ADMET and DMPK, Vol. 13 No. 6, 2025.
Izvorni znanstveni članak
https://doi.org/10.5599/admet.3010
ZnO-modified carbon paste electrode for electrochemical sensing of dopamine in the presence of tyrosine
Ali Obaid Imarah
orcid.org/0000-0003-0450-2588
; Department of Chemical Engineering, College of Engineering, University of Babylon, Babylon Iraq
*
Nada Hasan
; Department of Basic Science, College of Dentistry, Al-Mustaqbal University, Babylon, Hillah, 51001, Iraq
Mustafa G. Alabbasi
; Department of Pharmacology and Toxicology, College of Pharmacy, University of Alkafeel, Iraq
* Dopisni autor.
Sažetak
Background and purpose: Dopamine, 3,4-dihydroxyphenylalanine, functions as a catecholamine neurotransmitter in the brain, sending messages to other neurons to regulate information transmission to other areas of the brain, govern movement, and alter brain activity. Tyrosine undergoes an enzymatic process in the pharmaceutical industry to produce dopamine. Thus, it is crucial to measure both tyrosine and dopamine in bodily fluids simultaneously. Experimental approach: In this work, we demonstrate the production of ZnO nanoparticles using a straightforward solvothermal technique. A straightforward, quick, and sensitive electrochemical sensing platform for dopamine detection was then created using the produced ZnO nanoparticles. Key results: Cyclic voltammetry comparison revealed that the ZnO/carbon paste electrode considerably enhanced the dopamine oxidation process compared to the unmodified carbon paste electrode (CPE). With a low detection limit of 0.003 μM, the ZnO/CPE sensor's linear response for voltammetric dopamine determination was found to be between 0.01 and 480.0 μM. Conclusion: The modified CPE effectively demonstrates its great accuracy in tyrosine-induced dopamine detection.
Ključne riječi
ZnO nanoparticles; voltammetry; Alzheimer's disease; Parkinson's disease; chronoamperometry
Hrčak ID:
342108
URI
Datum izdavanja:
21.10.2025.
Posjeta: 332 *