Antioxidants. 2022;11(6):1074. https://doi.org/10.3390/antiox11061074 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35739971

146 

Khan A, Muhamad NA, Ismail H, Nasir A, Khalil AA, Anwar Y, et al. Potential nutraceutical benefits of in vivo grown saffron (Crocus sativus L.) as analgesic, anti-inflammatory, anticoagulant, and antidepressant in mice. Plants. 2020;9(11):1414. https://doi.org/10.3390/plants9111414 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33105854

147 

Gani A, Jan R, Ashwar BA. ul Ashraf Z, Shah A, Gani A. Encapsulation of saffron and sea buckthorn bioactives: Its utilization for development of low glycemic baked product for growing diabetic population of the world. LWT – Food Sci Technol. 2021;142:111035. https://doi.org/10.1016/j.lwt.2021.111035

148 

Kaur A, Kaur R, Bhise S. Baking and sensory quality of germinated and ungerminated flaxseed muffins prepared from wheat flour and wheat atta. J Saudi Soc Agric Sci. 2020;19(1):109–20. https://doi.org/10.1016/j.jssas.2018.07.002

149 

Kanikowska D, Malińska A, Mickiewicz A, Zawada A, Rutkowski R, Pawlaczyk K, et al. Effect of flaxseed (Linum usitatissimum L.) supplementation on vascular endothelial cell morphology and function in patients with dyslipidaemia - A preliminary observation. Nutrients. 2022;14(14):2879. https://doi.org/10.3390/nu14142879 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35889835

150 

Kuang X, Kong Y, Hu X, Li K, Guo X, Liu C, et al. Defatted flaxseed flour improves weight loss and lipid profile in overweight and obese adults: A randomized controlled trial. Food Funct. 2020;11(9):8237–47. https://doi.org/10.1039/D0FO00838A PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32966475

151 

Miranda-Ramos KC, Haros CM. Combined effect of chia, quinoa and amaranth incorporation on the physico-chemical, nutritional and functional quality of fresh bread. Foods. 2020;9(12):1859. https://doi.org/10.3390/foods9121859 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33322832

152 

Han K, Li XY, Zhang YQ, He YL, Hu R, Lu XL, et al. Chia seed oil prevents high fat diet induced hyperlipidemia and oxidative stress in mice. Eur J Lipid Sci Technol. 2020;122(4):1900443. https://doi.org/10.1002/ejlt.201900443

153 

Ma Y, Bao H, Wu X, Li X, Yan H, Dong W. Study on sensory properties and efficacy evaluation of whole wheat biscuits supplemented with peony seed oil and chia seed. Food Sci Technol. 2023;43:e001623. https://doi.org/10.1590/fst.001623

154 

Steffolani E, Martinez MM, León AE, Gómez M. Effect of pre-hydration of chia (Salvia hispanica L.), seeds and flour on the quality of wheat flour breads. LWT - Food Sci Technol. 2015;61(2):401–6. https://doi.org/10.1016/j.lwt.2014.12.056

155 

Dauda AO, Abiodun OA, Akintayo OA, Babayeju AA, Salami KO, Oyekanmi IA. Influence of walnut on the nutritional and physicochemical properties of biscuits made from whole wheat. Agrosearch. 2020;20(1):45–58. https://doi.org/10.4314/agrosh.v20i1.5S

156 

Nakakana H, Misbah SA, Hassan SM, Abdullahi H. Production and quality evaluation of enriched bread from flour blends of whole wheat, bambara nut, soybeans and cashew nut seed. FUDMA J Sci. 2023;7(5):34–8. https://doi.org/10.33003/fjs-2023-0705-1993

157 

Salve AR, Arya SS. Bioactive constituents, microstructural and nutritional quality characterisation of peanut flat bread. J Food Meas Charact. 2020;14(3):1582–94. https://doi.org/10.1007/s11694-020-00406-3

158 

Najjar Z, Alkaabi M, Alketbi K, Stathopoulos C, Ranasinghe M. Physical chemical and textural characteristics and sensory evaluation of cookies formulated with date seed powder. Foods. 2022;11(3):305. https://doi.org/10.3390/foods11030305 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35159461

159 

Upadhyay S, Tiwari R, Kumar S, Gupta SM, Kumar V, Rautela I, et al. Utilization of food waste for the development of composite bread. Sustainability. 2023;15(17):13079. https://doi.org/10.3390/su151713079

160 

Bouhlali ED, Derouich M, Hmidani A, Bourkhis B, Khouya T, Filali-Zegzouti Y, et al. Protective effect of Phoenix dactylifera L. seeds against paracetamol‐induced hepatotoxicity in rats: A comparison with vitamin C. ScientificWorldJournal. 2021;2021:6618273. https://doi.org/10.1155/2021/6618273 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34326710

161 

Dwitiyanti D, Rachmania RA, Efendi K, Septiani R, Jihadudin P. In vivo activities and in silico study of jackfruit seeds (Artocarpus heterophyllus lam.) on the reduction of blood sugar levels of gestational diabetes rate induced by streptozotocin. Open Access Maced J Med Sci. 2019;7(22):3819. https://doi.org/10.3889/oamjms.2019.512 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32127984

162 

Trejo Rodríguez IS, Alcantara Quintana LE, Algara Suarez P, Ruiz Cabrera MA, Grajales Lagunes A. Physicochemical properties, antioxidant capacity, prebiotic activity and anticancer potential in human cells of jackfruit (Artocarpus heterophyllus) seed flour. Molecules. 2021;26(16):4854. https://doi.org/10.3390/molecules26164854 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34443442

163 

Tramontin D, Cadena-Carrera SE, Assreuy J, Nunes R, Santin JR, Bolzan A, et al. Response surface methodology (RSM) to evaluate both the extraction of triterpenes and sterols from jackfruit seed with supercritical CO2 and the biological activity of the extracts. J Food Sci Technol. 2021;58:3303–13. https://doi.org/10.1007/s13197-020-04876-7 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/34366448

164 

Ngwere SS, Mongi RJ. Nutritional composition, sensory profile and consumer acceptability of wheat-jackfruit seed composite buns. Tanzan J Sci. 2021;47(3):1154–64. https://doi.org/10.4314/tjs.v47i3.24

165 

Tajaldini M, Samadi F, Khosravi A, Ghasemnejad A, Asadi J. Protective and anticancer effects of orange peel extract and naringin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse model. Biomed Pharmacother. 2020;121:109594. https://doi.org/10.1016/j.biopha.2019.109594 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31707344

166 

Huang YW, Liu Y, Dushenkov S, Ho CT, Huang MT. Anti-obesity effects of epigallocatechin-3-gallate, orange peel extract, black tea extract, caffeine and their combinations in a mouse model. J Funct Foods. 2009;1(3):304–10. https://doi.org/10.1016/j.jff.2009.06.002

167 

Oyawaluja AA, Oiseoghaede JO, Odukoya OA, Kubiat BE. Antioxidant and in-vitro antidiabetic activities of fermented peels of Citrus × sinensis (l.) Osbeck (Rutaceae). Progr Chem Biochem Res. 2021;4(4):414–25. https://doi.org/10.22034/pcbr.2021.305476.1199

168 

Olaoye OA, Ekeh JI, Okakpu CJ, Uka AC. Consumer acceptability and quality characteristics of cookies produced from composite flours of wheat and banana/avocado peels. Ann Food Sci Technol (Valahia Univ Târgoviste). 2019;20(1):56–64.

169 

De Marco ER, Steffolani ME, Martínez CS, León AE. Effects of spirulina biomass on the technological and nutritional quality of bread wheat pasta. LWT – Food Sci Technol. 2014;58(1):102–8. https://doi.org/10.1016/j.lwt.2014.02.054

170 

Hernández-López I, Alamprese C, Cappa C, Prieto-Santiago V, Abadias M, Aguiló-Aguayo I. Effect of Spirulina in bread formulated with wheat flours of different alveograph strength. Foods. 2023;12(20):3724. https://doi.org/10.3390/foods12203724 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37893617

171 

Oliveira BC, Machado M, Machado S, Costa AS, Bessada S, Alves RC, et al. Algae incorporation and nutritional improvement: The case of a whole-wheat pasta. Foods. 2023;12(16):3039. https://doi.org/10.3390/foods12163039 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37628038

172 

Gheda SF, Abo-Shady AM, Abdel-Karim OH, Ismail GA. Antioxidant and antihyperglycemic activity of Arthrospira platensis (Spirulina platensis) methanolic extract: In vitro and in vivo study. Egypt J Bot. 2021;61(1):71–93. https://doi.org/10.21608/ejbo.2020.27436.1482

173 

Grover P, Bhatnagar A, Kumari N, Bhatt AN, Nishad DK, Purkayastha J. C-Phycocyanin-a novel protein from Spirulina platensis - In vivo toxicity, antioxidant and immunomodulatory studies. Saudi J Biol Sci. 2021;28(3):1853–9. https://doi.org/10.1016/j.sjbs.2020.12.037 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33732072

174 

Al-Saman MA, Doleib NM, Ibrahim MR, Nasr MY, Tayel AA, Hamouda RA. In vitro and in vivo hypolipidemic properties of the aqueous extract of Spirulina platensis, cultivated in colored flasks under artificial illumination. PeerJ. 2020;8:e10366. https://doi.org/10.7717/peerj.10366 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33344072

175 

Prabakaran G, Sampathkumar P, Kavisri M, Moovendhan M. Extraction and characterization of phycocyanin from Spirulina platensis and evaluation of its anticancer, antidiabetic and antiinflammatory effect. Int J Biol Macromol. 2020;153:256–63. https://doi.org/10.1016/j.ijbiomac.2020.03.009 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32142842

176 

Rodriguez De Marco E, Steffolani ME, Martínez M, León AE. The use of Nannochloropsis sp. as a source of omega‐3 fatty acids in dry pasta: Chemical, technological and sensory evaluation. Int J Food Sci Technol. 2018;53(2):499–507. https://doi.org/10.1111/ijfs.13609

177 

Hossain AKMM, Brennan MA, Mason SL, Guo X, Zeng XA, Brennan CS. The effect of astaxanthin-rich microalgae “Haematococcus pluvialis” and wholemeal flours incorporation in improving the physical and functional properties of cookies. Foods. 2017;6(8):57. https://doi.org/10.3390/foods6080057 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/28933728

178 

Monteiro AB, Prados CR, Silva MD, Silva EP, Damiani C, Vendruscolo F. Production of Monascus pigments by solid-state cultivation of wheat grains and application in bread formulations. Int J Gastron Food Sci. 2021;24:100313. https://doi.org/10.1016/j.ijgfs.2021.100313

179 

Bhat NA, Wani IA, Hamdani AM. Tomato powder and crude lycopene as a source of natural antioxidants in whole wheat flour cookies. Heliyon. 2020;6(1):e03042. https://doi.org/10.1016/j.heliyon.2019.e03042 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31989047

180 

Oyeyinka SA, Adepegba AA, Oyetunde TT, Oyeyinka AT, Olaniran AF, Iranloye YM, et al. Chemical, antioxidant and sensory properties of pasta from fractionated whole wheat and bambara groundnut flour. LWT – Food Sci Technol. 2021;138:110618. https://doi.org/10.1016/j.lwt.2020.110618

181 

Namir M, Iskander A, Alyamani A, Sayed-Ahmed ET, Saad AM, Elsahy K, et al. Upgrading common wheat pasta by fiber-rich fraction of potato peel byproduct at different particle sizes: Effects on physicochemical, thermal, and sensory properties. Molecules. 2022;27(9):2868. https://doi.org/10.3390/molecules27092868 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35566217

182 

Bolaji OT, Adeyeye SA, Ogunmuyiwa D. Quality evalution of bread produced from whole wheat flour blended with watermelon seed flour. J Culin Sci Technol. 2022;22(4):607–30. https://doi.org/10.1080/15428052.2022.2068466

183 

Kefale B, Yetenayet B. Evaluation of bread prepared from composite flour of sweet lupine and bread wheat variety. J Food Sci Nutri The. 2020;6(1):7–10. https://doi.org/10.17352/jfsnt.000019

184 

Millicent OA. Quality characteristics and sensory evaluation of wheat bread partially substituted with cocoyam and bambara groundnuts flour. Nat Volatiles Essent Oils J. 2022;9(1):1934–43.

185 

Assis RQ, Andrade KL, Batista LE, de Oliveira Rios A, Dias DR, Ndiaye EA, et al. Characterization of mutamba (Guazuma ulmifolia LAM.) fruit flour and development of bread. Biocatal Agric Biotechnol. 2019;19:101120. https://doi.org/10.1016/j.bcab.2019.101120

186 

Lamont T, McSweeney M. Consumer acceptability and chemical composition of whole‐wheat breads incorporated with brown seaweed (Ascophyllum nodosum) or red seaweed (Chondrus crispus). J Sci Food Agric. 2021;101(4):1507–14. https://doi.org/10.1002/jsfa.10765 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32851673

187 

Tongbram T, Bora J, Senthil A, Kumar S. Formulation, development and evaluation of high fibre-high protein chapati (Indian flat bread) from composite flour using common industrial by-products. J Food Sci Technol. 2020;57:2739–49. https://doi.org/10.1007/s13197-020-04310-y PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32549624

188 

Kumar P, Kaur C, Jambh HK. Rheological, textural, and technological modifications in wheat unleavened flatbread substituted with extruded finger millet. J Texture Stud. 2021;52(3):400–9. https://doi.org/10.1111/jtxs.12595 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33754348

189 

Tandon N, Sachan S, Kumar V. Isolation, characterization of fenugreek gum and its effect on quality of chapatti (Indian unleavened flat bread). Mater Today Proc. 2021;43:2091–7. https://doi.org/10.1016/j.matpr.2020.11.886

190 

Agu HO, Ihionu JC, Mba JC. Sensory and physicochemical properties of biscuit produced from blends of whole wheat, soy okara and tigernut residue flours. Heliyon. 2023;9(4):e15318. https://doi.org/10.1016/j.heliyon.2023.e15318 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37123941

191 

Bello FA, Akpan ME, Sodipo MA. Physicochemical and sensory properties of cookies produced from wheat, unripe plantain and germinated fluted pumpkin seed composite flour. Food Sci Qual Manag. 2020;96:36–43. https://doi.org/10.7176/FSQM/96-05

192 

Baranwal D, Sankhla A. Physical and functional properties of malted composite flour for biscuit production. J Pharmacogn Phytochem. 2019;8(2):959–65.

193 

Nabil B, Ouaabou R, Ouhammou M, Essaadouni L, Mahrouz M. Functional properties, antioxidant activity, and organoleptic quality of novel biscuit produced by Moroccan cladode flour “Opuntia ficus-indica”. J Food Qual. 2020;2020:3542398. https://doi.org/10.1155/2020/3542398

194 

Kumari N, Sindhu SC, Kumari V, Rani V. Nutritional evaluation of developed value added biscuits incorporating germinated pumpkin seed flour. J Pharmacogn Phytochem. 2020;9(5):2802–6.

195 

Kulkarni AT, Agarkar BS, Sawate AR, Pawar PP. Determination of cooking quality of the composite flour noodles incorporated with chia seeds powder. J Pharmacogn Phytochem. 2020;9(5):76–8.

196 

Balmurugan M, Saravanakumar R, Kanchana S, Vellaikumar S, Mini ML, Haripriya S. Development of noodles using unripe banana flour and evaluation of its cooking characteristics and nutritional profile. Pharma Innov. 2022;5(7):954–9.

197 

Meherunnahar M, Ahmed T, Chowdhury RS, Miah MA, Sridhar K, Inbaraj BS, et al. Development of novel foxtail millet-based nutri-rich instant noodles: Chemical and quality characteristics. Foods. 2023;12(4):819. https://doi.org/10.3390/foods12040819 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/36832894

198 

Muthurajan M, Veeramani A, Rahul T, Gupta RK, Anukiruthika T, Moses JA, et al. Valorization of food industry waste streams using 3D food printing: A study on noodles prepared from potato peel waste. Food Bioprocess Technol. 2021;14(10):1817–34. https://doi.org/10.1007/s11947-021-02675-2

199 

Galanakis CM. Functionality of food components and emerging technologies. Foods. 2021;10(1):128. https://doi.org/10.3390/foods10010128 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33435589

200 

Melini V, Melini F, Acquistucci R. Phenolic compounds and bioaccessibility thereof in functional pasta. Antioxidants. 2020;9(4):343. https://doi.org/10.3390/antiox9040343 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32331474

201 

de Almeida SS, da Costa GB, Barreto MS, Freire DM, Lobo LA, Domingues RM, et al. Bioaccessibility and gut metabolism of phenolic compounds of breads added with green coffee infusion and enzymatically bioprocessed. Food Chem. 2020;333:127473. https://doi.org/10.1016/j.foodchem.2020.127473 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32659670

202 

Marak NR, Das P, Das Purkayastha M, Baruah LD. Effect of quinoa (Chenopodium quinoa W.) flour supplementation in breads on the lipid profile and glycemic index: An in vivo study. Front Nutr. 2024;11:1341539. https://doi.org/10.3389/fnut.2024.1341539 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/38595791

203 

Olagunju AI, Oluwajuyitan TD, Oyeleye SI. Multigrain bread: Dough rheology, quality characteristics, in vitro antioxidant and antidiabetic properties. J Food Meas Charact. 2021;15:1851–64. https://doi.org/10.1007/s11694-020-00670-3

204 

Bhavya SN, Prakash J. Nutritional properties of iron fortified flatbreads enriched with greens and legumes. J Food Process Preserv. 2021;45(5):e15495. https://doi.org/10.1111/jfpp.15495

205 

Gomathi GK, Parameshwari S. Evaluation of buckwheat flour addition on the sensory, nutritional and materialistic properties analysis of Indian flat bread. Mater Today Proc. 2022;66(3):988–95. https://doi.org/10.1016/j.matpr.2022.04.778

206 

Sachanarula S, Chantarasinlapin P, Adisakwattana S. Substituting whole wheat flour with pigeon pea (Cajanus cajan) flour in chapati: Effect on nutritional characteristics, color profiles, and in vitro starch and protein digestion. Foods. 2022;11(20):3157. https://doi.org/10.3390/foods11203157 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37430905

207 

Sakhare SD, Prabhasankar P. Effect of fenugreek fiber on rheological and chapati making quality of whole wheat flour. J Food Sci Technol. 2022;59(2):532–41. https://doi.org/10.1007/s13197-021-05037-0 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/35185174

208 

Büyük Z, Dulger Altiner D. Investigation of antioxidant and sensory properties and in vitro bioaccessibility of low‐fat functional cookies substituted with wheat germ flour and coffee silverskin. J Sci Food Agric. 2024;104(3):1322–34. https://doi.org/10.1002/jsfa.13013 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37770412

209 

Manzoor S, Rakha A, Rasheed H, Munir S, Abdi G, Bhat ZF, et al. Development and evaluation of anxiolytic potential of bagels incorporated with banana peel flour and lavender. J Agric Food Res. 2024;15:101029. https://doi.org/10.1016/j.jafr.2024.101029


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